Method for producing a cross-linked polyacrylate polymer implant material
The invention relates to an implant material comprising a polymer which is partially cross-linked by means of a metal acrylate salt.
1. A method of producing an implant material, comprising the step of cross-linking a polymer with a polymerizable metal salt by dissolving said polymerizable metal salt in an acrylic monomer to produce a cross-linked polyacrylate polymer via polymerization.
2. The method of claim 1 , wherein said polymerizable metal salt is a metal acrylate.
3. The method of claim 2 , wherein said metal acrylate includes a metal selected from the group consisting of Ba, Sr, Mg, Zn, Sn, Cu, Zr, Fe, Cr, Mo, Mn, Co, Ti, and any combinations thereof.
4. The method of claim 1 , wherein said polymerizable metal salt is an acrylate having at least one four-valent central atom.
5. The method of claim 1 , wherein during said producing step, 10 to 50% of the polymerizable metal salt is used.
6. The method of claim 1 , further comprising the steps of:
producing partially cross-linked polymer particles of said partially cross-linked polymer;
partially dissolving or swelling said polymer particles in a monomer; and
polymerizing the implant material from said monomer, wherein said polymer particles are cross-linked with the partially cross-linked polymer.
7. The method of claim 1 , further comprising the step of adding said partially cross-linked polymer to a solvent, wherein portions of said partially cross-linked polymer that are not cross-linked are at least partially dissolved out and a porous structure is formed.
8. The method of claim 7 , further characterized in that between 20 and 80% of the volume of the implant material is dissolved out.
9. The method of claim 7 , wherein said porous structure is used as a support for an active substance.
10. The method of claim 1 , further 30 comprising the step of adding an initiator and an accelerator during said producing step.
11. The method of claim 10 , wherein said initiator is dibenzoyl peroxide, and said accelerator is dimethyl p-toluidine.
12. The method of claim 1 , wherein said acrylic monomer is a methacrylate.
13. The method of claim 1 , wherein said acrylic monomer is a methacrylic acid.