Methods of use for IL-22 promoting rejuvenation of thymic and bone marrow function
The present invention provides methods and compositions for the use of IL-22 to promote thymic growth following thymic insult. In particularly preferred embodiments, the present invention provides methods of using therapeutic IL-22 compositions for treating patients with thymic atrophy and alterations in bone marrow derived white blood cells, including cancer patients undergoing chemotherapy, patients exposed to radiation (i.e. cancer therapy, nuclear disaster, terrorist attack, etc.), patients with HIV infections/AIDS, patients with organ transplantation, aging patients, and the like. In a further embodiment, therapeutic IL-22 compositions are contemplated as a prophylactic to boost immune response when additional T-cell function is needed, i.e. to boost immune response during vaccination.
1. A method of treatment for increasing thymic epithelial cell (TEC) function, comprising:
a) contacting thymic epithelial cells at least a portion of which have reduced function with IL-22 wherein IL-22 improves the function of said portion of thymic epithelial cells having reduced function.
2. The method of claim 1 , wherein said IL-22 is human IL-22.
3. The method of claim 1 , wherein said function of said thymic epithelial cells is ability to promote development of mature thymocytes.
4. The method of claim 1 , wherein said reduced function of thymic epithelial cells is characterized by a lower number of mature functional thymocytes.
5. The method of claim 1 , wherein said increased function of thymic epithelial cells is ability to promote development of mature thymocytes.
6. The method of claim 1 , wherein said increased function of said thymic epithelial cells is characterized by an increased number of mature functional thymocytes.
7. The method of claim 1 , further comprising administering IL-23.
8. The method of claim 1 , wherein said reduced function of thymic epithelial cells is characterized by a lower number of mature functional T-cells.
9. The method of claim 1 , wherein contacting said thymic epithelial cells with IL-22 is in vivo.
10. The method of claim 1 , wherein contacting said thymic epithelial cells with IL-22 is in vitro.