TREATMENT OF MIGRAINE HEADACHE WITH DIFFUSION OF TOXIN IN NON-MUSCLE RELATED AREAS OF THE MOUTH
A method for treating a patient with migraine headache includes administering to the patient a therapeutically effective amount of an invertebrate presynaptic neurotoxin in a pharmaceutically safe form. The administration includes intra-oral extramuscular injection of the neurotoxin in a foramina of the sphenopalatine ganglion for enabling diffusion of the neurotoxin to the ganglion with the administration being on the trigeminal cervical system, enabling axonal transport of the neurotoxin from distal to central sites.
1 . A method for treating a human patient with migraine headache, said method comprising:
administering to the patient a therapeutically effective amount of a diluted Botulinum toxin in a pharmaceutically safe form;
the administration comprising intra-oral extramuscular injection of the Botulinum toxin in a foramina of the sphenopalatine ganglion without deep needle administration,
for enabling diffusion of the Botulinum toxin to the ganglion; and
the administration being on the trigeminal cervical system, enabling axonal transport of the Botulinum toxin from distal to central sites.
2 . (canceled)
3 . The method according to claim 1 wherein the Botulinum toxin is Botulinum Toxin A.
4 . The method according to claim 1 wherein the diluted Botulinum toxin is about 1 cc normal saline per 100 units of Botulinum toxin.
5 . The method according to claim 1 wherein the Botulinum toxin comprises an Endotoxin obtained from Botulinum toxin.
6 . The method of claim 5 wherein the Endotoxin is an endopeptidase obtained from Botulinum toxin.
7 . The method of claim 1 , wherein administering comprises injecting Botulinum toxin into one or more of the greater palatine foramen, the lesser palatine foramen and the incisive foramen.
8 . The method according to claim 1 wherein the Botulinum toxin is Botulinum Toxin B.
9 . The method of claim 3 wherein the Botulium toxin A is onabotulinumtoxin A.
10 . A method for treating a human patient with migraine headache, said method comprising administering to the patient a therapeutically effective amount of diluted Botulinum toxin in a pharmaceutically safe form; the administration comprising intra-oral extramuscular injection into one or more of the greater palatine foramen, the lesser palatine foramen and the incisive foramen.
11 . The method according to claim 10 wherein the dilution of the Botulinum toxin is about 1 cc normal saline per 100 units of Botulinum toxin.
12 . The method according to claim 11 wherein the Botulinum toxin is Botulinum toxin A.
13 . The method according to claim 12 wherein the Botulinum toxin A is onabotulinumtoxin A.
14 . A method for treating a human with migraine headache comprising administering a therapeutically effective amount of onabotulinumtoxin A, at a dilution of about 1 cc normal saline per 100 units of onabotulinumtoxin A, by extramuscular injection into one or more of the greater palatine foramen, the lesser palatine foramen and the incisive foramen.
15 . The method of claim 1 wherein administration comprises intraoral extramuscular injection to either the region of the mucobuccal fold at the maxillary second molar or through the greater palatine canal located between the second and third molars approximately 7 mm from the end of the hard palate.