IP Library Granted Patent US 8,810,259
Granted Patent B2
US 8,810,259 · App. 13/509,313 · Granted Aug 19, 2014

Method of inspection of sealed capsules with a process of determination of the quality of the seal and related equipment for in-line inspection

Inventors: Hans-Rainer Herrmann (Hamburg, DE); Tom Regina Augustinus Huysmans (Bornem, BE); Udo Schlemm (Hamburg, DE)
Assignee: Capsugel Belgium NV
A61J3/072G01N22/04G01N33/15
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Quick Facts
Patent No.
US 8,810,259
App. No.
13/509,313
Granted
Aug 19, 2014
Kind
B2
Abstract

An exemplary embodiment of this invention relates to a method of inspection of a filled hard capsule sealed with a solvent sealing agent, including a process for determining the quality of the seal. The process may include: supplying a filled hard capsule sealed with a solvent sealing agent; supplying a microwave resonator wherein a measuring field having a resonance curve is generated; directing the capsule through the measuring field; measuring characteristics related to the modification of the resonance curve produced by the presence of the capsule in the measuring field, in comparison with a reference resonance curve corresponding to an empty state of the resonator; and using the measured characteristics to determine a value associated with the quality of the seal. Other exemplary embodiments of this invention relates to a method for sorting capsules on the basis of the result of the inspection method and to an associated equipment able to carry out such methods.

Claims (25)

1. Method of inspection of a filled hard capsule sealed with a solvent sealing agent, including a process for determining the quality of the seal, said process comprising:

supplying a filled hard capsule sealed with a solvent sealing agent;

generating a measuring field having a resonance curve with a microwave generator;

directing said capsule through the measuring field;

measuring characteristics related to a modification of the resonance curve produced by the presence of the capsule in the measuring field, in comparison with a reference resonance curve corresponding to an empty state of the resonator;

determining a seal area using said measured characteristics; and

determining a value associated with the quality of the seal using said measured characteristics.

2. Method according to claim 1 further including calculating a mass of the capsule as a function of said measured characteristics.

3. Method according to claim 2 , further including calculating the value associated with the quality of the seal as a function of at least one of said measured characteristics divided by said calculated mass.

4. Method according to claim 1 , wherein said measured characteristics comprise a shift and a broadening of the resonance curve produced by the presence of the capsule in the measuring field.

5. Method according to claim 1 , further including sorting capsules downstream from a hard capsule sealing equipment, wherein said capsule is rejected for sealing defect if the value associated with the quality of the seal is lower than a predetermined threshold value.

6. Equipment for inspecting a hard capsule sealed with a solvent sealing agent, comprising:

a microwave resonator adapted to generate a measuring field having a resonance curve and measure, when an object is directed through the measuring field, characteristics related to a modification of the resonance curve produced by the presence of the object in the measuring field, in comparison with a reference resonance curve corresponding to an empty state of the resonator;

a delivery device for singulating and directing individual capsules from a first section upstream the resonator to a second section downstream the resonator through the measuring field; and

a controller for calculating a value associated with a seal area as a function of said measured characteristics.

7. Equipment according to claim 6 , wherein said measured characteristics comprise a shift and a broadening of the resonance curve produced by the presence of the capsule in the measuring field.

8. Equipment according to claim 6 , wherein the controller is adapted to calculate a mass of the capsule as a function of said measured characteristics.

9. Equipment according to claim 8 , wherein the controller is adapted to calculate the value associated with the seal area as a function of at least one of said measured characteristics divided by said calculated mass.

10. Equipment according to claim 8 , wherein the controller further comprises a comparator adapted to compare, for each capsule,

(i) the value associated with the seal area with a predetermined threshold value and

(ii) the calculated value of the mass with a predetermined target range.

11. Equipment according to claim 10 , wherein the controller further comprises a rejection device adapted to divert the capsule from a normal path of capsules downstream the resonator if either:

(i) the value associated with the seal area is lower than the predetermined threshold value or

(ii) the calculated mass is out of the predetermined target range.

12. Equipment according to claim 6 , wherein the controller comprises a comparator adapted to compare, for each capsule, the value associated with the seal area with a predetermined threshold value and in that it further comprises a rejection device adapted to divert the capsule from a normal path of capsules downstream the resonator if the value associated with the quality of the seal is lower than the predetermined threshold value.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 28, 2014
From: PFIZER INC.
To: CAPSUGEL BELGIUM NV (FORMERLY KNOWN AS CAPSUGEL BELGIUM BVBA)
Reel/Frame 032319/0215 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 27, 2014
From: HERRMANN, RAINER; SCHLEMM, UDO; HUYSMANS, TOM REGINA AUGUSTINUS
To: PFIZER INC.
Reel/Frame 032315/0748 →
Continuity (2)
Provisional Application 61261002 · Nov 13, 2009
Related Publication 20120229147A1 · Sep 13, 2012