Albumin variants
The present invention relates to variants of a parent albumin having altered plasma half-life compared with the parent albumin. The present invention also relates to fusion polypeptides and conjugates comprising said variant albumin.
1. A variant of albumin comprising a substitution in a position corresponding to position 573 in the amino acid sequence of SEQ ID NO:2, wherein the substitution is selected from the group consisting of K573A,C,D,F,G,H,I,L,M,N,P,Q,R,S, V,W, and Y, and wherein the variant has at least 98% sequence identity to the amino acid sequence of SEQ ID NO:2.
2. The variant of claim 1 , wherein the variant has at least 99% sequence identity to the amino acid sequence of SEQ ID NO:2.
3. The variant of claim 1 , wherein the variant consists of the amino acid sequence of SEQ ID NO:2 with a substitution at position 573.
4. The variant of claim 1 , wherein the substitution is K573A.
5. The variant of claim 1 , wherein the substitution is K573C.
6. The variant of claim 1 , wherein the substitution is K573D.
7. The variant of claim 1 , wherein the substitution is K573F.
8. The variant of claim 1 , wherein the substitution is K573G.
9. The variant of claim 1 , wherein the substitution is K573H.
10. The variant of claim 1 , wherein the substitution is K573I.
11. The variant of claim 1 , wherein the substitution is K573L.
12. The variant of claim 1 , wherein the substitution is K573M.
13. The variant of claim 1 , wherein the substitution is K573N.
14. The variant of claim 1 , wherein the substitution is K573P.
15. The variant of claim 1 , wherein the substitution is K573Q.
16. The variant of claim 1 , wherein the substitution is K573R.
17. The variant of claim 1 , wherein the substitution is K573S.
18. The variant of claim 1 , wherein the substitution is K573V.
19. The variant of claim 1 , wherein the substitution is K573W.
20. The variant of claim 1 , wherein the substitution is K573Y.