IP Library › Granted Patent US 8,653,233
Granted Patent B2
US 8,653,233 · App. 13/486,434 · Granted Feb 18, 2014

Compositions and methods for preventing or treating cancer

Inventors: Michael Anthony Hollingsworth (Omaha, NE); Karl Kohlgraf (Iowa City, IA); Tom Caffrey (Bellevue, NE)
Assignee: University of Nebraska Medical Center
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Quick Facts
Patent No.
US 8,653,233
App. No.
13/486,434
Granted
Feb 18, 2014
Kind
B2
Abstract

The present invention relates to a MUC1 cytoplasmic tail peptide or portion thereof. These peptides are useful for inducing an immune response to MUC1-expressing tumor cells and thus for preventing or treating cancer.

Claims (6)

1. A composition comprising a MUC1 cytoplasmic tail peptide, wherein said MUC1 cytoplasmic tail peptide consists of a 9 to 15 amino acid portion of SEQ ID NO: 48, and wherein said MUC1 cytoplasmic tail peptide comprises a sequence selected from the group consisting of SEQ ID NO: 22, SEQ ID NO: 24, SEQ ID NO: 42, SEQ ID NO: 45, and SEQ ID NO: 46.

2. The composition of claim 1 , further comprising at least one additional MUC1 cytoplasmic tail peptide consisting of a 9 to 15 amino acid portion of SEQ ID NO: 1.

3. The composition of claim 2 , wherein said additional MUC1 cytoplasmic tail peptide consists of a 9 to 15 amino acid portion of SEQ ID NO: 47.

4. The composition of claim 2 , wherein said additional MUC1 cytoplasmic tail peptide consists of a 9 to 15 amino acid portion of SEQ ID NO: 49.

5. The composition of claim 1 , wherein said composition comprises more than one of said MUC1 cytoplasmic tail peptides.

6. The composition of claim 1 further comprising a carrier protein.

Assignments (1)
CONFIRMATORY LICENSE Recorded Jun 18, 2012
From: UNIVERSITY OF NEBRASKA MEDICAL CENTER
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 028389/0887 →
Continuity (3)
Division 12696603 · Jan 29, 2010
Division 10618481 · Jul 11, 2003
Related Publication 20120270798A1 · Oct 25, 2012