Nanocarriers with multi-photon response elements
Compositions are provided in which dendrimers and/or nanoparticles are synthesized with multi-photon responsive elements and self-immolative oligomers. The compositions may be utilized to selectively deliver Payloads within tissue by irradiating the compositions. The compositions may also be used to amplify sensitivity to irradiation.
1. A molecular network for encapsulating a Payload, the molecular network comprising:
polymer strands; and
a crosslinker adapted to crosslink the polymer strands to define a carrier that encapsulates the Payload, the crosslinker comprising a multi-photon responsive element covalently linked to a self-immolative backbone subunit, wherein the crosslinker cleaves to unravel the polymer strands and release the Payload when exposed to a multi-photon trigger, wherein said self-immolative backbone subunit is an oligomer comprising the structure
or derivatives thereof, where “PG” denotes a protecting group.
2. The molecular network of claim 1 wherein said multi-photon responsive element is a two-photon responsive element.
3. The molecular network of claim 2 wherein said multi-photon responsive unit is a bromo-coumarin group.
4. The molecular network of claim 1 wherein the polymer strands comprise polyacrylamide polymers or PEG polymers.
5. The molecular network of claim 4 wherein the Payload comprises a pharmaceutical agent, stem cell differentiation agents, immunogen or antibodies.
6. A nanocarrier for delivery of a Payload, the nanocarrier comprising:
a molecular cage adapted for encapsulating the Payload, wherein the molecular cage comprises polymer strands crosslinked by a multi-photon responsive element covalently linked to a self-immolative backbone subunit, and wherein the molecular cage is adapted to unravel and release the Payload upon exposure to a multi-photon trigger, wherein said self-immolative backbone subunit is an oligomer comprising the structure
or derivatives thereof, where “PG” denotes a protecting group.
7. The nanocarrier of claim 6 wherein said multi-photon responsive element is a two-photon responsive element.
8. The composition nanocarrier of claim 6 wherein said multi-photon responsive unit is a bromo-coumarin group.
9. The nanocarrier of claim 6 wherein the polymer strands comprise polyacrylamide polymers or PEG polymers.
10. The nanocarrier of claim 6 wherein the Payload comprises a pharmaceutical agent, stem cell differentiation agents, immunogen or antibodies.
11. The nanocarrier of claim 6 , wherein the multi-photon trigger comprises near infrared light or ultraviolet light.
12. A molecular network comprising:
strands of polyacrylamide or PEG crosslinked by a crosslinker to form a carrier that mechanically encapsulates a Payload, the crosslinker comprising a dual-photon responsive element covalently linked to a self-immolative backbone subunit, wherein, upon exposure to a dual-photon trigger, the crosslinker cleaves to unravel the strands and release the Payload, wherein said self-immolative backbone subunit is an oligomer comprising the structure
or derivatives thereof, where “PG” denotes a protecting group.
13. The molecular network of claim 12 wherein the dual-photon responsive unit is a bromo-coumarin group.
14. The molecular network of claim 12 wherein the Payload comprises a pharmaceutical agent, stem cell differentiation agents, immunogen or antibodies.
15. The molecular network of claim 12 , wherein the dual-photon trigger comprises near infrared light or ultraviolet light.
16. The molecular network of claim 12 , wherein the cross-linker comprises:
17. The molecular network of claim 1 , wherein the cross-linker comprises:
18. The molecular network of claim 12 , wherein the cross-linker comprises:
where “T” denotes the dual-photon responsive element.
19. The molecular network of claim 1 , wherein the cross-linker comprises:
where “T” denotes the multi-photon responsive element.