IP Library › Granted Patent US 8,461,140
Granted Patent B2
US 8,461,140 · App. 13/486,955 · Granted Jun 11, 2013

Synthetic bile acid compositions and methods

Inventors: Robert M. Moriarty (Michiana City, IN); Nathaniel E. David (Los Angeles, CA); Nadir Ahmeduddin Mahmood (Calabasas, CA)
Assignee: Kythera Biopharmaceuticals, Inc.
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Quick Facts
Patent No.
US 8,461,140
App. No.
13/486,955
Granted
Jun 11, 2013
Kind
B2
Abstract

Bile acids and related compositions and methods of synthesis and use. More specifically, deoxycholic acid and related compositions, said compositions being free of all moieties of animal origin and free of pyrogenic moieties.

Claims (6)

1. An aqueous pharmaceutical formulation comprising about 0.1% w/v to about 2% w/v deoxycholate and at least one pharmaceutically acceptable excipient and/or carrier, wherein the deoxycholate has a 14 C content of less than 1 ppt.

2. The formulation of claim 1 , wherein the deoxycholate has a 14 C content of less than 0.9 ppt.

3. The pharmaceutical formulation of claim 1 , which is suitable for subcutaneous injection.

4. The pharmaceutical formulation of claim 1 , wherein the deoxycholate has a 14 C content of 0.87 ppt.

5. The pharmaceutical formulation of claim 1 , wherein the deoxycholate has a 14 C content of 0.88 ppt.

6. The pharmaceutical formulation of claim 1 , wherein the deoxycholate has a 14 C content of 0.89 ppt.

Assignments (3)
MERGER AND CHANGE OF NAME Recorded Oct 10, 2019
From: KYTHERA BIOPHARMACEUTICALS, LLC; ALLERGAN SALES, LLC
To: ALLERGAN SALES, LLC
Reel/Frame 050683/0718 →
CHANGE OF NAME Recorded Oct 7, 2019
From: KYTHERA BIOPHARMACEUTICALS, INC.
To: KYTHERA BIOPHARMACEUTICALS, LLC
Reel/Frame 050648/0981 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 14, 2012
From: MORIARTY, ROBERT M.; DAVID, NATHANIEL E.; MAHMOOD, NADIR AHMEDUDDIN
To: KYTHERA BIOPHARMACEUTICALS, INC.
Reel/Frame 028969/0350 →
Continuity (5)
Continuation 12541045 · Aug 13, 2009
Continuation In Part 12035339 · Feb 21, 2008
Provisional Application 60945035 · Jun 19, 2007
Provisional Application 60956875 · Aug 20, 2007
Related Publication 20120238537A1 · Sep 20, 2012