Derivatives of (bridged piperazinyl)-1-alkanone and use thereof as p75 inhibitors
The present invention relates to derivatives of ((phenyl)-3,6-dihydropyridin-1-yl)(bridged piperazinyl)-1-alkanone derivatives and ((phenyl)-2,5-dihydropyrrol-1-yl) (bridged piperazinyl)-1-alkanone corresponding to Formula (I): in which the variables are as defined herein, to the preparation thereof and to the therapeutic use thereof.
1. A compound of Formula (II):
in which:
m represents 0 or 1;
A represents:
and B represents a hydrogen atom or
A represents a hydrogen atom and B represents:
n represents 1 or 2;
R1 represents a halogen atom, a (C 1 -C 4 )alkyl group, a trifluoromethyl group, a (C 1 -C 4 )alkoxy group or a trifluoromethoxy group;
R2 represents a hydrogen atom, a halogen atom, a (C 1 -C 4 )alkyl group, a trifluoromethyl group, a (C 1 -C 4 )alkoxy group, a trifluoromethoxy group, a COOR group or a CONH 2 group;
R represents a C 1 -C 6 alkyl group;
and Hal represents a halogen atom;
with the exception of 2-chloro-1-[4-(2-methoxyphenyl)-3,6-dihydro-2H-pyridin-1 -yl]ethanone and of 2-chloro-1-[4-(4-bromophenyl)-3,6-dihydro-2H-pyridin-1 -yl]ethanone;
in the form of a base or of a pharmaceutically acceptable addition salt with an acid.
2. A compound according to claim 1 , in which R2 is a hydrogen atom, a trifluoromethyl group, a COOR group or a CONH 2 group; in the form of a base or of a pharmaceutically acceptable addition salt with an acid.
3. A compound according to claim 1 , wherein:
m represents 1;
A represents:
and B represents a hydrogen atom;
n represents 1 or 2;
R1 represents a halogen atom, a (C 1 -C 4 )alkyl group, a trifluoromethyl radical, a (C 1 -C 4 )alkoxy group or a trifluoromethoxy radical; and
R2 represents a hydrogen atom, a halogen atom, a (C 1 -C 4 )alkyl group, a trifluoromethyl radical, a (C 1 -C 4 )alkoxy group or a trifluoromethoxy radical;
in the form of a base or of a pharmaceutically acceptable addition salt with an acid.
4. A compound according to claim 1 , wherein n=1;in the form of a base or of a pharmaceutically acceptable addition salt with an acid.
5. A compound according to claim 1 , wherein R1 is a halogen atom or a trifluoromethyl radical; in the form of a base or of a pharmaceutically acceptable addition salt with an acid.
6. A compound according to claim 1 , wherein R2 is a hydrogen atom or a trifluoromethyl radical; in the form of a base or of a pharmaceutically acceptable addition salt with an acid.