IP Library Granted Patent US 8,868,202
Granted Patent B2
US 8,868,202 · App. 13/517,224 · Granted Oct 21, 2014

Implantable vestibular prosthesis

Inventors: Charles Coleman Della Santina (Towson, MD); Gene Yevgeny Fridman (Baltimore, MD); Bryce Chiang (Somerset, NJ)
Assignee: The Johns Hopkins University
A61N1/36A61B5/6847A61B5/11A61N1/0526A61B2562/0219A61N1/36032A61N1/0541
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Quick Facts
Patent No.
US 8,868,202
App. No.
13/517,224
Granted
Oct 21, 2014
Kind
B2
Abstract

An implantable nerve stimulation device has a sensor system, a data processor in communication with the sensor system, and a nerve stimulation system in communication with the data processor and constructed to provide electrical stimulation to at least one branch of at least one vestibulocochlear nerve. The nerve stimulation system includes an electrode array that has a first plurality of electrodes structured to be surgically implanted in electrical communication with a superior branch of the vestibular nerve, a second plurality of electrodes structured to be surgically implanted in electrical communication with a horizontal branch of the vestibular nerve, a third plurality of electrodes structured to be surgically implanted in electrical communication with a posterior branch of the vestibular nerve, and a common erus reference electrode structured to be surgically implanted into a common eras of the vestibular labyrinth.

Claims (31)

1. An implantable nerve stimulation device, comprising:

a sensor system;

a data processor in communication with said sensor system; and

a nerve stimulation system in communication with said data processor and constructed to provide electrical stimulation to at least one branch of at least one vestibulocochlear nerve,

wherein said nerve stimulation system comprises an electrode array, and

wherein said electrode array of said nerve stimulation system comprises a first plurality of electrodes structured to be surgically implanted in electrical communication with a superior branch of said vestibular nerve, a second plurality of electrodes structured to be surgically implanted in electrical communication with a horizontal branch of said vestibular nerve, a third plurality of electrodes structured to be surgically implanted in electrical communication with a posterior branch of said vestibular nerve, and a common crus reference electrode structured to be surgically implanted into a common crus of the vestibular labyrinth.

2. An implantable nerve stimulation device according to claim 1 , wherein said electrode array of said vestibular nerve stimulation system further comprises a second reference electrode structured to be fixed in electrical contact in a region external to said vestibular labyrinth.

3. An implantable nerve stimulation device according to claim 2 , wherein each plurality of electrodes are multi-electrode arrays structured to self-orient within the labyrinth to facilitate optimal implantation in electrical communication respectively with said branches of said vestibular nerve.

4. An implantable nerve stimulation device according to claim 1 , wherein said nerve stimulation system further comprises a plurality of current sources and a plurality of current sinks, each of which can be selectively directed to at least one electrode.

5. An implantable nerve stimulation device according to claim 1 , wherein said data processor is adapted to receive information to be used for corrections to stimulation of at least one of said superior, horizontal, and posterior branches of said vestibular nerve and to provide a corrected signal to said vestibular nerve stimulation system to effect current steering to improve electrical stimulation of said vestibular nerve.

6. An implantable nerve stimulation device according to claim 5 , further comprising a nonvolatile data storage system in communication with said data processor,

wherein said nonvolatile data storage system is configured to store data for use by said data processor to correct signals received from said sensor system.

7. An implantable nerve stimulation device according to claim 6 , wherein said data processor is configured to correct for at least one of misalignment between said implantable vestibular stimulation device and a head-fixed reference frame, misalignment of said electrode array with said vestibular nerve, and misalignment of head motion and eye motion responses or perception due to current spread during stimulation of said vestibular nerve.

8. An implantable nerve stimulation device according to claim 1 , wherein said sensor system comprises a three-axis gyroscope system.

9. An implantable nerve stimulation device according to claim 8 , wherein said sensor system further comprises a three-axis system of linear accelerometers constructed to provide at least orientation information of said implantable vestibular stimulation device for any orientation with respect to a local gravitational field.

10. An implantable nerve stimulation device according to claim 1 , wherein said electrode array of said nerve stimulation system further comprises a fourth plurality of electrodes structured to be surgically implanted in electrical communication with a utricular vestibular nerve branch, and a fifth plurality of electrodes structured to be surgically implanted in electrical communication with a saccule vestibular nerve branch.

11. An implantable nerve stimulation device according to claim 1 , wherein said electrode array of said nerve stimulation system further comprises a sixth plurality of electrodes structured to be surgically implanted in electrical communication with a cochlear nerve branch.

12. An implantable nerve stimulation device according to claim 1 , wherein at least one electrode of said first plurality of electrodes, said second plurality of electrodes, said third plurality of electrodes, and said common crus reference electrode is a chamber electrode comprising:

an electrically insulating structure defining a chamber and providing an opening for electrical contact with a nerve;

an electrically conducting structure disposed at least partially within said chamber; and

an electrolyte disposed in said chamber in electrical contact with said electrically conducting structure.

13. An implantable nerve stimulation device according to claim 1 , further comprising:

a data storage system in communication with said data processor,

wherein said sensor system comprises a rotational sensor system and an orientation sensor system both of which are fixed with respect to said implantable nerve stimulation device,

wherein said orientation sensor system senses an orientation of said implantable vestibular stimulation device relative to a local gravitational field to provide an orientation signal,

wherein said data processor is configured to generate an alignment transformation matrix based on said orientation signal and information regarding an orientation of a head-fixed reference frame of a head in which said implantable nerve stimulation device is implanted such that said alignment transformation matrix can be stored in said data storage system, and

wherein said data processor is configured to receive rotation signals from said rotational sensor system and correct said rotation signals using said alignment transformation matrix to provide corrected rotational signals to said implantable nerve stimulation system.

14. An implantable nerve stimulation device according to claim 13 , wherein said orientation sensor system comprises a three-axis system of linear accelerometers constructed to provide orientation information of said implantable vestibular stimulation device for any orientation with respect to said local gravitational field.

15. An implantable nerve stimulation device according to claim 14 , wherein said rotational sensor system comprises a three-axis gyroscope system.

16. An implantable nerve stimulation device according to claim 15 , wherein said three-axis system of linear accelerometers and said three-axis gyroscope system are micro electromechanical systems.

17. An implantable nerve stimulation device according to claim 12 , wherein said electrically conducting structure is at least one of a metal electrode, a metal wire, a metal foil, and a photolithographically defined trace.

Assignments (1)
CONFIRMATORY LICENSE Recorded Dec 12, 2017
From: JOHNS HOPKINS UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 044839/0405 →
Continuity (4)
Provisional Application 61294291 · Jan 12, 2010
Provisional Application 61301401 · Feb 4, 2010
Provisional Application 61410107 · Nov 4, 2010
Related Publication 20120277835A1 · Nov 1, 2012