IP Library › Granted Patent US 8,604,208
Granted Patent B2
US 8,604,208 · App. 13/497,861 · Granted Dec 10, 2013

Polymorphs of sorafenib acid addition salts

Inventors: Jagdev Singh Jaryal (Kangra, IN); Swargam Sathyanarayana (Karim Nagar, IN); Rajesh Kumar Thaper (Jammu, IN); Mohan Prasad (Gurgaon, IN)
Assignee: Ranbaxy Laboratories Limited
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Quick Facts
Patent No.
US 8,604,208
App. No.
13/497,861
Granted
Dec 10, 2013
Kind
B2
Abstract

The present invention provides amorphous and crystalline forms of acid addition salts of sorafenib, pharmaceutical compositions comprising them and their use for the treatment of cancer. The present invention also provides processes for the preparation of acid addition salts of sorafenib.

Claims (6)

1. Crystalline sorafenib hydrochloride of Formula III

characterized by X-ray diffraction peaks having d-spacing values at about 3.69, 3.63, 3.42, 3.39 and 3.05 Å.

2. Crystalline sorafenib hydrochloride of claim 1 further characterized by X-ray diffraction peaks having d-spacing values at about 6.40, 4.22, 4.06 and 3.60 Å.

3. Crystalline sorafenib hydrochloride of claim 1 characterized by DSC thermogram having endotherms at about 68[0.33]° C., 115[0.21]° C. and 152[0.74]° C.

4. Crystalline sorafenib hydrochloride of claim 1 characterized by X-ray diffraction spectrum, DSC thermogram, TGA and IR spectrum as depicted in FIGS. 1 , 2 , 3 and 4 , respectively.

5. A pharmaceutical composition comprising crystalline sorafenib hydrochloride of Formula III.

Assignments (3)
CORRECTIVE ASSIGNMENT TO CORRECT THE INCORRECT APPL. NO. 12/377,847 PREVIOUSLY RECORDED AT REEL: 027916 FRAME: 0176. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Sep 16, 2016
From: JARYAL, JAGDEV SINGH; SATHYANARAYANA, SWARGAM; THAPER, RAJESH KUMAR; PRASAD, MOHAN
To: RANBAXY LABORATORIES LIMITED
Reel/Frame 040054/0547 →
MERGER Recorded Jan 13, 2016
From: RANBAXY LABORATORIES LIMTED
To: SUN PHARMACEUTICAL INDUSTRIES LIMITED
Reel/Frame 037513/0475 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 23, 2012
From: JARYAL, JAGDEV SINGH; SATHYANARAYANA, SWARGAM; THAPER, RAJESH KUMAR; PRASAD, MOHAN
To: RANBAXY LABORATORIES LIMITED
Reel/Frame 027916/0176 →
Priority Claims (1)
IN 2008/DEL/2009 · Sep 24, 2009 · national
Continuity (1)
Related Publication 20120264789A1 · Oct 18, 2012