Protein Arginine Deiminase inhibitors as novel therapeutics for rheumatoid arthritis and cancer
In accordance with certain embodiments of the present disclosure, a self-assembling biodegradable nanoparticle is provided. The nanoparticle includes Cys-Val-Val-Val-Val-Val-Val-Lys-Lys conjugated with a synthetic polymer and has a diameter of from about 50 nm to about 150 nm.
1. An inactivator of protein arginine deiminase, the inactivator comprising:
wherein x comprises F, or Cl.
2. The inactivator of claim 1 , wherein x comprises F.
3. The inactivator of claim 1 , wherein x comprises Cl.
4. A method for inactivating protein arginine deiminase 4, the method comprising:
contacting protein arginine deiminase 4 with an inactivator, the inactivator comprising
wherein x comprises F or Cl.
5. The method of claim 4 , wherein x comprises F.
6. The method of claim 4 , wherein x comprises Cl.
7. The method of claim 4 , further comprising administering a chemotherapeutic agent with the inactivator.
8. The method of claim 4 , wherein the chemotherapeutic agent comprises doxorubicin.
9. The method as in claim 4 , wherein the method is performed in vivo.