COMBINATION FOR THE TREATMENT OF OSTEOARTHRITIS
The present invention relates to the use of a combination of glycine, proline, and optionally a natural or synthetic viscosity-controlling polymer, and/or lysine and/or leucine, to prepare a composition for the treatment of osteoarthritis.
1 . An intra-articular formulation for the treatment of osteoarthritis comprising:
a) glycine,
b) proline,
and optionally
c) a natural or synthetic viscosity-controlling polymer, and/or
d) lysine, and/or
e) leucine.
2 . The formulation as claimed in claim 1 , wherein osteoarthritis is patellofemoral or femorotibial knee osteoarthritis, hip osteoarthritis and shoulder osteoarthritis.
3 . The formulation as claimed in claim 1 , wherein the natural or synthetic viscosity-controlling polymer is selected from hyaluronic acid or a salt thereof, polyvinylpyrrolidone and cellulose derivatives.
4 . The formulation as claimed in claim 3 , wherein the natural or synthetic viscosity-controlling polymer is hyaluronic acid or a salt thereof.
5 . The formulation as claimed in claim 1 , wherein the amino acids are in L form.
6 . The formulation as claimed in claim 1 , wherein the various components of the combination are present in the following ranges by weight:
a) 25 to 500 mg of glycine,
b) 40 to 300 mg of proline,
and optionally
c) 5 to 50 mg of hyaluronic acid or a salt thereof, and/or
d) 5 to 100 mg of lysine, and/or
e) 5 to 50 mg of leucine.
7 . The formulation as claimed in claim 1 , in the form of powders for reconstitution or viscous solutions in biocompatible solvents.