Multifunctional small molecules
The present invention relates to dendrimer synthesis. Specifically, the present invention relates to triazine scaffolds capable of click chemistry for one-step synthesis of functionalized dendrimers, and methods of making and using the same.
1. A composition comprising a PAMAM dendrimer conjugated with a triazine compound, wherein said triazine compound is selected from the group consisting of
2. The composition of claim 1 , wherein said PAMAM dendrimer is conjugated with said triazine compound via a 3-azido-coumarine linkage agent.
3. The composition of claim 1 , wherein said triazine compound is conjugated with one or more ligands.
4. The composition of claim 3 , wherein said one or more ligands are independently selected from the group consisting of a therapeutic agent, a targeting agent, an imaging agent, and a trigger agent.
5. The composition of claim 3 , wherein said one or more ligands are methotrexate, folic acid, and 3-azido-coumarine.
6. A method of synthesizing a functionalized dendrimer, said method comprising:
a) providing an alkyne-modified PAMAM dendrimer and a triazine compound, wherein said triazine compound is selected from the group consisting of
and
b) conjugating said alkyne-modified PAMAM dendrimer with said triazine compound.
7. The method of claim 6 , wherein conjugating of said alkyne-modified PAMAM dendrimer with said triazine compound occurs via a click chemistry reaction.
8. The method of claim 6 , wherein said PAMAM dendrimer is conjugated with said triazine compound via a 3-azido-coumarine linkage agent.
9. The method of claim 6 , further comprising step c) conjugating one or more ligands with said triazine compound.
10. The method of claim 9 , wherein said one or more ligands are selected from the group consisting of a therapeutic agent, a targeting agent, an imaging agent, and a trigger agent.
11. The method of claim 9 , wherein said one or more ligands are methotrexate and folic acid.