Composition and method for medical imaging of body cavities
A foamed aqueous image enhancing composition containing cellulose and/or cellulose derivative(s), has a pH between 5.5 and 7, wherein the viscosity of the composition is less than 1800 mPa·sec, and wherein a gas is maintained in the composition for at least 1 minute after preparation. The combination of low viscosity and foam stability makes the composition particularly suitable in patency tests and fallopian tube sterilization checks.
1. A method for enhancing contrast of an image of a body cavity, comprising:
(a) introducing a foamed aqueous image enhancing composition into a body cavity selected from uterus or fallopian tubes of a patient,
said composition comprising cellulose and/or a cellulose derivative, having a pH between 5.5 and 7, and having a viscosity of less than 1800 mPa·sec, as determined by standard viscosity determination methods, measured at room temperature and under atmospheric pressure, and
(b) scanning the patient using imaging technology,
wherein a gas is maintained in the composition for at least 1 minute after initiating foaming.
2. The method according to claim 1 , wherein said body cavity is the fallopian tubes.
3. The method according to claim 1 , wherein said method is used in a patency test or in a check on fallopian tube sterilization surgery.
4. The method according to claim 3 , wherein said surgery involves intratubal devices.
5. The method according to claim 1 , wherein the image enhancing composition has a viscosity of at least 15 mPa·s.
6. The method according to claim 1 , wherein the image enhancing composition has a viscosity of less than 1000 mPa·s.
7. The method according to claim 1 , wherein a 1-10 ml amount of the foamed aqueous image enhancing composition is introduced into the body cavity.
8. The method according to claim 1 , further comprising:
providing an aqueous image enhancing composition, said composition consisting essentially of 1-5 wt % of cellulose and/or cellulose derivative, glycerine and a buffer, and having a viscosity between 2000-4000 mPa·sec; and
foaming said composition with a combination of air and an aqueous solution to produce the foamed aqueous image enhancing composition, said foamed composition having a viscosity of less than 1800 mPa·sec and a pH between 5.5 and 7.