Methods for preventing oxidative stress injury of a tissue by a Folate-TEMPOL conjugate
The present disclosure is generally related to methods of preventing oxidative stress injury induced by renal ischemia-reperfusion by a Folate-TEMPOL conjugate.
1. A pharmaceutical composition comprising a conjugate having the formula:
or an ester of the carboxylic acid or pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.
2. A biological storage solution comprising a conjugate having the formula:
or an ester of the carboxylic acid or salt thereof, wherein the solution further comprising a component selected from a salt, amino acid, vitamin, a saccharide, a polysaccharide, and adenosine triphosphate or precursor.
3. A method of treating ischemic injury comprising administering a pharmaceutical composition of claim 1 to a subject.
4. The method of claim 3 , wherein the subject is diagnosed with reduced kidney function.
5. The method of claim 3 , wherein the subject received an organ transplant.
6. The method of claim 3 , wherein the pharmaceutical composition is delivered to the subject before, after, or during a medical procedure.