Methods of treating multiple sclerosis, rheumatoid arthritis and inflammatory bowel disease using agonists antibodies to PILR-α
View Patent ↗The present invention provides methods of using PILRα agonists, or PILRβ antagonists, to treat immune disorders, such as autoimmune and inflammatory disorders, including CNS, joint and gut inflammation.
1. A method of treating an immune disorder selected from the list consisting of multiple sclerosis, rheumatoid arthritis and inflammatory bowel disease, comprising administering to a subject in need of such treatment an effective amount of an antigen-binding domain from an agonist antibody that specifically binds to PILRα (SEQ ID NO: 2).
2. The method of claim 1 comprising administering an effective amount of an agonist antibody that specifically binds to PILRα.
3. The method of claim 2 wherein the agonist antibody that specifically binds to PILRα is a chimeric, humanized, or fully human antibody.
4. The method of claim 1 , wherein the immune disorder is multiple sclerosis.
5. The method of claim 1 , wherein the immune disorder is inflammatory bowel disease.
6. The method of claim 1 , wherein the immune disorder is rheumatoid arthritis.