Color changing polymer films for detecting chemical and biological targets
A sensor system, and a method of detecting a target analyte, comprises a chemically functionalized block copolymer, and a target analyte. The block copolymer exhibits a color change in the visible spectrum upon exposure to the target analyte.
1. A sensor system, comprising:
(A) a chemically functionalized block copolymer having a lamellar morphology including at least two layers
(B) an antibody linked to said functionalized block copolymer; and
(C) a target analyte;
wherein said antibody binds a moiety of said target analyte, thereby inducing a change in distance between said layers so that said block copolymer exhibits a color change in the visible spectrum upon exposure to and selective recognition of said target analyte.
2. The sensor system of claim 1 , wherein said functionalized block copolymer is a polystyrene-b-poly(2-vinyl pyridine) (PS-b-P2VP) block copolymer.
3. The sensor system of claim 2 , wherein the P2VP block of said copolymer is functionalized with 2-bromomethylphenylboronic acid or bromoethylamine.
4. The sensor system of claim 1 , wherein said target analyte is selected from the group consisting of glucose, fructose, galactose and mannose.
5. The sensor system of claim 1 , wherein said target analyte is selected from the group consisting of a foodborne pathogen, a toxin, and an explosive compound.
6. The sensor system of claim 5 , wherein said foodborne pathogen is selected from the group consisting of Escherichia coli, Listeria , and Salmonella.
7. The sensor system of claim 5 , wherein said toxin is selected from the group consisting of ricin, sarin, and soman.
8. The sensor system of claim 5 , wherein said explosive compound is selected from the group consisting of nitroglycerin and triacetone triperoxide.
9. The sensor system of claim 1 , wherein said antibody is polyclonal ovalbumin antibody.
10. The sensor system of claim 1 , wherein said functionalized block copolymer is coupled to a textile material.
11. A sensor system, comprising:
(I) A chemically functionalized block copolymer having a lamellar morphology including at least two layers; and
(II) an antibody linked to said functionalized block copolymer, wherein said antibody is capable of binding a moiety of a target analyte,
wherein the distance between said layers changes upon exposure to and selective recognition of said target analyte by said antibody so that said functionalized block copolymer exhibits a shift in peak wavelength in the visible spectrum.
12. The sensor system of claim 11 , wherein said functionalized block copolymer is a polystyrene-b-poly(2-vinyl pyridine) (PS-b-P2VP) block copolymer.
13. The sensor system of claim 12 , wherein the P2VP block of said copolymer is functionalized with 2-bromomethylphenylboronic acid or bromoethylamine.
14. The sensor system of claim 11 , wherein said target analyte is selected from the group consisting of glucose, fructose, galactose and mannose.
15. The sensor system of claim 11 , wherein said target analyte is selected from the group consisting of a foodborne pathogen, a toxin, and an explosive compound.
16. The sensor system of claim 15 , wherein said foodborne pathogen is selected from the group consisting of Escherichia coli, Listeria , and Salmonella.
17. The sensor system of claim 15 , wherein said toxin is selected from the group consisting of ricin, sarin, and soman.
18. The sensor system of claim 15 , wherein said explosive compound is selected from the group consisting of nitroglycerin and triacetone triperoxide.
19. The sensor system of claim 11 , wherein said antibody is polyclonal ovalbumin antibody.
20. The sensor system of claim 11 , wherein said functionalized block copolymer is coupled to a textile material.