Pharmaceutical compositions comprising DGLA and benzoyl peroxide and methods of use thereof
The present disclosure provides compositions comprising fatty acids, or derivatives thereof (e.g., C1-C4 esters) including, for example, DGLA, 15-OHEPA and/or 15-HETrE, used singly or in combination with anti-bacterial agents for the treatment of disease and/or disorders such as acne or atopic dermatitis.
1. A topically deliverable pharmaceutical composition comprising a therapeutically effective amount of dihomo-gamma-linolenic acid and benzoyl peroxide.
2. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition comprises about 1.25 wt. % to about 10 wt. % of benzoyl peroxide.
3. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition comprises about 0.1 wt. % to about 20 wt. % of dihomo-gamma-linolenic acid.
4. The pharmaceutical composition of claim 1 , wherein the composition is a cream.
5. A method of treating or inhibiting development of acne in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of the pharmaceutical composition of claim 1 .
6. The method of claim 5 , wherein the step of administering comprises applying the pharmaceutical composition to an area of skin of the subject afflicted with acne lesions.
7. The method of claim 5 , wherein the acne is associated with Propionibacterium acnes.
8. The method of claim 5 , wherein the pharmaceutical composition is administered to the subject once a day, twice a day, or three times a day.
9. The method of claim 5 , wherein the pharmaceutical composition is a cream.
10. The method of claim 5 , wherein the pharmaceutical composition comprises about 0.1 wt. % to about 20 wt. % of dihomo-gamma-linolenic acid.
11. The method of claim 5 , wherein the pharmaceutical composition comprises about 1.25 wt. % to about 10 wt. % of benzoyl peroxide.