Substituted biaryl derivatives and methods of use thereof
View Patent ↗The present invention relates to Substituted Biaryl Derivatives, compositions comprising a Substituted Biaryl Derivative, and methods of using the Substituted Biaryl Derivatives for treating or preventing obesity, diabetes, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of GPR119 in a patient.
1. A compound having the formula:
or a pharmaceutically acceptable salt thereof, wherein E is:
each occurrence of R 6 is a ring carbon atom substituent and is independently selected from halo, —CF 3 , —OH, alkyl, C 3 -C 7 cycloalkyl and —O—alkyl;
R 15 is alkyl; and
m is 0 or 1.
2. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein each occurrence of R 6 is halo.
3. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein m is 1.
4. The compound of claim 1 , which is
5. A compound which is
or a pharmaceutically acceptable salt thereof.
6. A composition comprising one or more compounds of claim 1 or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable carrier.
7. The composition of claim 6 , further comprising one or more additional therapeutic agents, wherein the additional therapeutic agent(s) are selected from an antidiabetic agent and an antiobesity agent.
8. A method for treating diabetes in a patient, the method comprising administering to the patient an effective amount of one or more compounds of claim 1 , or a pharmaceutically acceptable salt thereof.
9. The method of claim 8 , further comprising administering to the patient one or more additional therapeutic agents, wherein the additional therapeutic agent(s) are selected from an antidiabetic agent and an antiobesity agent.
10. A compound having the structure:
or a pharmaceutically acceptable salt thereof.