Conjugate with target-finding ligand and use thereof
Described is a conjugate of agent complex and at least one target-finding ligand, where the agent complex comprises an agent encapsulated by an encapsulation material and where the target-finding ligand is a prostacyclin analog, and the use of the conjugate.
1. A conjugate of agent complex and at least one target-finding ligand, where the agent complex comprises a nanoparticle or nanocapsule comprising an agent encapsulated with biodegradable polyetheleneimine polymer encapsulation material and the target-finding ligand is iloprost or treprostinil, and wherein the target-finding ligand is not the agent.
2. The conjugate as claimed in claim 1 wherein the agent is a nucleic acid or a derivative thereof, a peptide, polypeptide or derivative thereof, an active substance or a tracer.
3. The conjugate as claimed in claim 2 , characterized in that the nucleic acid is a DNA or RNA whose lack or deficiency causes a disease or is a DNA or RNA which encodes a polypeptide whose lack or deficiency causes a disease or which has an immunomodulatory activity.
4. The conjugate as claimed in claim 2 , characterized in that the agent is a peptide or polypeptide whose lack or deficiency causes a disease or which has an immunomodulatory activity.
5. The conjugate of claim 1 , wherein the agent is a product which compensates for a protein defect or lack of protein and is nucleic acid, protein, protein derivative or protein fragment or a pharmaceutical which is active in the lungs or a mixture thereof.
6. The conjugate as claimed in claim 2 , characterized in that the active substance is an anti-inflammatory active substance or a steroid.
7. The conjugate of claim 1 , wherein the agent is a reporter molecule.
8. The conjugate of claim 1 , wherein an agent complex of encapsulation material and nucleic acid is additionally pegylated.
9. A method for treatment of a pulmonary disease caused by a protein or a genetic defect, comprising administering to a subject in need thereof the conjugate of an agent complex and at least one target-finding ligand of claim 1 .
10. The conjugate of claim 2 , wherein a ratio of polymer to nucleic acid measured as the molar ratio of polymer nitrogen content to DNA phosphate content is in a range of from 10:1 to 1:20.
11. A method of treatment of pulmonary diseases, comprising administering to a subject in need thereof an effective amount of the conjugate of an agent complex and at least one target-finding ligand of claim 1 .
12. The conjugate of claim 1 , further comprising customary pharmaceutical adjuvants in a form suitable for inhalation.
13. The conjugate of claim 7 , wherein the reporter molecule is a radioactive or fluorescent tracer.
14. The method of claim 9 , wherein the pulmonary disease is cystic fibrosis.