BONE CEMENT AND A METHOD FOR PRODUCING SAME
The invention relates to a bone cement composed of a hydrophilic component and a hydrophobic component, wherein biodegradable material is deposited in pores of the bone cement via the hydrophilic component.
1 . A bone cement, comprising:
at least one polymerizable hydrophobic component:
at least one hydrophilic component; and
biodegradable particles,
wherein said hydrophilic and said hydrophobic components are immiscible, and
wherein said biodegradable particles are contained at least partially in the hydrophilic component.
2 . The bone cement of claim 1 , wherein at least 50% of the biodegradable particles are contained in said hydrophilic component.
3 . The bone cement of claim 1 , wherein said hydrophobic component comprises an acrylate monomer.
4 . The bone cement of claim 1 , wherein said hydrophilic component comprises water and at least one of calcium carbonate, calcium sulfate, and calcium phosphate.
5 . The bone cement of claim 4 , wherein said hydrophilic component comprises hydroxyapatite.
6 . The bone cement of claim 1 , wherein said biodegradable material is present in nanoparticulate form.
7 . The bone cement of claim 1 , wherein said hydrophilic component comprises a system that starts a polymerization of the hydrophobic component.
8 . The bone cement of claim 1 , wherein said hydrophobic component comprises polymer particles.
9 . The bone cement of claim 8 , wherein said hydrophobic component further comprises a monomer, and said polymer particles are not completely soluble in said monomer.
10 . The bone cement of claim 1 , further comprising an x-ray contrast agent.
11 . The bone cement of claim 1 , further comprising a pharmaceutically active substance.
12 . The bone cement of claim 1 , wherein the bone cement comprises between 10% and 50% of said biodegradable particles, between 10% and 85% of said polymerizable hydrophobic component, and between 2 and 30% of said hydrophilic component.
13 . The bone cement of claim 1 , further comprising a polymer component and a liquid that is immiscible with the polymer component, wherein said biodegradable particles are in said liquid.
14 . The bone cement of claim 1 , further comprising:
10% to 50% of polymeric bone cement powder;
10% to 85% of a polar liquid;
a monomer;
an initiator; and
10% to 70% of said biodegradable particles.
15 . A cured bone cement comprising the bone cement of claim 1 , and further comprising a polymer backbone having open pores that are filled at least partially with biodegradable material.
16 . The cured bone cement of claim 15 , wherein said polymer backbone comprises an acrylate.
17 . The cured bone cement of claim 15 , wherein the cured bone cement has an E-modulus of less than 4500 MPa.
18 . The cured bone cement of claim 15 , wherein the cured bone cement has a porosity of between 5% and 90%.
19 . The cured bone cement of claim 15 , wherein the cured bone cement has an average pore size of between 5 μm and 5 mm.
20 . The cured bone cement of claim 15 , wherein said polymer backbone at least partially comprises a cross-linked polymer.
21 . The cured bone cement of claim 15 , wherein the cured bone cement is open-pore porous, and said biodegradable particles are in said open-pores.
22 . A method for producing the bone cement of claim 1 , comprising the step of mixing said polymerizable hydrophobic component with said hydrophilic component and said biodegradable material, so that said hydrophilic component forms at least partially open-pore regions, which are first filled with the hydrophilic component.
23 . The method of claim 22 , further comprising the steps of adding and mixing said biodegradable material and hydrophilic component as a suspension.
24 . The method of claim 22 , further comprising the step of adding said biodegradable material in the form of a nanoparticulate suspension and/or a suspension containing a dispersant.
25 . The method of claim 22 , further comprising the steps of adding and mixing at least one of calcium carbonate, calcium sulfate, and calcium phosphate as said biodegradable particles.
26 . The method of claim 22 , wherein during said mixing step, at least two pastes are used, and wherein said at least two pastes comprise a first paste containing said polymerizable hydrophobic component, and a second paste containing the biodegradable material and an initiator.
27 . The method of claim 26 , wherein said first paste comprises an accelerator.
28 . The method of claim 26 , wherein said first paste comprises polymer particles.
29 . The method of claim 22 , further comprising the step of producing said hydrophobic component with an acrylate.
30 . The method of claim 29 , further comprising the steps of precipitating said acrylate with (meth)acrylic acid, and producing said hydrophobic component with a powder that forms during said precipitating step.
31 . The method of claim 29 , wherein said acrylate is a metal acrylic salt.
32 . (canceled)