Diaryl ether derivatives as notch sparing gamma secretase inhibitors

1. A compound of formula I:

or a pharmaceutically acceptable salt thereof, wherein:

A represents —C(R 4 )(R 5 )— and B represent H, or A and B are joined together to form the following group:

Y and Z independently represent CR 11 or N, wherein R 11 is H or halogen;

X represents a bond, O or NR 2 ;

R 1 represents a linear, branched or cyclic, or combination thereof, hydrocarbon group of 1-10 carbon atoms, which is optionally substituted with up to 3 halogen atoms; or when X represents NR 2 , R 1 and R 2 together may complete a heterocyclic ring of up to 6 members which optionally bears up to 3 substituents independently selected from halogen, CF 3 , CHF 2 , CH 2 F, NO 2 , CN, OCF 3 , C 1-6 alkyl and C 1-6 alkoxy;

R 2 represents H or C 1-4 alkyl, or together with R 1 completes a heterocyclic ring as defined above;

R 3 represents H or C 1-4 alkyl;

R 4 represents C 1-6 alkyl,

R 5 represents H or C 1-6 alkyl;

or R 4 and R 5 may be joined together with the atom to which they are attached to form a spirocyclic ring of 3, 4 or 5 atoms, said ring optionally containing a heteroatom selected from O, S or N;

R 6 is bonded to one of the nitrogen atoms of the pyrazole ring and represents a hydrocarbon group of 1-5 carbon atoms which is optionally substituted with 1-3 substituents independently selected from R 8 ;

R 7 represents H, halogen, CN, formyl, phenylethynyl or C 1-6 alkyl;

Ar represents phenyl or 6-membered heteroaryl, either of which bears 0-3 substituents independently selected from R 8 ;

R 8 is selected from the group consisting of: halogen, OH, CN, R 10 , OR 9 , SR 10 , SO 2 R 10 , SO 2 N(R 9 ) 2 , COR 9 , CO 2 R 9 , CON(R 9 ) 2 , N(R 9 ) 2 , NO 2 , NR 9 COR 10 , NR 9 CO 2 R 9 , NR 9 CH 2 CO 2 R 9 , NR 9 SO 2 R 10 , —C 1-4 alkyl-N(R 9 ) 2 , —C 1-4 alkyl-NR 9 COR 10 , —C 1-4 alkyl-NR 9 CO 2 R 9 and —C 1-4 alkyl-NR 9 CH 2 CO 2 R 9 ;

each R 9 is independently selected from: (1) H, C 1-6 alkyl, C 3-10 cycloalkyl, C 3-10 cycloalkylC 1-4 alkyl, C 3-10 cycloalkenyl or C 3-10 cycloalkenylC 1-4 alkyl, any of which except H optionally bear up to 4 halogen atoms or with OH, CN, CF 3 and C 1-4 alkoxy, or both; (2) phenyl, benzyl, 5- or 6-membered monocyclic heteroaryl optionally bridged with a methylene or a 9- or 10-membered bicyclic heteroaryl optionally bridged with a methylene, any of which optionally bear up to 3 substituents independently selected from halogen, OH, CN, CF 3 , C 1-4 alkyl, C 3-6 cycloalkyl, phenyl, C 1-4 alkoxy, amino, C 1-4 alkylamino and di(C 1-4 -alkyl)amino; and (3) a nonaromatic or partially aromatic mono- or bicyclic heterocyclic system of up to 10 ring atoms, optionally bridged with a methylene and optionally bearing up to 3 substituents independently selected from halogen, OH, oxo, CN, CF 3 , C 1-4 alkyl, C 3-6 cycloalkyl, phenyl, a 5- or 6-membered monocyclic heteroaryl, C 1-4 alkoxy, acetyl, amino, C 1-4 alkylamino and di(C 1-4 alkyl)amino; or when two R 9 groups are attached to the same nitrogen atom they may be joined together with the nitrogen atom to complete a mono- or bicyclic heterocyclic ring of up to 10 members which optionally bears up to 3 substituents independently selected from halogen, CF 3 , CHF 2 , CH 2 F, NO 2 , CN, OCF 3 , acetyl, formyl, C 1-6 alkyl and C 1-6 alkoxy; and

R 10 has the same definition as R 9 except that R 10 is not H.

2. The compound according to claim 1 wherein R 6 is bonded to one of the nitrogen atoms of the pyrazole ring and represents a hydrocarbon group of 1-5 carbon atoms which is optionally substituted with up to 3 halogen atoms or hydroxy.

3. The compound according to claim 2 wherein Ar represent phenyl, which bears 0-3 substituents independently selected from R 8 .

4. The compound according to claim 3 wherein Ar represents 4-CF 3 -phenyl.

5. The compound according to claim 2 wherein R 6 is bonded to one of the nitrogen atoms of the pyrazole ring and represents ethyl.

6. The compound according to claim 2 wherein A represents —C(R 4 )(R 5 )— and B represent H.

7. The compound according to claim 6 wherein R 4 and R 5 are methyl.

8. The compound according to claim 6 wherein R 4 and R 5 are joined together with the atom to which they are attached to form cyclopropyl, cyclobutyl or oxetanyl.

9. The compound according to claim 2 wherein A and B are joined together to form the following group:

10. The compound according to claim 2 wherein X represents a bond.

11. The compound according to claim 10 wherein R 1 represent CF 3 —CH 2 —.

12. The compound according to claim 2 wherein X represents NR 2 .

13. The compound according to claim 2 wherein Y and Z each represent CH.

14. The compound according to claim 2 wherein:

Y and Z each represent CH;

Ar represent phenyl, which bears 0-3 substituents independently selected from R 8 ;

R 3 represents H;

R 6 is bonded to one of the nitrogen atoms of the pyrazole ring and represents ethyl;

R 7 represents H;

A represents —C(R 4 )(R 5 )— and B represent H;

R 4 and R 5 are methyl or R 4 and R 5 are joined together with the atom to which they are attached to form cyclopropyl, cyclobutyl or oxetanyl; and

X represents a bond or NR 2 .

15. The compound according to claim 1 wherein:

Y and Z each represent CH;

Ar represent phenyl, which bears 0-3 substituents independently selected from R 8 ;

R 3 represents H;

R 7 represents H;

A represents —C(R 4 )(R 5 )— and B represent H;

R 4 and R 5 are methyl or R 4 and R 5 are joined together with the atom to which they are attached to form cyclopropyl, cyclobutyl or oxetanyl; and

X represents a bond or NR 2 .

16. A compound selected from the following group:

N-[1-(3-{1-ethyl-5-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-3-yl}phenyl)-1-methylethyl]-2,2,2-trifluoroethanesulfonamide;

1-cyclobutyl-N-[1-(3-{1-ethyl-5-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-3-yl}phenyl)-1-methylethyl]methanesulfonamide;

N-cyclobutyl-N′-[1-(3-{1-ethyl-5-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-3-yl}phenyl)-1-methylethyl]sulfamide;

N-[1-(3-{1-ethyl-5-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-3-yl}phenyl)-1-methylethyl]-N′-(2,2,2-trifluoroethyl)sulfamide;

N-[1-(3-{1-ethyl-5-[2-fluoro-4-(trifluoromethyl)phenoxy]-1H-pyrazol-3-yl}phenyl)-1-methylethyl]-2,2,2-trifluoroethanesulfonamide;

N-[1-(3-{1-ethyl-5-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-3-yl}phenyl)-1-methylethyl]-2,2,2-trifluoroethanesulfonamide;

N-(1-{3-[1-ethyl-5-(2-fluorophenoxy)-1H-pyrazol-3-yl]phenyl}-1-methylethyl)-2,2,2-trifluoroethanesulfonamide;

N-[1-(3-{1-ethyl-5-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-3-yl}phenyl)-1-methylethyl]-N′-propylsulfamide;

N-[1-(3-{1-ethyl-5-[4-(trifluoromethyl) phenoxy]-1H-pyrazol-3-yl}phenyl)-1-methylethyl]-N′-isobutylsulfamide;

N-[1-(3-{1-ethyl-5-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-3-yl}phenyl)-1-methylethyl]-N′-methylsulfamide;

N-[1-(3-{1-ethyl-5-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-3-yl}phenyl)-1-methylethyl]pyrrolidine-1-sulfonamide;

N-[1-(3-{1-ethyl-5-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-3-yl}phenyl)-1-methylethyl]cyclopropanesulfonamide;

N-cyclopentyl-N′-[1-(3-{1-ethyl-5-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-3-yl}phenyl)-1-methylethyl]sulfamide;

N′-[1-(3-{1-ethyl-5-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-3-yl}phenyl)-1-methylethyl]-N,N-dimethylsulfamide;

N-[1-(3-{1-ethyl-5-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-3-yl}-5-fluorophenyl)-1-methylethyl]-2,2,2-trifluoroethanesulfonamide;

N-cyclobutyl-N′-[1-(3-{1-ethyl-3-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-5-yl}phenyl)-1-methylethyl]sulfamide;

N-[1-(3-{1-ethyl-3-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-5-yl}phenyl)-1-methylethyl]-N′-isobutylsulfamide;

N-cyclopentyl-N′-[1-(3-{1-ethyl-3-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-5-yl}phenyl)-1-methylethyl]sulfamide

N-[1-(3-{1-ethyl-3-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-5-yl}phenyl)-1-methylethyl]-N′-(2,2,2-trifluoroethyl)sulfamide;

N-[1-(3-{1-ethyl-3-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-5-yl}phenyl)-1-methylethyl]-2,2,2-trifluoroethanesulfonamide;

N-[1-(3-{1-ethyl-3-[2-fluoro-4-(trifluoromethyl)phenoxy]-1H-pyrazol-5-yl}phenyl)-1-methylethyl]-2,2,2-trifluoroethanesulfonamide;

N-[1-(3-{3-[(6-chloropyridin-3-yl)oxy]-1-ethyl-1H-pyrazol-5-yl}phenyl)-1-methylethyl]-2,2,2-trifluoroethanesulfonamide;

N-[1-(3-{1-ethyl-3-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-5-yl}phenyl)-1-methylethyl]-N′-propylsulfamide;

N-[1-(3-{1-ethyl-3-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-5-yl}phenyl)-1-methylethyl]-N′-methylsulfamide;

N′-[1-(3-{1-ethyl-3-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-5-yl}phenyl)-1-methylethyl]-N,N-dimethylsulfamide;

N-[1-(3-{1-ethyl-3-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-5-yl}phenyl)-1-methylethyl]pyrrolidine-1-sulfonamide;

N-[1-(3-{1-ethyl-3-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-5-yl}phenyl)-1-methylethyl]piperidine-1-sulfonamide;

N-[1-(3-{1-ethyl-5-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-3-yl}phenyl)cyclopropyl]-2,2,2-trifluoroethanesulfonamide;

N-cyclopentyl-N′-[1-(3-{1-ethyl-3-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-5-yl}phenyl)cyclopropyl]sulfamide;

N-[1-(3-{1-ethyl-3-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-5-yl}phenyl)cyclopropyl]-N′-isobutylsulfamide;

N-[1-(3-{1-ethyl-3-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-5-yl}phenyl)cyclopropyl]-2,2,2-trifluoroethanesulfonamide;

N-{1-[3-(1-ethyl-3-{[5-(trifluoromethyl)pyridin-2-yl]oxy}-1H-pyrazol-5-yl)phenyl]cyclopropyl}-2,2,2-trifluoroethanesulfonamide;

N-[1-(3-{1-ethyl-3-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-5-yl}phenyl)cyclopropyl]-N′-propylsulfamide;

N-[1-(3-{1-ethyl-3-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-5-yl}phenyl)cyclopropyl]-N′-methylsulfamide;

N-cyclopentyl-N′-[1-(3-{1-ethyl-5-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-3-yl}phenyl)cyclopropyl]sulfamide;

N-[1-(3-{1-ethyl-5-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-3-yl}phenyl)cyclopropyl]-N′-(2,2,2-trifluoroethyl)sulfamide;

1-cyclobutyl-N-[1-(3-{1-ethyl-5-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-3-yl}phenyl)cyclopropyl]methanesulfonamide;

N-[1-(3-{1-ethyl-5-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-3-yl}phenyl)cyclopropyl]ethanesulfonamide;

N-{1-[3-(5-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}-1-ethyl-1H-pyrazol-3-yl)phenyl]cyclopropyl}-2,2,2-trifluoroethanesulfonamide;

N-{1-[3-(1-ethyl-5-{[6-(trifluoromethyl)pyridin-3-yl]oxy}-1H-pyrazol-3-yl)phenyl]cyclopropyl}-2,2,2-trifluoroethanesulfonamide;

N-{1-[3-(1-ethyl-5-{[5-(trifluoromethyl)pyridin-2-yl]oxy}-1H-pyrazol-3-yl)phenyl]cyclopropyl}-N′-(2,2,2-trifluoroethyl)sulfamide;

1-cyclobutyl-N-{1-[3-(1-ethyl-5-{[5-(trifluoromethyl)pyridin-2-yl]oxy}-1H-pyrazol-3-yl)phenyl]cyclopropyl}methanesulfonamide;

N-cyclobutyl-N′-{1-[3-(1-ethyl-5-{[5-(trifluoromethyl)pyridin-2-yl]oxy}-1H-pyrazol-3-yl)phenyl]cyclopropyl}sulfamide;

N-{1-[3-(1-ethyl-5-{[5-(trifluoromethyl)pyridin-2-yl]oxy}-1H-pyrazol-3-yl)phenyl]cyclopropyl}-2,2,2-trifluoroethanesulfonamide;

N-{1-[3-(1-ethyl-5-{[5-(trifluoromethyl)pyridin-2-yl]oxy}-1H-pyrazol-3-yl)phenyl]cyclopropyl}-N′-methylsulfamide;

N-[1-(3-{1-ethyl-5-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-3-yl}phenyl)cyclopropyl]-N′-propylsulfamide;

N-[1-(3-{1-ethyl-5-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-3-yl}phenyl)cyclopropyl]-N′-isobutylsulfamide;

N-[1-(3-{1-ethyl-5-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-3-yl}phenyl)cyclopropyl]-N′-methylsulfamide;

N-[1-(3-{1-ethyl-5-[(5-fluoropyrimidin-2-yl)oxy]-1H-pyrazol-3-yl}phenyl)cyclopropyl]-2,2,2-trifluoroethanesulfonamide;

N-(1-{3-[1-ethyl-5-(pyridin-4-yloxy)-1H-pyrazol-3-yl]phenyl}cyclopropyl)-2,2,2-trifluoroethanesulfonamide;

N-[1-(6-{1-ethyl-5-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-3-yl}pyridin-2-yl)cyclopropyl]-2,2,2-trifluoroethanesulfonamide;

N-[1-(5-{1-ethyl-5-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-3-yl}pyridin-3-yl)cyclopropyl]-2,2,2-trifluoroethanesulfonamide;

N-(1-{3-[1-ethyl-3-(4-fluorophenoxy)-1H-pyrazol-5-yl]phenyl}-1-methylethyl)-2,2,2-trifluoroethanesulfonamide;

N-cyclobutyl-N′-(1-{3-[1-ethyl-3-(4-fluorophenoxy)-1H-pyrazol-5-yl]phenyl}-1-methylethyl)sulfamide;

N-(1-{3-[1-ethyl-3-(4-fluorophenoxy)-1H-pyrazol-5-yl]phenyl}-1-methylethyl)-N′-(2,2,2-trifluoroethyl)sulfamide;

N-(1-{3-[1-ethyl-5-(4-fluorophenoxy)-1H-pyrazol-3-yl]phenyl}-1-methylethyl)-2,2,2-trifluoroethanesulfonamide;

N-{1-[3-(1-ethyl-5-phenoxy-1H-pyrazol-3-yl)phenyl]-1-methylethyl}-2,2,2-trifluoroethanesulfonamide;

N-(1-{3-[1-ethyl-5-(4-isopropylphenoxy)-1H-pyrazol-3-yl]phenyl}-1-methylethyl)-2,2,2-trifluoroethanesulfonamide;

N-(1-{3-[1-ethyl-5-(4-methylphenoxy)-1H-pyrazol-3-yl]phenyl}-1-methylethyl)-2,2,2-trifluoroethanesulfonamide;

N-(1-{3-[5-(4-tert-butylphenoxy)-1-ethyl-1H-pyrazol-3-yl]phenyl}-1-methylethyl)-2,2,2-trifluoroethanesulfonamide;

N-(1-{3-[1-ethyl-5-(4-formylphenoxy)-1H-pyrazol-3-yl]phenyl}-1-methylethyl)-2,2,2-trifluoroethanesulfonamide;

N-[1-(3-{1-ethyl-5-[4-(hydroxymethyl)phenoxy]-1H-pyrazol-3-yl}phenyl)-1-methylethyl]-2,2,2-trifluoroethanesulfonamide;

N-[1-(3-{1-ethyl-5-[4-(fluoromethyl)phenoxy]-1H-pyrazol-3-yl}phenyl)-1-methylethyl]-2,2,2-trifluoroethanesulfonamide;

N-[1-(3-{5-[4-(difluoromethyl)phenoxy]-1-ethyl-1H-pyrazol-3-yl}phenyl)-1-methylethyl]-2,2,2-trifluoroethanesulfonamide;

N-[1-(3-{1-ethyl-5-[4-(1-hydroxyethyl)phenoxy]-1H-pyrazol-3-yl}phenyl)-1-methylethyl]-2,2,2-trifluoroethanesulfonamide;

N-[1-(3-{1-ethyl-5-[4-(1-hydroxy-2-methylpropyl)phenoxy]-1H-pyrazol-3-yl}phenyl)-1-methylethyl]-2,2,2-trifluoroethanesulfonamide;

N-[1-(3-{1-ethyl-5-[4-(1-hydroxypropyl)phenoxy]-1H-pyrazol-3-yl}phenyl)-1-methylethyl]-2,2,2-trifluoroethanesulfonamide;

N-[1-(3-{1-ethyl-5-[4-(1-fluoroethyl)phenoxy]-1H-pyrazol-3-yl}phenyl)-1-methylethyl]-2,2,2-trifluoroethanesulfonamide;

N-(1-{3-[5-(4-acetylphenoxy)-1-ethyl-1H-pyrazol-3-yl]phenyl}-1-methylethyl)-2,2,2-trifluoroethanesulfonamide;

N-[1-(3-{1-ethyl-5-[4-(1-hydroxy-1-methylethyl)phenoxy]-1H-pyrazol-3-yl}phenyl)-1-methylethyl]-2,2,2-trifluoroethanesulfonamide;

N-[1-(3-{1-ethyl-5-[4-(2,2,2-trifluoro-1-hydroxyethyl)phenoxy]-1H-pyrazol-3-yl}phenyl)-1-methylethyl]-2,2,2-trifluoroethanesulfonamide;

N-[1-(3-{1-ethyl-5-[4-(1,2,2,2-tetrafluoroethyl)phenoxy]-1H-pyrazol-3-yl}phenyl)-1-methylethyl]-2,2,2-trifluoroethanesulfonamide;

N-[1-(3-{1-ethyl-5-[4-(trifluoroacetyl)phenoxy]-1H-pyrazol-3-yl}phenyl)-1-methylethyl]-2,2,2-trifluoroethanesulfonamide;

4-({1-ethyl-3-[3-(1-methyl-1-{[(2,2,2-trifluoroethyl)sulfonyl]amino}ethyl)phenyl]-1H-pyrazol-5-yl}oxy)-N-(tetrahydrofuran-2-ylmethyl)benzamide;

N-[1-(3-{1-ethyl-5-[4-(5-methyl-1,3,4-oxadiazol-2-yl)phenoxy]-1H-pyrazol-3-yl}phenyl)-1-methylethyl]-2,2,2-trifluoroethanesulfonamide;

N-[1-(3-{1-ethyl-5-[4-(1,3-oxazol-5-yl)phenoxy]-1H-pyrazol-3-yl}phenyl)-1-methylethyl]-2,2,2-trifluoroethanesulfonamide;

N-(1-{3-[1-ethyl-5-(4-{[(tetrahydrofuran-2-ylmethyl)amino]methyl}phenoxy)-1H-pyrazol-3-yl]phenyl}-1-methylethyl)-2,2,2-trifluoroethanesulfonamide;

N-(1-{3-[1-ethyl-5-(4-{[(pyridin-2-ylmethyl)amino]methyl}phenoxy)-1H-pyrazol-3-yl]phenyl}-1-methylethyl)-2,2,2-trifluoroethanesulfonamide;

N-[1-(3-{1-ethyl-5-[4-(morpholin-4-ylmethyl)phenoxy]-1H-pyrazol-3-yl}phenyl)-1-methylethyl]-2,2,2-trifluoroethanesulfonamide;

N-{1-[3-(5-{4-[(benzylamino)methyl]phenoxy}-1-ethyl-1H-pyrazol-3-yl)phenyl]-1-methylethyl}-2,2,2-trifluoroethanesulfonamide;

N-(1-{3-[1-ethyl-5-(4-{[4-(trifluoromethyl)-3,6-dihydropyridin-1(2H)-yl]methyl}phenoxy)-1H-pyrazol-3-yl]phenyl}-1-methylethyl)-2,2,2-trifluoroethanesulfonamide;

methyl N-[4-({1-ethyl-3-[3-(1-methyl-1-{[(2,2,2-trifluoroethyl)sulfonyl]amino}ethyl)phenyl]-1H-pyrazol-5-yl}oxy)benzyl]glycinate;

N-(1-{3-[1-ethyl-5-(4-{[(4-methoxyphenyl)amino]methyl}phenoxy)-1H-pyrazol-3-yl]phenyl}-1-methylethyl)-2,2,2-trifluoroethanesulfonamide;

N-{1-[3-(1-ethyl-5-{4-[(isoxazol-3-ylamino)methyl]phenoxy}-1H-pyrazol-3-yl)phenyl]-1-methylethyl}-2,2,2-trifluoroethanesulfonamide;

N-[1-(3-{5-[4-(anilinomethyl)phenoxy]-1-ethyl-1H-pyrazol-3-yl}phenyl)-1-methylethyl]-2,2,2-trifluoroethanesulfonamide;

N-{1-[3-(1-ethyl-5-{4-[(pyridin-3-ylamino)methyl]phenoxy}-1H-pyrazol-3-yl)phenyl]-1-methylethyl}-2,2,2-trifluoroethanesulfonamide;

N-{1-[3-(1-ethyl-5-{4-[(1,3-thiazol-2-ylamino)methyl]phenoxy}-1H-pyrazol-3-yl)phenyl]-1-methylethyl}-2,2,2-trifluoroethanesulfonamide;

N-[1-(3-{5-[4-(1,4-dioxa-8-azaspiro[4.5]dec-8-ylmethyl)phenoxy]-1-ethyl-1H-pyrazol-3-yl}phenyl)-1-methylethyl]-2,2,2-trifluoroethanesulfonamide;

N-(1-{3-[1-ethyl-5-(4-{[(2-thienylmethyl)amino]methyl}phenoxy)-1H-pyrazol-3-yl]phenyl}-1-methylethyl)-2,2,2-trifluoroethanesulfonamide;

N-(1-{3-[1-ethyl-5-(4-{[(pyridin-4-ylmethyl)amino]methyl}phenoxy)-1H-pyrazol-3-yl]phenyl}-1-methylethyl)-2,2,2-trifluoroethanesulfonamide;

N-[1-(3-{1-ethyl-5-[4-({[(2-methyltetrahydrofuran-2-yl)methyl]amino}methyl)phenoxy]-1H-pyrazol-3-yl}phenyl)-1-methylethyl]-2,2,2-trifluoroethanesulfonamide;

N-(1-{3-[1-ethyl-5-(4-{[(tetrahydro-2H-pyran-4-ylmethyl)amino]methyl}phenoxy)-1H-pyrazol-3-yl]phenyl}-1-methylethyl)-2,2,2-trifluoroethanesulfonamide;

N-{1-[3-(1-ethyl-5-{4-[(tetrahydro-2H-pyran-3-ylamino)methyl]phenoxy}-1H-pyrazol-3-yl)phenyl]-1-methylethyl}-2,2,2-trifluoroethanesulfonamide;

N-{1-[3-(5-{4-[(4-acetylpiperazin-1-yl)methyl]phenoxy}-1-ethyl-1H-pyrazol-3-yl)phenyl]-1-methylethyl}-2,2,2-trifluoroethanesulfonamide;

N-(1-{3-[1-ethyl-5-(4-{[(pyridin-3-ylmethyl)amino]methyl}phenoxy)-1H-pyrazol-3-yl]phenyl}-1-methylethyl)-2,2,2-trifluoroethanesulfonamide;

N-[3-(3-{1-ethyl-5-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-3-yl}phenyl)oxetan-3-yl]-2,2,2-trifluoroethanesulfonamide;

N-[3-(3-{1-ethyl-5-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-3-yl}phenyl)oxetan-3-yl]-N′-(2,2,2-trifluoroethyl)sulfamide;

N-[3-(3-{1-ethyl-5-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-3-yl}phenyl)oxetan-3-yl]-N′-methylsulfamide;

N-[3-(3-{1-ethyl-3-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-5-yl}-phenyl)oxetan-3-yl]-2,2,2-trifluoroethanesulfonamide;

2,2,2-trifluoro-N-[1-(3-{1-(2-hydroxyethyl)-5-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-3-yl}phenyl)-1-methylethyl]ethanesulfonamide;

2,2,2-trifluoro-N-[1-(3-{1-methyl-5-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-3-yl}phenyl)cyclopropyl]ethanesulfonamide;

2,2,2-trifluoro-N-[1-(3-{1-(2,2,2-trifluoroethyl)-5-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-3-yl}phenyl)cyclopropyl]ethanesulfonamide;

N-(1-{3-[5-(4-cyanophenoxy)-1-ethyl-1H-pyrazol-3-yl]phenyl}-1-methylethyl)-2,2,2-trifluoroethanesulfonamide;

N-[1-(3-{1-ethyl-5-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-3-yl}phenyl)cyclobutyl]-2,2,2-trifluoroethanesulfonamide;

N-[1-(3-{1-ethyl-4-fluoro-3-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-5-yl}phenyl)cyclopropyl]-2,2,2-trifluoroethanesulfonamide;

N-[1-(3-{4-chloro-1-ethyl-5-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-3-yl}phenyl)cyclopropyl]-2,2,2-trifluoroethanesulfonamide;

N-[2-(3-{4-chloro-1-ethyl-5-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-3-yl}-phenyl)propan-2-yl]-2,2,2-trifluoroethanesulfonamide;

N-[2-(3-{4-chloro-1-ethyl-3-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-5-yl}-phenyl)propan-2-yl]-2,2,2-trifluoroethanesulfonamide;

N-[2-(3-{4-Bromo-1-ethyl-3-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-5-yl}phenyl)propan-2-yl]-2,2,2-trifluoroethanesulfonamide;

N-[2-(3-{4-bromo-1-ethyl-5-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-3-yl}phenyl)propan-2-yl]-2,2,2-trifluoroethanesulfonamide;

N-[2-(3-{1-ethyl-4-iodo-5-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-3-yl}phenyl)propan-2-yl]-2,2,2-trifluoroethanesulfonamide;

N-[2-(3-{4-cyano-1-ethyl-5-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-3-yl}phenyl)propan-2-yl]-2,2,2-trifluoroethanesulfonamide;

N-[2-(3-{1-ethyl-4-formyl-5-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-3-yl}phenyl)propan-2-yl]-2,2,2-trifluoroethanesulfonamide;

N-[2-(3-{1-ethyl-4-(phenylethynyl)-5-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-3-yl}phenyl)propan-2-yl]-2,2,2-trifluoroethanesulfonamide;

N-[5-(1-Ethyl-3-(4-trifluoromethylphenoxy)-1H-pyrazol-5-yl)-2,3-dihydro-1H-inden-2-yl]-N′-(2,2,2-trifluoroethyl)sulfuric diamide;

N-[5-(1-Ethyl-5-(4-trifluoromethylphenoxy)-1H-pyrazol-3-yl)-2,3-dihydro-1H-inden-2-yl]-N′-(2,2,2-trifluoroethyl)sulfuric diamide;

N-[5-(1-ethyl-3-{[5-(trifluoromethyl)pyridin-2-yl]oxy}-1H-pyrazol-5-yl)-2,3-dihydro-1H-inden-2-yl]-N′-(2,2,2-trifluoroethyl)sulfamide;

N-(5-{1-ethyl-3-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-5-yl}-2,3-dihydro-1H-inden-2-yl)-N′-propylsulfamide;

N-(5-{1-ethyl-3-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-5-yl}-2,3-dihydro-1H-inden-2-yl)-N′-isobutylsulfamide; and

N-cyclobutyl-N′-(5-{1-ethyl-3-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-5-yl}-2,3-dihydro-1H-inden-2-yl)sulfamide;

N-cyclopropyl-N-[3-(3-{1-ethyl-5-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-3-yl}phenyl)oxetan-3-yl]sulfamide;

N-(3,3-difluorocyclopentyl)-N-[3-(3-{1-ethyl-5-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-3-yl}phenyl)oxetan-3-yl]sulfamide;

N-[3-(3-{1-ethyl-3-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-5-yl}phenyl)oxetan-3-yl]-N′-(2,2,2-trifluoropropyl)sulfamide;

N-(cyclobutylmethyl)-N-[3-(3-{1-ethyl-3-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-5-yl}phenyl)oxetan-3-yl]sulfamide;

N-cyclopropyl-N-[3-(3-{1-ethyl-3-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-5-yl}phenyl)oxetan-3-yl]sulfamide;

N-[3-(5-{1-ethyl-5-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-3-yl}pyridine-3-yl)oxetan-3-yl]-2,2,2-trifluoroethanesulfonamide;

N-[3-(5-{1-ethyl-5-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-3-yl}pyridine-3-yl)oxetan-3-yl]-N′-(2,2,2-trifluoroethyl)sulfamide;

N-(3-{3-[5-(4-cyanophenoxy)-1-ethyl-1H-pyrazol-3-yl]phenyl}oxetane-3-yl)-2,2,2-trifluoroethanesulfonamide;

N-(3-{3-[5-(4-cyanophenoxy)-1-ethyl-1H-pyrazol-3-yl]phenyl}oxetane-3-yl)-N-(2,2,2-trifluoroethyl)sulfamide;

N-(3-{3-[5-(4-cyanophenoxy)-1-ethyl-1H-pyrazol-3-yl]phenyl}oxetane-3-yl)-N′-(3,3-difluorocyclobutyl)sulfamide;

2-[5-(4-trifluoromethylphenoxy)-3-(3-{3-[(2,2,2-trifluoroethylsulfonyl)amino]oxetan-3-yl}phenyl)-1H-pyrazol-1-yl]-N,N-dimethylacetamide;

2-[5-(4-trifluoromethylphenoxy)-3-(3-{3-[(2,2,2-trifluoroethylsulfonyl)amino]oxetan-3-yl}phenyl)-1H-pyrazol-1-yl]-N-methylacetamide;

N-[3-(3-{5-(4-trifluoromethylphenoxy)-1-[2-oxo-2-(morpholin-4-yl)ethyl]-1H-pyrazol-3-yl}phenyl)oxetan-3-yl]-2,2,2-trifluoroethanesulfonamide;

N-(3-{3-[5-(4-trifluoromethylphenoxy)-1-(1,3-oxazol-4-ylmethyl)-1H-pyrazol-3-yl]phenyl}oxetan-3-yl)-2,2,2-trifluoroethanesulfonamide;

N-(3-{3-[3-(4-trifluoromethylphenoxy)-1-(1,3-oxazol-4-ylmethyl)-1H-pyrazol-5-yl]phenyl}oxetan-3-yl)-2,2,2-trifluoroethanesulfonamide;

N-(3-{3-[5-(4-trifluoromethylphenoxy)-1-(5-methyl-1,3,4-oxadiazol-2-ylmethyl)-1H-pyrazol-3-yl]phenyl}oxetan-3-yl)-2,2,2-trifluoroethanesulfonamide;

N-(3-{3-[5-(4-trifluoromethylphenoxy)-1-(5-methyl-1,2-isoxazol-3-ylmethyl)-1H-pyrazol-3-yl]phenyl}oxetan-3-yl)-2,2,2-trifluoroethanesulfonamide;

N-(3-{3-[5-(4-trifluoromethylphenoxy)-1-(tetrahydrofuran-2-ylmethyl)-1H-pyrazol-3-yl]phenyl}oxetan-3-yl)-2,2,2-trifluoroethanesulfonamide;

N-(3-{3-[5-(4-trifluoromethylphenoxy)-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-pyrazol-3-yl]phenyl}oxetan-3-yl)-2,2,2-trifluoroethanesulfonamide;

N-(3-{3-[5-(4-trifluoromethylphenoxy)-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-pyrazol-2-yl]phenyl}oxetan-3-yl)-2,2,2-trifluoroethanesulfonamide;

N-(3-{3-[5-(4-trifluoromethylphenoxy)-1-(2-methoxyethyl)-1H-pyrazol-2-yl]phenyl}oxetan-3-yl)-2,2,2-trifluoroethanesulfonamide;

N-(3-{3-[5-(4-trifluoromethylphenoxy)-1-(3-methoxypropyl)-1H-pyrazol-2-yl]phenyl}oxetan-3-yl)-2,2,2-trifluoroethanesulfonamide;

or a pharmaceutically acceptable salt of any of the foregoing compounds.

17. A pharmaceutical composition comprising a compound according to claim 1 or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.