IP Library › Granted Patent US 10,640,457
Granted Patent B2
US 10,640,457 · App. 13/493,490 · Granted May 5, 2020

Histone acetyltransferase activators and uses thereof

Inventors: Yan Feng (Shanghai, CN); Mauro Fa (New York, NY); Ottavio Arancio (New York, NY); Shixian Deng (White Plains, NY); Donald W. Landry (New York, NY); Yitshak Francis (New York, NY)
Assignee: The Trustees of Columbia University in the City of New York
C07C235/64C07C235/56C07C237/40C07C323/42C07C323/44C07C323/60C07C323/67C07D213/75C07D213/82C07D239/52C07D333/38C12Q1/48C07C2601/08G01N2500/04G01N2800/2814
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Quick Facts
Patent No.
US 10,640,457
App. No.
13/493,490
Granted
May 5, 2020
Kind
B2
Abstract

The invention provides for a method for screening compounds that bind to and modulate a histone acetyltransferase protein. The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a HAT-activating compound to a subject.

Claims (5)

1. A compound having the following structure

or a pharmaceutically acceptable salt or hydrate thereof.

2. The compound of claim 1 , wherein the compound is a pharmaceutically acceptable salt.

3. The compound of claim 2 , wherein the pharmaceutically acceptable salt is an acid addition salt.

4. The compound of claim 3 , wherein the compound is a hydrochloride salt.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 28, 2012
From: FRANCIS, YITSHAK; ARANCIO, OTTAVIO; LANDRY, DONALD; FA, MAURO; FENG, YAN; DENG, SHIXIAN
To: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
Reel/Frame 029543/0244 →
CONFIRMATORY LICENSE Recorded Jul 24, 2012
From: COLUMBIA UNIV NEW YORK MORNINGSIDE
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 028623/0559 →
Continuity (8)
Continuation In Part PCTUS2010059925 · Dec 10, 2010
Provisional Application 61285287 · Dec 10, 2009
Provisional Application 61317765 · Mar 26, 2010
Provisional Application 61354964 · Jun 15, 2010
Provisional Application 61355110 · Jun 15, 2010
Provisional Application 61363009 · Jul 9, 2010
Provisional Application 61539697 · Sep 27, 2011
Related Publication 20130121919A1 · May 16, 2013