IP Library › Granted Patent US 8,821,866
Granted Patent B2
US 8,821,866 · App. 13/464,323 · Granted Sep 2, 2014

Methods of treating and preventing colitis involving IL-13 and NK-T cells

Inventors: Warren Strober (Bethesda, MD); Ivan J. Fuss (Bethesda, MD); Frank Heller (Bethesda, MD); Richard S. Blumberg (Chestnut Hill, MA)
Assignee: The United States of America, as represented by the Secretary, Department of Health & Human Services
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 8,821,866
App. No.
13/464,323
Granted
Sep 2, 2014
Kind
B2
Abstract

Method of treating or preventing the inflammatory response of colitis in a subject comprising administering to the subject an effective amount of a substance that modulates IL-13 activity (FIG. 3 ). The invention also provides a method of treating or preventing the inflammatory response of colitis in a subject comprising administering to the subject an effective amount of a substance that modulates NK-T cell activity. The invention also provides for the screening of substances that treat or prevent the inflammatory response of colitis.

Claims (3)

1. A method of treating or preventing the inflammatory response of ulcerative colitis in a subject comprising administering to the subject an effective amount of an antibody, or antigen-binding fragment thereof, that binds to IL-13Rα2 and reduces IL-13 activity.

2. The method of claim 1 , wherein the subject is a human.

3. The method of claim 1 , wherein the colitis is caused by an inflammatory bowel disorder.

Assignments (2)
CONFIRMATORY LICENSE Recorded Apr 22, 2024
From: BRIGHAM AND WOMEN'S HOSPITAL
To: NATIONAL INSTITUTES OF HEALTH
Reel/Frame 067179/0695 →
CONFIRMATORY LICENSE Recorded Mar 20, 2023
From: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
To: NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR
Reel/Frame 063035/0511 →
Continuity (3)
Division 12709029 · Feb 19, 2010
Division 10517898
Related Publication 20120276113A1 · Nov 1, 2012