IP Library › Patent Application 13478990
Patent Application
App. No. 13/478,990

ANTIMICROBIAL COMPOSITIONS COMPRISING 15-HETRE AND METHODS OF USE THEREOF

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Patent No.
US None
App. No.
13/478,990
Abstract

The present disclosure provides compositions comprising fatty acids, or derivatives thereof (e.g., C1-C4 esters) including, for example, DGLA, 15-OHEPA and/or 15-HETrE, used alone or in combination with one or more antibiotic agents for the treatment of disease and/or disorders such as a skin infection or wound healing.

Claims (17)

1 . An antimicrobial composition comprising a therapeutically effective amount of 15-HETrE.

2 . The antimicrobial composition of claim 1 , wherein the composition comprises about 0.1 wt. % to about 20 wt. % of 15-HETrE.

3 . The antimicrobial composition of claim 2 , wherein the 15-HETrE is in free acid form.

4 . The antimicrobial composition of claim 1 , wherein the 15-HETrE is a pharmaceutically acceptable ester, derivative, conjugate, or salt of 15-HETrE.

5 . The antimicrobial composition of claim 4 , wherein the 15-HETrE is a alkyl ester of 15-HETrE.

6 . The antimicrobial composition of claim 1 , wherein the composition further comprises an additional active agent selected from neomycin sulfate, polymyxin B, bacitracin zinc, and combinations thereof.

7 . The antimicrobial composition of claim 6 , wherein the additional active agent is present in an amount that is less than a generally recognized therapeutic amount for said additional active agent.

8 . The antimicrobial composition of claim 1 , wherein the composition is suitable for topical delivery.

9 . The antimicrobial composition of claim 1 , wherein the 15-HETrE has been deodorized.

10 . The antimicrobial composition of claim 1 , wherein the composition inhibits growth of P. aeroginosa, E. coli, K. pneumoniae, S. aureus, E. faecalis, S. epidermidis, C. striatum, A. brasiliensis, C. albicans , or any combination thereof.

11 . The composition of claim 1 wherein the composition is an antibacterial composition.

12 . The composition of claim 1 wherein the composition is an antifungal composition.

13 . A method of treating or preventing a microbial infection comprising administering to a subject in need thereof an antimicrobial composition according to claim 1 .

14 . The method of claim 13 , wherein the antimicrobial composition is topically applied to a wound of the subject.

15 . The method of claim 13 wherein the microbial infection is a bacterial infection.

16 . The method of claim 13 wherein the microbial infection is a fungal infection.

17 . A method of minimizing or preventing scarring comprising administering to a wound of a subject the antibacterial composition of claim 1 .

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 22, 2012
From: MANKU, MEHAR; CLIMAX, JOHN; ROWE, JONATHAN; COUGHLAN, DAVID
To: DIGNITY SCIENCES LIMITED
Reel/Frame 028429/0061 →