IP Library Granted Patent US 9,034,083
Granted Patent B2
US 9,034,083 · App. 13/506,306 · Granted May 19, 2015

Array of hollow fibers and a system and method of manufacturing same

Inventors: Anna M Galea (Stow, MA); Kristen LeRoy (Somerville, MA); Nicholas Vitale (Albany, NY)
Assignee: Vivonics, Inc.
B01D63/04B01D67/00B01D63/02B01D63/021B01D63/022
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Quick Facts
Patent No.
US 9,034,083
App. No.
13/506,306
Granted
May 19, 2015
Kind
B2
Abstract

An array of hollow fibers including a plurality of hollow fibers of a predetermined diameter configured to receive a gas having oxygen therein and transfer the oxygen to a fluid and/or transfer carbon dioxide in the fluid to a gas. The array is configured in a predetermined pattern having a predetermined packing density that is a fraction of a total cross-sectional area of the array occupied by the hollow fibers.

Claims (59)

1. A method for manufacturing an array of hollow fibers, the method comprising:

a) providing an array manufacturing device including a base defining a bed and an adhesive applicator receivable in the base;

b) providing a plurality of shims each configured to fit into the bed;

c) providing a plurality of layers of hollow fibers;

d) placing the plurality of shims into the bed;

e) applying adhesive to the applicator;

f) positioning the applicator to contact and distribute the adhesive to a top shim of the plurality of shims in the bed;

g) placing a first layer of hollow fibers over the top shim with adhesive thereon;

h) rolling the adhesive away from a center portion of the first layer of hollow fibers;

i) removing one of the plurality of shims from the bed;

j) placing a next layer of hollow fibers over the first layer of hollow fibers;

k) applying adhesive to the adhesive applicator;

l) positioning the applicator to contact and distribute the adhesive to the next layer of hollow fibers;

m) rolling the adhesive away from a center portion of the next layer of hollow fibers; and

n) repeating at least steps i) through m) until an array having a predetermined number of layers is formed.

2. The method of claim 1 in which the adhesive applicator includes a plurality of blades and step of applying the adhesive includes applying the adhesive to the blades.

3. The method of claim 2 in which each of the blades includes a contact surface and the step of applying the adhesive includes applying the adhesive to the contact surface.

4. The method of claim 3 further including the step of pivotably attaching the adhesive applicator to the base.

5. The method of claim 1 further including the step of providing a roller to roll the adhesive away from the center portion.

6. The method of claim 1 further including the step of trimming excess adhesive from a completed array of hollow fibers.

7. A method for manufacturing an array of hollow fibers, the method comprising:

a) providing an array manufacturing device including a base defining a bed with opposing sides and an adhesive applicator receivable in the base;

b) providing a plurality of shims each sized to fit the opposing sides;

c) providing a plurality of layers of hollow fibers;

d) placing a pair of opposing shims adjacent to the opposing sides;

e) placing a layer of hollow fibers between the opposing shims;

f) applying adhesive to the opposing shims and the layer of hollow fibers;

g) rolling the adhesive away from a center portion of the layer of hollow fibers; and

h) repeating at least steps d) through g) until an array having a predetermined number of layers of hollow fibers is formed.

8. The method of claim 7 further including the step of pivotably attaching the adhesive applicator to the base.

9. A method of manufacturing an array of fibers, the method comprising:

a) providing a plurality of layers of hollow fibers;

b) providing first and second end-headers each including a plurality of recesses on one side configured to fit a layer of said plurality of hollow fibers;

c) providing a plurality of mid-headers each including a plurality of recesses on both sides configured to fit a layer of said plurality of hollow fibers;

d) applying adhesive to one end-header and one mid-header;

e) sandwiching one layer of said plurality of hollow fibers between the end-header and the mid-header;

f) applying adhesive to another mid-header;

g) sandwiching another layer of hollow fibers between two mid-headers;

h) repeating steps f) and g) a predetermined number of times;

i) applying adhesive to the second end-header; and

j) sandwiching a final layer of hollow fibers between the end-header and a last mid-header.

10. A system for manufacturing an array of hollow fibers, the system comprising:

an array manufacturing device including a base defining a bed and an adhesive applicator receivable in the base;

a plurality of shims each configured to fit into the base;

a plurality of layers of hollow fibers sized to fit into the base; and

a roller.

11. The system of claim 10 in which the adhesive applicator includes opposing arms and a plurality of blades therebetween.

12. The system of claim 11 in which each of the blades includes an adhesive contact surface.

13. The system of claim 10 in which the base is pivotably attached to the base.

14. The system of claim 10 in which each of the plurality of shims has a thickness approximately equal to the thickness of one of the plurality of layers of hollow fibers.

15. The system of claim 11 in which the plurality of blades form a predetermined shape.

16. The system of claim 15 in which the predetermined shape includes the shape of a lung.

17. The system of claim 15 in which the predetermined shape includes a rectangular shape.

18. A system for manufacturing an array of hollow fibers, the system comprising:

an array manufacturing device including a base defining a bed with opposing sides an adhesive applicator receivable in the base;

a plurality of layers of hollow fibers;

a plurality of shims each sized to fit the opposing sides; and

a roller.

19. The system of claim 18 in which the adhesive applicator is pivotably attached to the base.

Assignments (6)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 31, 2021
From: LUNG BIOTECHNOLOGY PBC
To: VIVONICS, INC.
Reel/Frame 055782/0790 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 17, 2016
From: VIVONICS, INC.
To: LUNG BIOTECHNOLOGY PBC
Reel/Frame 040360/0977 →
CONFIRMATORY LICENSE Recorded Dec 30, 2015
From: VIVONICS, INC.
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 037397/0992 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 31, 2013
From: INFOSCITEX CORPORATION
To: VIVONICS, INC.
Reel/Frame 029739/0408 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 25, 2012
From: ZIMMERMAN, SCOTT M.; LIVESAY, WILLIAM R.; ROSS, RICHARD L.; DEANDA, EDUARDO; LIVESAY, CHAD R.
To: GOLDENEYE, INC.
Reel/Frame 028521/0359 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 10, 2012
From: GALEA, ANNA M.; LEROY, KRISTEN; VITALE, NICHOLAS
To: INFOSCITEX CORPORATION
Reel/Frame 028162/0541 →
Continuity (1)
Related Publication 20130263739A1 · Oct 10, 2013