Pyrazolo[1,5-a]pyrimidine compounds as mTOR inhibitors
View Patent ↗The present invention provides Pyrazolopyrimidine Compounds of Formula (I): wherein L, T, Z, U, V, W, R 3 , R 6 , R 7 , R 8 , and m are as defined herein, and pharmaceutically acceptable salts of such Pyrazolopyrimidine Compounds. The Pyrazolopyrimidine Compounds are useful in the treatment of cancer and other diseases or disorders wherein mTOR is deregulated.
1. A compound having the Formula (I):
or a pharmaceutically acceptable salt thereof, wherein
U is N, CH, or C(R 13 );
R 13 is selected from the group consisting of
C 1 -C 6 alkyl, hydroxy, —OR 16 , —N(R 14 )(R 15 ), —N(R 14 )—C(O)—R 16 , —N(R 14 )—S(O)—R 16 , —N(R 14 )—S(O) 2 R 16 , —N(R 14 )—C(O)—N(R 14 )(R 15 ), C 3 -C 8 cycloalkyl, C 6 -C 10 mono or bicyclic aryl, —C(O)R 16 , —C(O)OR 16 , —C(O)N(R 14 )(R 15 ), —S(O)R 16 , —S(O) 2 R 16 , —S(O)—N(R 14 )(R 15 ), —S(O) 2 —N(R 14 )(R 15 ), —O—C(O)OR 17 , —O—C(O)N(R 17 )(R 18 ),
3- to 8-membered monocyclic heterocyclyl and having one to three heteroatoms selected from the group consisting of N, O, and S; and
C 5 -C 10 mono or bicyclic heteroaryl and having one to three heteroatoms selected from the group consisting of N, O, and S;
R 14 and R 15 are independently selected from the group consisting of H, C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, and phenyl;
R 16 is independently selected from the group consisting of C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, and phenyl;
R 17 and R 18 are independently selected from the group consisting of C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, C 6 -C 10 mono or bicyclic aryl, 3- to 8-membered monocyclic heterocyclyl, and C 5 -C 10 mono or bicyclic heteroaryl;
wherein L and Z are bonded to any two carbon atoms of the ring comprising U and are independently selected from the group consisting of CH 2 , C(H)(R 1 ), C(R 1 )(R 2 ), N(R 1 ), C(O), O, S, S(O), and S(O) 2 ; and T is absent such that L is bonded directly to Z, or T is selected from the group consisting of C(O), O, S, N(R 1 ), S(O), S(O) 2 , and C 1 -C 4 alkylene, wherein said alkylene of T is unsubstituted or substituted with 1 to 2 moieties, which moieties are independently selected from the group consisting of C 1 -C 3 alkyl, halo, hydroxy, C 1 -C 3 alkoxy, amino, C 1 -C 3 alkylamino and C 1 -C 3 dialkylamino; or L-T-Z is —CH 2 CH 2 OCH 2 —;
m is 0 or 1;
R 1 and R 2 are independently selected from the group consisting of H, C 1 -C 3 alkyl, halo, hydroxy, C 1 -C 3 alkoxy, amino, C 1 -C 3 alkylamino and C 1 -C 3 dialkylamino;
W is absent, or W is selected from the group consisting of C(O), C(NH), S(O), S(O) 2 , C 1 -C 4 alkylene, C 3 -C 8 cycloalkyl, phenyl, 5- to 6-membered heteroaryl, and 3- to 8-membered heterocyclyl;
V is absent, or V is selected from the group consisting of C(O), O, S, N(H), N(C 1 -C 3 alkyl), N(C 3 -C 8 cycloalkyl), S(O), S(O) 2 , and C 1 -C 4 alkylene;
or W and V together form a C 3 -C 8 cycloalkyl, phenyl, 5- to 6-membered heteroaryl, or 3 to 8-membered heterocyclyl ring;
R 8 is selected from the group consisting of
(i) C 1 -C 6 alkyl or C 3 -C 10 cycloalkyl, wherein said alkyl or cycloalkyl of R 8 is unsubstituted or substituted with one to three moieties independently selected from the group consisting of hydroxy, C 1 -C 6 alkoxy, halo, trifluoromethyl, carboxy, 5- to 6-membered heteroaryl, —SO 2 H, C 1 -C 6 alkyl-C(O)—NH—, C 1 -C 6 alkyl-SO 2 —NH—, and C 1 -C 6 alkyl-SO—NH—;
(ii) 3- to 8-membered heterocyclyl wherein said heterocyclyl of R 8 is unsubstituted or substituted with one to three moieties independently selected from the group consisting of halo, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, cyano, hydroxy, amino, C 1 -C 6 alkylamino, and C 1 -C 6 dialkylamino;
(iii) C 6 -C 10 aryl or 5- to 10-membered heteroaryl, wherein said aryl or heteroaryl of R 8 is unsubstituted or is substituted with one to three moieties independently selected from the group consisting of halo, trifluoromethyl, trifluoromethoxy, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, cyano, hydroxy, amino, C 1 -C 6 alkylamino, and C 1 -C 6 dialkylamino; and
(iv) —N(H)OH or —N(H)—C 1 -C 3 alkoxy;
R 3 is H, C 1 -C 6 alkyl, C 1 -C 6 alkenyl, C 1 -C 6 alkynyl, —C(O)R 9 , C 6 -C 12 aryl, C 3 -C 8 cycloalkyl, C 3 -C 8 cycloalkenyl, 5- to 10-membered heteroaryl, 3- to 8-membered heterocyclyl, 3- to 8-membered heterocyclenyl, (C 6 -C 12 )aryl(C 1 -C 6 )alkyl, (C 3 -C 8 )cycloalkyl(C 1 -C 6 )alkyl, (C 3 -C 8 )cycloalkenyl(C 1 -C 6 )alkyl, (5- to 10-membered) heteroaryl(C 1 -C 6 )alkyl, (3- to 8-membered)heterocyclyl(C 1 -C 6 )alkyl, (3- to 8-membered)heterocyclenyl(C 1 -C 6 )alkyl, wherein said aryl, cycloalkyl, cycloalkenyl, heteroaryl, heterocyclyl, heterocyclenyl, arylalkyl, cycloalkylalkyl, cycloalkenylalkyl, heteroarylalkyl, heterocyclylalkyl, and heterocyclenylalkyl of R 3 is unsubstituted or substituted with one to three moieties independently selected from the group consisting of Y, halogen, C 1 -C 6 alkyl, C 3 -C 10 cycloalkyl, trifluoromethyl, cyano, —C(O)OH, —(CH 2 ) x —C(O)OH, trifluoromethoxy, —OR 11 , —C(O)R 10 , —NR 9 R 10 , —C(O) 2 -alkyl, —C(O)NR 9 R 10 , —SR 9 , and —S(O) 2 R 12 ;
Y is C 6 -C 10 aryl or 5- to 10-membered heteroaryl, wherein said aryl or heteroaryl of Y is unsubstituted or substituted with one to five moieties independently selected from the group consisting of 2 H, halo, cyano, hydroxy, amino, C 1 -C 6 alkylamino, C 1 -C 6 dialkylamino, trifluoromethyl, trifluoromethoxy, C 1 -C 6 alkyl, C 1 -C 6 hydroxyalkyl, and C 1 -C 6 alkoxy; and
each occurrence of R 9 is independently H, C 1 -C 6 alkyl, C 3 -C 10 cycloalkyl, phenyl, 5- to 6-membered heteroaryl or 3- to 8-membered heterocyclyl;
each occurrence of R 10 is independently H, C 1 -C 6 alkyl, C 3 -C 10 cycloalkyl, phenyl, 5- to 6-membered heteroaryl, or 3- to 8-membered heterocyclyl, or R 9 and R 10 together with the nitrogen atom to which they are attached form a 3- to 6-membered heterocyclyl ring;
each occurrence of R 11 is independently H, C 1 -C 6 alkyl, C 3 -C 10 cycloalkyl, phenyl, 5- to 6-membered heteroaryl, or 3- to 8-membered heterocyclyl;
each occurrence of R 12 is independently C 1 -C 6 alkyl, C 3 -C 10 cycloalkyl, phenyl, 5- to 6-membered heteroaryl, or 3- to 8-membered heterocyclyl; and
x is an integer from 1 to 4;
R 6 is selected from the group consisting of H, halo, hydroxyl, cyano, C 1 -C 6 alkyl, C 1 -C 6 alkanoyl, C 1 -C 6 alkylsulfonyl, C 1 -C 6 alkylsulfinyl, C 1 -C 6 alkoxy, C 1 -C 6 haloalkyl, amino, C 1 -C 6 alkylamino, C 1 -C 6 dialkylamino, C 3 -C 8 cycloalkyl, C 6 -C 10 aryl, 5- to 10-membered heteroaryl, and 5- to 10-membered heterocyclyl, wherein each of said aryl, heteroaryl, and heterocyclyl of R 6 is unsubstituted or substituted with one to two moieties selected from the group consisting of halo, C 1 -C 3 alkyl, C 1 -C 3 alkoxy, amino, C 1 -C 3 alkylamino, and C 1 -C 3 dialkylamino; and
R 7 is selected from the group consisting of H, C 1 -C 6 alkyl, and C 3 -C 8 cycloalkyl, wherein said alkyl or cycloalkyl of R 7 is unsubstituted or substituted with one to two moieties selected from the group consisting of halo, C 1 -C 3 alkyl, C 1 -C 3 alkoxy, amino, C 1 -C 3 alkylamino, and C 1 -C 3 dialkylamino.
2. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein m is 1.
3. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein the group -L-T-Z— is selected from the group consisting of —CH 2 OCH 2 —, —CH 2 CH 2 OCH 2 —, and C 2 -C 4 alkylene, wherein said alkylene is unsubstituted or substituted with one to two moieties selected from the group consisting of C 1 -C 3 alkyl, fluoro, and hydroxy.
4. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein W is C(O).
5. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein V is absent.
6. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein R 8 is selected from the group consisting of
(i) C 1 -C 6 alkyl or C 3 -C 10 cycloalkyl, wherein said alkyl or cycloalkyl of R 8 is unsubstituted or substituted with one to three moieties independently selected from the group consisting of hydroxy, C 1 -C 6 alkoxy, fluoro, trifluoromethyl, carboxy, tetrazolyl, —SO 2 H, C 1 -C 6 alkyl-C(O)—NH—, C 1 -C 6 alkyl-SO 2 —NH—, and C 1 -C 6 alkyl-SO—NH—;
(ii) 5- to 6-membered heterocyclyl containing 1 to 3 heteroatoms selected from the group consisting of N, O, S, and S(O) 2 wherein said heterocyclyl of R 8 is unsubstituted or substituted with one to two moieties independently selected from the group consisting of halo, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, cyano, hydroxy, amino, C 1 -C 6 alkylamino, and C 1 -C 6 dialkylamino; and
(iii) phenyl or 5- to 6-membered heteroaryl containing 1 to 3 heteroatoms selected from the group consisting of N, O, and S, wherein said phenyl or heteroaryl of R 8 is unsubstituted or is substituted with one to two moieties independently selected from the group consisting of halo, trifluoromethyl, trifluoromethoxy, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, cyano, hydroxy, amino, C 1 -C 6 alkylamino, and C 1 -C 6 dialkylamino.
7. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein R 6 is selected from the group consisting of H, C 1 -C 6 alkyl, C 1 -C 6 alkanoyl, cyano, C 1 -C 6 alkylsulfonyl, halo, hydroxy, amino, C 1 -C 6 alkylamino, and C 1 -C 6 dialkylamino.
8. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein R 7 is H.
9. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound is:
10. A compound selected from the group consisting of:
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-3-hydroxy-2-(hydroxymethyl)-2-methylpropan-1-one;
((R)-1-((1R,3S,5S)-3-(6-acetyl-7-amino-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxypropan-1-one;
(R)-1-((1R,3S,5S)-3-(6-acetyl-7-amino-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2,3-dihydroxypropan-1-one;
(exo)-3-[6-acetyl-7-amino-3-(6-phenyl-3-pyridinyl)pyrazolo[1,5-a][pyrimidin-5-yl]-8-[(1,1-dioxido-3-isothiazolidinyl)carbonyl]-8-azabicyclo[3.2.1]octane;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxy-2-methylpropan-1-one;
1-(5-((1R,3s,5S)-8-(1H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
(S)-1-((1R,3R,5S)-3-(6-acetyl-7-amino-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxypropan-1-one;
1-((1R,3r,5S)-3-(6-acetyl-7-amino-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-(1H-tetrazol-5-yl)ethanone;
1-(5-((1R,3s,5S)-8-(1H-1,2,3-triazole-5-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(7-amino-5-((1R,3s,5S)-8-(3-methyl-1H-1,2,4-triazole-5-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
N-(2-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-oxoethyl)methanesulfonamide;
1-(5-((1R,3s,5S)-8-(1H-tetrazole-5-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
5-((1R,3s,5S)-8-(1H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidine-6-carboxamide;
1-(5-((1R,3s,5S)-8-(1H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(5-(difluoromethyl)thiazol-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(1H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(4-(pyrimidin-2-yl)phenyl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
5-(5-((1R,3s,5S)-8-(1H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-6-acetyl-7-aminopyrazolo[1,5-a]pyrimidin-3-yl)-N-methylpicolinamide;
5-(6-acetyl-7-amino-5-((1R,3s,5S)-8-(2-hydroxyacetyl)-8-azabicyclo[3.2.1]octan-3-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-N-methylpicolinamide;
1-(7-amino-5-((1R,3s,5S)-8-azabicyclo[3.2.1]octan-3-yl)-3-(6-(1-methyl-1H-pyrazol-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(5-hydroxy-6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(5-hydroxy-6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(6-(thiazol-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
(R)-1-((1R,3S,5S)-3-(6-acetyl-7-amino-3-(6-(thiazol-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxypropan-1-one;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(6-(thiazol-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxy-2-methylpropan-1-one;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(6-(3-(hydroxymethyl)-4-methoxyphenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(thiazol-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(7-fluoronaphthalen-2-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
(1R,3s,5S)-3-(6-acetyl-7-amino-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-N-methyl-8-azabicyclo[3.2.1]octane-8-carboxamide;
1-(7-amino-5-((1R,3s,5S)-8-(5-hydroxy-4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(1H-pyrrole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazol-3-ylsulfonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(1H-pyrrole-2-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(6-(4-methoxy-3-(methoxymethyl)phenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(4-methoxy-3-(methoxymethyl)phenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(4-methoxyphenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(2-fluoro-4-methoxyphenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(7-amino-5-((1R,3s,5S)-8-(1-hydroxycyclopropanecarbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
(1R,3s,5S)-3-(6-acetyl-7-amino-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octane-8-sulfonic acid;
1-(7-amino-5-((1R,3s,5S)-8-(5-hydroxynicotinoyl)-8-azabicyclo[3.2.1]octan-3-yl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(7-amino-5-((1R,3s,5S)-8-(4-hydroxynicotinoyl)-8-azabicyclo[3.2.1]octan-3-yl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(5-(methoxymethyl)thiazol-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(1H-imidazole-4-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3r,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(3-fluoro-4-methoxyphenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(1-methyl-1H-pyrazol-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(6-(1-methyl-1H-pyrazol-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-3-hydroxy-2-(hydroxymethyl)-2-methylpropan-1-one;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(3-fluoro-4-methoxyphenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(6-(3-fluoro-4-methoxyphenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(6-(3-fluoro-4-methoxyphenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-3-hydroxy-2-(hydroxymethyl)-2-methylpropan-1-one;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(6-(1-methyl-1H-pyrazol-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(2,3-difluorophenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(2′-fluoro-2,3′-bipyridin-5-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(3,5-difluoro-4-methoxyphenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(2,3-difluoro-4-methoxyphenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(4-methoxy-3-methylphenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(3-chloro-4-methoxyphenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(benzo[d][1,3]dioxol-5-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(4-(difluoromethoxy)phenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(4-fluoro-3-methoxyphenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(4-(2-methoxyethoxyl)phenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(2-methyl-2H-indazol-5-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(3-(6-(1H-benzo[d]imidazol-6-yl)pyridin-3-yl)-5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-aminopyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(2,5-difluoro-4-methoxyphenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(4-ethoxyphenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(3-(6-(1H-pyrazol-3-yl)pyridin-3-yl)-5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-aminopyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-((1R,3s,5S)-3-(3-(6-(1H-pyrazol-3-yl)pyridin-3-yl)-6-acetyl-7-aminopyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-(3-(2,4′-bipyridin-5-yl)-5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-aminopyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(4-methoxy-(D 3 )-phenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(6-(4-methoxy-(D 3 )-phenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-methylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
5-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-6-acetyl-7-aminopyrazolo[1,5-a]pyrimidin-3-yl)picolinic acid;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(1-methyl-(D 3 )-1H-pyrazol-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-(5-((1R,3s,5S)-8-(4H-1,2,4-thiazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-6-acetyl-7-aminopyrazolo[1,5-a]pyrimidin-3-yl)pyridin-2-yl)propan-1-one;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(6-(1-methyl-(D 3 )-1H-pyrazol-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(3-hydroxypentan-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(1-(fluoromethyl)-1H-pyrazol-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(6-(1-(fluoromethyl)-1H-pyrazol-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(1-methyl-1H-1,2,4-triazol-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(6-(1-methyl-1H-1,2,4-triazol-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(6-methylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-(3-(6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-aminopyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(6-(fluoromethyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(4-fluoro-1-methyl-1H-pyrazol-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(6-(4-fluoro-1-methyl-1H-pyrazol-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(5-methyl-1H-pyrazol-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(6-(5-methyl-1H-pyrazol-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-(3-(6-(1H-imidazol-4-yl)pyridin-3-yl)-5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-aminopyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-((1R,3s,5S)-3-(3-(6-(1H-imidazol-4-yl)pyridin-3-yl)-6-acetyl-7-aminopyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-ethylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3r,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(3,5-difluorophenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-((1R,3r,5S)-3-(6-acetyl-7-amino-3-(6-(3,5-difluorophenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-((1R,3s,5S)-3-(3-(6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-6-acetyl-7-aminopyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-(5-((1R,3r,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(3-fluorophenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(trifluoromethyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-((1R,3r,5S)-3-(6-acetyl-7-amino-3-(6-(3-fluorophenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(4-fluoro-1-methyl-1H-pyrazol-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(6-(4-fluoro-5-methyl-1H-pyrazol-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(1-methyl-1H-imidazol-4-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
(1R,3s,5S)-2-methoxyethyl 3-(6-acetyl-7-amino-3-(6-(1-methyl-1H-pyrazol-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octane-8-carboxylate;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(5-fluoro-6-(1H-pyrazol-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(5-fluoro-6-(1H-pyrazol-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(5-fluoro-6-(1-methyl-1H-pyrazol-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(5-fluoro-6-(1-methyl-1H-pyrazol-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(5-methyl-6-(1-methyl-1H-pyrazol-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(5-methyl-6-(1-methyl-1H-pyrazol-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-(5-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-6-acetyl-7-aminopyrazolo[1,5-a]pyrimidin-3-yl)pyridin-2-yl)pyridin-2(1H)-one;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)propane-1,2-dione;
2-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-oxoacetamide;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(5-fluoropyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(2-methyl-2H-indazol-6-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(1H-pyrazole-5-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(1-methyl-1H-pyrazol-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(7-amino-5-((1R,3s,5S)-8-(morpholine-4-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(1-(4-fluorophenyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
5-(5-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-6-acetyl-7-aminopyrazolo[1,5-a]pyrimidin-3-yl)pyridin-2-yl)-2-methoxybenzonitrile;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-methoxyquinolin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(hydroxymethyl)quinolin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(6-(5-methyl-1H-imidazol-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(4-methyl-1H-imidazol-1-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(3-(6-(1H-imidazol-1-yl)pyridin-3-yl)-5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-aminopyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(7-amino-5-((1R,3s,5S)-8-(5-amino-4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-3-(6-(4-methyl-1H-pyrazol-1-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(1H-pyrazole-5-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(4-methyl-1H-pyrazol-1-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(7-amino-5-((1R,3s,5S)-8-(3-amino-1H-pyrazole-5-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-3-(6-(4-methyl-1H-pyrazol-1-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(6-(3-methyl-1H-pyrazol-1-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(6-(4-methyl-1H-pyrazol-1-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-thiazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(4-methyl-1H-pyrazol-1-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-thiazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(3-methyl-1H-pyrazol-1-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(6-(1-ethyl-1H-pyrazol-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-thiazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(1-ethyl-1H-pyrazol-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(7-amino-5-((1R,3s,5S)-8-(5-(dimethylamino)-1H-1,2,4-thiazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(7-amino-5-((1R,3s,5S)-8-(5-amino-1H-1,2,4-thiazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(7-amino-5-((1R,3s,5S)-8-(5-amino-1H-pyrazole-4-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
N-(3-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octane-8-carbonyl)-1H-1,2,4-triazol-5-yl)acetamide;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-thiazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(1-phenyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(7-amino-5-((1R,3s,5S)-8-(5-amino-4H-1,2,4-thiazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-3-(6-(3-fluoro-4-methoxyphenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-thiazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(2-fluorophenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(3-(2,2′-bipyridin-5-yl)-5-((1R,3s,5S)-8-(4H-1,2,4-thiazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-aminopyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(2,6-difluorophenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(2,4-difluorophenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(1-methyl-1H-pyrazol-4-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(1-(2-hydroxyethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(1-(2-hydroxyethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(7-amino-5-((1R,3s,5S)-8-(3-amino-1H-pyrazole-5-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-3-(6-(4-fluorophenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(1H-pyrazole-5-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(4-fluorophenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
(R)-1-((1R,3S,5S)-3-(6-acetyl-7-amino-3-(6-(4-fluorophenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxypropan-1-one;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(6-(4-fluorophenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-(7-amino-3-(6-(4-fluorophenyl)pyridin-3-yl)-5-((1R,3s,5S)-8-(5-methyl-4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(1-(pyridin-2-yl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(1-(pyridin-2-yl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(4-fluorophenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(6-(2,4-difluorophenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-(7-amino-3-(6-(2,4-difluorophenyl)pyridin-3-yl)-5-((1R,3s,5S)-8-(5-methyl-4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(7-amino-5-((1R,3s,5S)-8-(3-amino-1H-pyrazole-5-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-3-(6-(2,4-difluorophenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(1H-pyrazole-5-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(2,4-difluorophenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
(R)-1-((1R,3S,5S)-3-(6-acetyl-7-amino-3-(6-(2,4-difluorophenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxypropan-1-one;
(1R,3s,5S)-3-(6-acetyl-7-amino-3-(6-(2,4-difluorophenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide;
(1R,3s,5S)-3-(6-acetyl-7-amino-3-(6-(4-fluorophenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(6-(2,6-difluorophenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(6-(2-fluorophenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-(7-amino-3-(6-(2-fluorophenyl)pyridin-3-yl)-5-((1R,3s,5S)-8-(5-methyl-4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
(1R,3s,5S)-3-(6-acetyl-7-amino-3-(6-(2-fluorophenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide;
(1R,3s,5S)-3-(6-acetyl-7-amino-3-(6-(1-methyl-1H-pyrazol-4-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide;
1-(7-amino-5-((1R,3s,5S)-8-(3-amino-1H-pyrazole-5-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-3-(6-(1-methyl-1H-pyrazol-4-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(3-(6-(1H-pyrazol-1-yl)pyridin-3-yl)-5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-aminopyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-((1R,3s,5S)-3-(3-(6-(1H-pyrazol-1-yl)pyridin-3-yl)-6-acetyl-7-aminopyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(2-phenylpyrimidin-5-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(5-chloro-6-(2-hydroxypropan-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3r,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-fluoro-8-methoxyquinolin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-((1R,3r,5S)-3-(6-acetyl-7-amino-3-(6-fluoro-8-methoxyquinolin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(5-(hydroxymethyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(1H-benzo[d]imidazol-5-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
((1R,3s,5S)-3-(7-amino-6-bromo-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(1H-1,2,4-triazol-3-yl)methanone;
1-((1R,3s,5S)-3-(7-amino-6-bromo-3-(6-(3-(hydroxymethyl)-4-methoxyphenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
(R)-1-((1R,3S,5S)-3-(7-amino-6-bromo-3-(6-(3-(hydroxymethyl)-4-methoxyphenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxypropan-1-one;
((1R,3s,5S)-3-(7-amino-6-bromo-3-(6-(3-fluoro-4-methoxyphenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-(3-fluoro-4-methoxyphenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-(3-(hydroxymethyl)-4-methoxyphenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
1-((1R,3s,5S)-3-(7-amino-3-(6-(3-(hydroxymethyl)-4-methoxyphenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-((1R,3s,5S)-3-(7-amino-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-((1R,3s,5S)-3-(7-1-((1R,3s,5S)-3-(7-amino-3-(6-(1-methyl-1H-1,2,4-triazol-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
((1R,3s,5S)-3-(7-amino-3-(6-(1-methyl-1H-1,2,4-triazol-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-(3-fluoro-4-methoxyphenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(1H-indazol-5-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(1H-1,2,4-triazol-5-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(1H-1,2,4-triazol-5-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(1H-indazol-6-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(1H-1,2,4-triazol-5-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(1H-indazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(1H-1,2,4-triazol-5-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-(2-fluorophenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-(2-fluoro-4-(trifluoromethyl)phenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3S,5S)-3-(7-amino-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)((R)-pyrrolidin-2-yl)methanone;
((1R,3R,5S)-3-(7-amino-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)((S)-pyrrolidin-2-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(morpholin-3-yl)methanone;
((1R,3S,5S)-3-(7-amino-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)((R)-piperidin-2-yl)methanone;
5-((1R,3s,5S)-8-azabicyclo[3.2.1]octan-3-yl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine;
1-((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(1H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(1H-1,2,3-triazol-5-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(3-methyl-1H-1,2,4-triazol-5-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(1H-tetrazol-5-yl)methanone;
5-(5-((1R,3s,5S)-8-(1H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-3-yl)-2-phenylpyridine 1-oxide;
(R)-1-((1R,3S,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2,3-dihydroxypropan-1-one;
(1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-N-ethyl-8-azabicyclo[3.2.1]octane-8-carboxamide;
(1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide;
(1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-N-cyclopropyl-8-azabicyclo[3.2.1]octane-8-carboxamide;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(1-hydroxycyclopropyl)methanone;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(3-hydroxypyridin-2-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4-hydroxypyridin-2-yl)methanone;
1-((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-3,3,3-trifluoro-2-hydroxypropan-1-one;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(5-hydroxypyridin-2-yl)methanone;
5-(5-((1R,3s,5S)-8-(1H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-3-yl)-N-methylpicolinamide;
5-((1R,3s,5S)-8-(1H-tetrazol-5-yl)-8-azabicyclo[3.2.1]octan-3-yl)-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine;
(1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octane-8-carbaldehyde;
5-((1R,3s,5S)-8-(5-methyl-4H-1,2,4-triazol-3-yl)-8-azabicyclo[3.2.1]octan-3-yl)-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine;
5-((1R,3s,5S)-8-(4H-1,2,4-triazol-3-yl)-8-azabicyclo[3.2.1]octan-3-yl)-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine;
((1R,3s,5S)-3-(7-amino-3-(5-hydroxy-6-phenylpyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
1-((1R,3s,5S)-3-(7-amino-3-(5-hydroxy-6-phenylpyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-(thiazol-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(7-fluoronaphthalen-2-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
5-((1R,3s,5S)-8-(4H-1,2,4-triazol-3-ylsulfonyl)-8-azabicyclo[3.2.1]octan-3-yl)-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine;
(S)-1-((1R,3R,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxypropan-1-one;
(R)-1-((1R,3S,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxypropan-1-one;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(5-hydroxy-4H-1,2,4-triazol-3-yl)methanone;
(1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-N-methyl-8-azabicyclo[3.2.1]octane-8-carboxamide;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(4-(pyridin-2-yl)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-(2-fluoro-4-methoxyphenyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-(4-methoxyphenyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-(4-methoxyphenyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(5-methyl-4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-(5-methoxythiophen-2-yl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
1-((1R,3s,5S)-3-(7-amino-3-(6-(4-methoxyphenyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
((1R,3s,5S)-3-(7-amino-3-(6-(3-fluoro-4-methoxyphenyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
1-((1R,3s,5S)-3-(7-amino-3-(6-(3-fluoro-4-methoxyphenyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
((1R,3s,5S)-3-(7-amino-3-(6-(3,4-dimethoxyphenyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-(1-methyl-1H-pyrazol-3-yl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
5-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-3-yl)-2-(1-methyl-1H-pyrazol-3-yl)pyridine 1-oxide;
((1R,3s,5S)-3-(7-amino-3-(6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
1-((1R,3s,5S)-3-(7-amino-3-(6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
((1R,3s,5S)-3-(7-amino-3-(6-(3,4-difluorophenyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-(3-fluoro-4-methylphenyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-(3-fluorophenyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-(2,3-difluorophenyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(3′-fluoro-2,2′-bipyridin-5-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-(3,5-difluoro-4-methoxyphenyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-(4-methoxy-3-methylphenyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-(3-chloro-4-methoxyphenyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-(benzo[d][1,3]dioxol-5-yl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-(2,3-difluoro-4-methoxyphenyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-(4-(difluoromethoxy)phenyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-(4-(2-methoxyethoxyl)phenyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-(2-methyl-2H-indazol-5-yl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-(2-methoxypyrimidin-5-yl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-(2,5-difluoro-4-methoxyphenyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-(4-ethoxyphenyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-(4-cyclopropoxyphenyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-(4-methoxy-(D 3 )-phenyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-(4-(fluoromethoxy)phenyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(3-(2,4′-bipyridin-5-yl)-7-amino-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
1-((1R,3s,5S)-3-(3-(2,4′-bipyridin-5-yl)-7-amino-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
((1R,3s,5S)-3-(7-amino-3-(6-butylpyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
1-((1R,3s,5S)-3-(7-amino-3-(6-(4-methoxy-(D 3 )-phenyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
((1R,3s,5S)-3-(7-amino-3-(6-methylpyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-(1-methyl-(D 3 )-1H-pyrazol-3-yl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
1-((1R,3s,5S)-3-(7-amino-3-(6-(1-methyl-(D 3 )-1H-pyrazol-3-yl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-(2-methoxyethoxyl)ethanone;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(3-(trifluoromethyl)-1H-pyrazol-5-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(1H-pyrazol-5-yl)methanone;
(3-amino-1H-pyrazol-5-yl)((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(1H-pyrrolo[3,2-c]pyridin-2-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(1H-pyrrolo[2,3-b]pyridin-2-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(1H-imidazol-2-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(1H-benzo[d]imidazol-2-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(3-methyl-1H-pyrazol-4-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(3-methyl-1H-pyrazol-5-yl)methanone;
1-((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-(3-methyl-1H-1,2,4-triazol-5-yl)ethanone;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(1H-pyrazol-4-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(3-(hydroxymethyl)-1H-pyrazol-5-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(3-(aminomethyl)-1H-pyrazol-5-yl)methanone;
((1R,3S,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)((R)-morpholin-3-yl)methanone;
((1R,3R,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)((S)-morpholin-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(1-(4-fluorophenyl)-1H-pyrazol-4-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
N-(5-((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octane-8-carbonyl)-4H-1,2,4-triazol-3-yl)acetamide;
(5-amino-1H-pyrazol-4-yl)((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)methanone;
1-((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2,2,2-trifluoroethanone;
5-(5-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-3-yl)pyridin-2-yl)-2-methoxybenzonitrile;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(5-(dimethylamino)-4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(5-hydroxy-1H-pyrazol-4-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(7-(hydroxymethyl)quinolin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(2-(2-methyl-2H-indazol-5-yl)pyrimidin-5-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(1-phenyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
(3-amino-1H-1,2,4-triazol-5-yl)((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(3-(trifluoromethyl)-1H-1,2,4-triazol-5-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-(3-fluoro-4-methoxyphenyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(5-amino-4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(2-phenylpyrimidin-5-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(2H-1,2,3-triazol-4-yl)methanone;
((1R,3s,5S)-3-(3-(2,2′-bipyridin-5-yl)-7-amino-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
2-(5-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-3-yl)pyridin-2-yl)pyridine 1-oxide;
((1R,3s,5S)-3-(7-amino-3-(6-(2-fluorophenyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-(4-fluorophenyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-(1-methyl-1H-pyrazol-4-yl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-(2,6-difluorophenyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-(2,4-difluorophenyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(3-(6-(1H-pyrazol-4-yl)pyridin-3-yl)-7-amino-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-(2-fluoro-4-(trifluoromethyl)phenyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(1-methyl-1H-pyrazol-4-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
1-((1R,3s,5S)-3-(7-amino-3-(1-methyl-1H-pyrazol-4-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
1-((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(5-methyl-4H-1,2,4-triazol-3-yl)methanone;
(3-amino-1H-pyrazol-5-yl)((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(1H-pyrazol-5-yl)methanone;
1-((1R,3s,5S)-3-(7-amino-3-(6-(4-fluorophenyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
((1R,3s,5S)-3-(7-amino-3-(6-(4-fluorophenyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(5-methyl-4H-1,2,4-triazol-3-yl)methanone;
(3-amino-1H-pyrazol-5-yl)((1R,3s,5S)-3-(7-amino-3-(6-(4-fluorophenyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-(4-fluorophenyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(1H-pyrazol-5-yl)methanone;
(R)-1-((1R,3S,5S)-3-(7-amino-3-(6-(4-fluorophenyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxypropan-1-one;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(1-(pyridin-2-yl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
1-((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(1-(pyridin-2-yl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
(1R,3s,5S)-3-(7-amino-3-(6-(2,4-difluorophenyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide;
(1R,3s,5S)-3-(7-amino-3-(6-(4-fluorophenyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide;
((1R,3s,5S)-3-(7-amino-3-(6-(2,4-difluorophenyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(5-methyl-4H-1,2,4-triazol-3-yl)methanone;
1-((1R,3s,5S)-3-(7-amino-3-(6-(2,4-difluorophenyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
(3-amino-1H-pyrazol-5-yl)((1R,3s,5S)-3-(7-amino-3-(6-(2,4-difluorophenyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)methanone;
(1R,3s,5S)-3-(7-amino-3-(6-(2-fluorophenyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-N-ethyl-8-azabicyclo[3.2.1]octane-8-carboxamide;
(1R,3s,5S)-3-(7-amino-3-(6-(2-fluorophenyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide;
1-((1R,3s,5S)-3-(7-amino-3-(6-(2-fluorophenyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
((1R,3s,5S)-3-(7-amino-3-(6-(2-fluorophenyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(5-methyl-4H-1,2,4-triazol-3-yl)methanone;
(3-amino-1H-pyrazol-5-yl)((1R,3s,5S)-3-(7-amino-3-(6-(2-fluorophenyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-(2-fluorophenyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(1H-pyrazol-5-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(2-phenylpyrimidin-5-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
(2-amino-4-methylpyrimidin-5-yl)((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)methanone;
4-((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octane-8-carbonyl)oxazol-2(3H)-one;
4-((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octane-8-carbonyl)-1H-imidazol-2(3H)-one;
6-((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octane-8-carbonyl)pyridin-2(1H)-one;
(S)-4-((1R,3R,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octane-8-carbonyl)oxazolidin-2-one;
(R)-4-((1R,3S,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octane-8-carbonyl)oxazolidin-2-one;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(2-aminopyrimidin-4-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(2-aminopyridin-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4-aminopyrimidin-5-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(3-aminopyrazin-2-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(2-(3-fluoro-4-methoxyphenyl)pyrimidin-5-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(2-(2,3-difluoro-4-methoxyphenyl)pyrimidin-5-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
1-((1R,3s,5S)-3-(7-amino-3-(2-(2,3-difluoro-4-methoxyphenyl)pyrimidin-5-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
((1R,3s,5S)-3-(3-(6-(1H-pyrazol-1-yl)pyridin-3-yl)-7-amino-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(imidazo[1,2-a]pyrimidin-6-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(2-(2-hydroxypropan-2-yl)pyrimidin-5-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
1-((1R,3s,5S)-3-(3-(6-(1H-pyrazol-1-yl)pyridin-3-yl)-7-amino-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(tetrahydro-2H-pyran-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
4-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-3-yl)-2-fluorobenzamide;
4-(7-amino-5-((1R,3s,5S)-8-(2-hydroxyacetyl)-8-azabicyclo[3.2.1]octan-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-3-yl)-2-fluorobenzamide;
((1R,3s,5S)-3-(7-amino-3-(6-(2-hydroxypropan-2-yl)-5-methylpyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(5-chloro-6-(2-hydroxypropan-2-yl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-(pyrimidin-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-(cyclopropylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-(ethylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-phenylpyridin-3-yl)-6-(propylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-(isopropylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6′-methoxy-2,3′-bipyridin-5-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-cyclohexylpyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-cyclopentylpyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-cyclobutylpyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(1H-1,2,4-triazol-5-yl)methanone;
1-((1R,3s,5S)-3-(7-amino-3-(6-cyclobutylpyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
((1R,3s,5S)-3-(7-amino-3-(6-(3-fluoro-4-methoxyphenyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(2H-1,2,3-triazol-4-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-(2-fluorophenyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(2H-1,2,3-triazol-4-yl)methanone;
(1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-N-methoxy-8-azabicyclo[3.2.1]octane-8-carboxamide;
(1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-N-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxamide;
((1R,3s,5S)-3-(7-amino-3-(6-(2,6-difluorophenyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(1H-1,2,3-triazol-5-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-(1-methyl-1H-pyrazol-3-yl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(2H-1,2,3-triazol-4-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(2-phenylpyrimidin-5-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(2H-1,2,3-triazol-4-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(1-phenyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(2H-1,2,3-triazol-4-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-fluoroquinolin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(2H-1,2,3-triazol-4-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(1-(4-fluorophenyl)-1H-pyrazol-4-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(2H-1,2,3-triazol-4-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-(pyrimidin-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(2H-1,2,3-triazol-4-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-(5-methylthiazol-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-(5-methylthiazol-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(2H-1,2,3-triazol-4-yl)methanone;
1-((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-(5-methylthiazol-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)ethanone;
(3-(7-amino-6-(methylsulfonyl)-3-(6-(5-methylthiazol-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(5-methyl-1H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-(5-methylthiazol-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(5-methyl-4H-1,2,4-triazol-3-yl)methanone;
1-((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-(5-methylthiazol-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-(5-methylthiazol-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(1-hydroxycyclopropyl)methanone;
1-((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-(5-methylthiazol-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-3,3,3-trifluoro-2-hydroxypropan-1-one;
2-amino-1-((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-(5-methylthiazol-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-3,3,3-trifluoropropan-1-one;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-(4-methylthiazol-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(2H-1,2,3-triazol-4-yl)methanone;
1-((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-(4-methylthiazol-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)ethanone;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-(4-methylthiazol-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(5-methyl-4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-(4-methylthiazol-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-(5,6-dihydro-4H-cyclopenta[d]thiazol-2-yl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-(5,6-dihydro-4H-cyclopenta[d]thiazol-2-yl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(1H-1,2,3-triazol-5-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-(5,6-dihydro-4H-cyclopenta[d]thiazol-2-yl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(5-methyl-4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-(4,5-dimethylthiazol-2-yl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
(3-(7-amino-3-(6-(4,5-dimethylthiazol-2-yl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(5-methyl-1H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-(4,5-dimethylthiazol-2-yl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(1H-1,2,3-triazol-5-yl)methanone;
(3-(7-amino-6-(methylsulfonyl)-3-(6-(2-methylthiazol-4-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(5-methyl-1H-1,2,4-triazol-3-yl)methanone;
1-((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-(2-methylthiazol-4-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-(2-methylthiazol-4-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(2H-1,2,3-triazol-4-yl)methanone;
5-((1R,3s,5S)-8-azabicyclo[3.2.1]octan-3-yl)-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine;
N-(2-((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-oxoethyl)acetamide;
N-(2-((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-oxoethyl)-2,2,2-trifluoroacetamide;
((1R,3S,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)((R)-pyrrolidin-2-yl)methanone;
((1R,3R,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)((S)-pyrrolidin-2-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(5-methyl-4H-1,2,4-triazol-3-yl)methanone;
5-((1R,3s,5S)-8-(4H-1,2,4-triazol-3-ylsulfonyl)-8-azabicyclo[3.2.1]octan-3-yl)-6-cyclopropyl-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine;
(1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-N-methyl-8-azabicyclo[3.2.1]octane-8-carboxamide;
(1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-N-ethyl-8-azabicyclo[3.2.1]octane-8-carboxamide;
(1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide;
(1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-N-(2-methoxyethyl)-8-azabicyclo[3.2.1]octane-8-carboxamide;
(1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-N-(2-hydroxyethyl)-8-azabicyclo[3.2.1]octane-8-carboxamide;
((1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(6-(3-fluoro-4-methoxyphenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(6-(2,3-difluoro-4-methoxyphenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(6-(4-fluoro-3-methoxyphenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(6-(2,5-difluoro-4-methoxyphenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(6-(4-ethoxyphenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(6-(4-(2-methoxyethoxyl)phenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(6-(4-(difluoromethoxy)phenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(6-methylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(6-(1-methyl-1H-pyrazol-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
1-((1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(6-(1-methyl-1H-pyrazol-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
((1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(6-(4-fluoro-5-methyl-1H-pyrazol-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
1-((1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(6-(4-fluoro-5-methyl-1H-pyrazol-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
((1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(6-(3-fluorophenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
1-((1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(6-(3-fluorophenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
((1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(6-(1-methyl-1H-imidazol-4-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(6-methoxyquinolin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(3-chlorophenyl)methanone;
((1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(1-phenyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
(5-amino-4H-1,2,4-triazol-3-yl)((1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(6-(3-fluoro-4-methoxyphenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)methanone;
N-(5-((1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octane-8-carbonyl)-4H-1,2,4-triazol-3-yl)acetamide;
((1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(5-(dimethylamino)-4H-1,2,4-triazol-3-yl)methanone;
(3-amino-1H-pyrazol-4-yl)((1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(5-(2-methoxyethylamino)-4H-1,2,4-triazol-3-yl)methanone;
(1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-N-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxamide;
(1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-N-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxamide;
7-amino-5-((1R,3s,5S)-8-(2-hydroxyacetyl)-8-azabicyclo[3.2.1]octan-3-yl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidine-6-carbonitrile;
5-((1R,3s,5S)-8-(1H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidine-6-carbonitrile;
5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(thiazol-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidine-6-carbonitrile;
((1R,3s,5S)-3-(7-amino-6-(methoxymethyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
(3-amino-1H-pyrazol-5-yl)((1R,3s,5S)-3-(7-amino-6-(methoxymethyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-(methoxymethyl)-3-(6-(4-methoxyphenyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-(hydroxymethyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-ethyl-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-ethyl-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(3-methyl-1H-1,2,4-triazol-5-yl)methanone;
1-((1R,3s,5S)-3-(3-(6-(1H-imidazol-2-yl)pyridin-3-yl)-7-amino-6-cyclopropylpyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
((1R,3s,5S)-3-(3-(6-(1H-imidazol-2-yl)pyridin-3-yl)-7-amino-6-cyclopropylpyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
1-((1R,3s,5S)-3-(3-(6-(1H-imidazol-2-yl)pyridin-3-yl)-6-acetyl-7-aminopyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-(3-(6-(1H-imidazol-2-yl)pyridin-3-yl)-5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-aminopyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-((1R,3s,5S)-3-(3-(6-(1H-imidazol-2-yl)pyridin-3-yl)-7-amino-6-ethylpyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-((1R,3s,5S)-3-(3-(6-(1H-imidazol-2-yl)pyridin-3-yl)-7-amino-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-((1R,3s,5S)-3-(3-(6-(1H-imidazol-2-yl)pyridin-3-yl)-7-amino-6-(prop-1-en-2-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
(S)-1-((1R,3R,5S)-3-(3-(6-(1H-imidazol-2-yl)pyridin-3-yl)-6-acetyl-7-aminopyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxypropan-1-one;
2-((1R,3s,5S)-3-(3-(6-(1H-imidazol-2-yl)pyridin-3-yl)-6-acetyl-7-aminopyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-oxoethyl acetate;
1-(3-(6-(1H-imidazol-2-yl)pyridin-3-yl)-7-amino-5-((1R,3s,5S)-8-(methylsulfonyl)-8-azabicyclo[3.2.1]octan-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(3-(6-(1H-imidazol-2-yl)pyridin-3-yl)-5-((1R,3s,5S)-8-(1H-pyrrole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-aminopyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
(R)-1-((1R,3S,5S)-3-(3-(6-(1H-imidazol-2-yl)pyridin-3-yl)-6-acetyl-7-aminopyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxypropan-1-one;
1-((1R,3s,5S)-3-(3-(6-(1H-imidazol-2-yl)pyridin-3-yl)-6-acetyl-7-aminopyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-(2-methoxyethoxyl)ethanone;
((1R,3s,5S)-3-(3-(6-(1H-imidazol-2-yl)pyridin-3-yl)-7-amino-6-cyclopropylpyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(1H-pyrrol-3-yl)methanone;
(1R,3s,5S)-3-(3-(6-(1H-imidazol-2-yl)pyridin-3-yl)-6-acetyl-7-aminopyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octane-8-carbaldehyde;
1-((1R,3s,5S)-3-(3-(6-(1H-imidazol-2-yl)pyridin-3-yl)-6-acetyl-7-aminopyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-methoxyethanone;
1-(3-(6-(1H-imidazol-2-yl)pyridin-3-yl)-7-amino-5-((1R,3s,5S)-8-(3-amino-1H-pyrazole-5-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(3-(6-(1H-imidazol-2-yl)pyridin-3-yl)-5-((1R,3s,5S)-8-acetyl-8-azabicyclo[3.2.1]octan-3-yl)-7-aminopyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(3-(6-(1H-imidazol-2-yl)pyridin-3-yl)-7-amino-5-((1R,3s,5S)-8-(tetrahydrofuran-2-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(3-(6-(1H-imidazol-2-yl)pyridin-3-yl)-7-amino-5-((1R,3s,5S)-8-(5-amino-4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(3-(6-(1H-imidazol-2-yl)pyridin-3-yl)-7-amino-5-((1R,3s,5S)-8-(5-methyl-4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-((1R,3s,5S)-3-(3-(6-(1H-imidazol-2-yl)pyridin-3-yl)-6-acetyl-7-aminopyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-fluoroethanone;
1-((1R,3s,5S)-3-(3-(6-(1H-imidazol-2-yl)pyridin-3-yl)-6-acetyl-7-aminopyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-fluoropropan-1-one;
(1R,3s,5S)-3-(3-(6-(1H-imidazol-2-yl)pyridin-3-yl)-6-acetyl-7-aminopyrazolo[1,5-a]pyrimidin-5-yl)-N-methyl-8-azabicyclo[3.2.1]octane-8-carboxamide;
(1R,3s,5S)-methyl 3-(3-(6-(1H-imidazol-2-yl)pyridin-3-yl)-6-acetyl-7-aminopyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octane-8-carboxylate;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(6-(5-methyl-1H-imidazol-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-((1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(6-(5-methyl-1H-imidazol-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(5-fluoro-6-(1H-imidazol-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-((1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(5-fluoro-6-(1H-imidazol-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
(1R,3s,5S)-3-(3-(6-(1H-imidazol-2-yl)pyridin-3-yl)-6-acetyl-7-aminopyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide;
(1R,3s,5S)-3-(3-(6-(1H-imidazol-2-yl)pyridin-3-yl)-7-amino-6-cyclopropylpyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide;
1-((1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(6-(4,5-dimethyl-1H-imidazol-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-((1R,3s,5S)-3-(3-(6-(1H-imidazol-2-yl)-5-methylpyridin-3-yl)-6-acetyl-7-aminopyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-(3-(6-(1H-imidazol-2-yl)-5-methylpyridin-3-yl)-5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-aminopyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-((1R,3s,5S)-3-(3-(4-(1H-imidazol-2-yl)phenyl)-7-amino-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
((1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(3-fluoro-4-(1H-imidazol-2-yl)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
1-((1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(3-fluoro-4-(1H-imidazol-2-yl)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(3-fluoro-4-(5-methyl-1H-imidazol-2-yl)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(3-fluoro-4-(5-methyl-1H-imidazol-2-yl)phenyl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(3-fluoro-4-(1H-imidazol-2-yl)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(3-fluoro-4-(1H-imidazol-2-yl)phenyl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-((1R,3s,5S)-3-(3-(4-(1H-imidazol-2-yl)phenyl)-6-acetyl-7-aminopyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-(3-(4-(1H-imidazol-2-yl)phenyl)-5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-aminopyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-((1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(6-(4-fluoro-1H-imidazol-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-((1R,3s,5S)-3-(3-(6-(1H-imidazol-2-yl)pyridin-3-yl)-6-acetyl-7-aminopyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-3-hydroxy-2,2-dimethylpropan-1-one;
1-((1R,3s,5S)-3-(3-(6-(1H-imidazol-2-yl)pyridin-3-yl)-6-acetyl-7-aminopyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-3-hydroxy-2-(hydroxymethyl)-2-methylpropan-1-one;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(hydroxymethyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(1-hydroxybutyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(1-hydroxypropyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(1-hydroxyethyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(1H-1,2,4-triazole-5-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(1-hydroxy-3-methylbutyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(7-amino-5-((1R,3s,5S)-8-(1-hydroxycyclopropanecarbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-3-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-(7-amino-3-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-5-((1R,3s,5S)-8-(5-methyl-4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(1H-1,2,3-triazole-5-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(1H-pyrazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(1H-pyrazole-4-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(7-amino-5-((1R,3s,5S)-8-(5-amino-4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-3-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-((R)-1-hydroxyethyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(7-amino-5-((1R,3s,5S)-8-(5-amino-1H-pyrazole-4-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-3-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(1H-pyrrole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(7-amino-3-(6-(1-hydroxycyclobutyl)pyridin-3-yl)-5-((1R,3s,5S)-8-(3-methyl-1H-1,2,4-triazole-5-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(6-(1-hydroxycyclobutyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-(5-((1R,3s,5S)-8-(1H-1,2,3-triazole-5-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(1-hydroxycyclobutyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(1H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(4-(1-hydroxyethyl)phenyl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(4-((R)-1-hydroxyethyl)phenyl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(4-((S)-1-hydroxyethyl)phenyl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(6-(2-hydroxypropan-2-yl)-5-methylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(2-hydroxypropan-2-yl)-5-methylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
((1R,3s,5S)-3-(7-amino-3-(6-(1-hydroxybutyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-(1-hydroxypropyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(1H-1,2,4-triazol-5-yl)methanone;
1-((1R,3s,5S)-3-(7-amino-3-(6-(1-hydroxycyclobutyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
((1R,3s,5S)-3-(7-amino-3-(6-(1-hydroxycyclobutyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(3-methyl-1H-1,2,4-triazol-5-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-(1-hydroxycyclobutyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(1H-1,2,3-triazol-5-yl)methanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-((2-methoxyethoxy)methyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
((1R,3s,5S)-3-(7-amino-3-(6-((2-methoxyethoxy)methyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-((R)-1-hydroxyethyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-((S)-1-hydroxyethyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
((1R,3s,5S)-3-(7-amino-3-(6-(hydroxymethyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(2-(1-hydroxyethyl)thiazol-5-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
((1R,3s,5S)-3-(7-amino-3-(2-(1-hydroxyethyl)thiazol-5-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(1-hydroxycyclobutyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
((1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(1-hydroxycyclobutyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
((1R,3s,5S)-3-(7-amino-3-(6-(1-hydroxycyclobutyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-bromo-3-(6-(1-hydroxycyclobutyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(6-(1-hydroxycyclobutyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-(1-hydroxycyclobutyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(3-hydroxyoxetan-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
((1R,3s,5S)-3-(7-amino-3-(6-(1-hydroxycyclopentyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
1-((1R,3s,5S)-3-(7-amino-3-(6-(1-hydroxycyclopentyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
((1R,3s,5S)-3-(7-amino-3-(6-(3-hydroxyoxetan-3-yl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
1-((1R,3s,5S)-3-(7-amino-3-(6-(3-hydroxyoxetan-3-yl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(1-hydroxycyclopentyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
((1R,3s,5S)-3-(7-amino-3-(4-(1-hydroxyethyl)phenyl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(1,2-dihydroxyethyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
((1R,3s,5S)-3-(7-amino-3-(8-hydroxy-5,6,7,8-tetrahydroquinolin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(8-hydroxy-5,6,7,8-tetrahydroquinolin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(8-hydroxy-8-methyl-5,6,7,8-tetrahydroquinolin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
Deuterated-(3-exo)-3-[7-amino-6-cyclopropy-3-(5,6,7,8-tetrahydro-8-hydroxy-3-quinolinyl-(D))pyrazolo[1,5-a]pyrimidin-5-yl]-8-(4H-1,2,4-triazol-3-ylcarbonyl)-8-azabicyclo[3.2.1]octane;
Deuterated-(3-exo)-3-[6-acetyl-7-amino-3-(5,6,7,8-tetrhydro-8-hydroxy-3-quinolinyl-(D))pyrazolo[1,5-a]pyrimidin-5-yl]-8-(4H-1,2,4-triazol-3-ylcarbonyl)-8-azabicyclo[3.2.1]octane;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(8-hydroxy-5,6,7,8-tetrahydroquinolin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(8-hydroxy-5,6,7,8-tetrahydroquinolin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
((1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(4-hydroxy-3,4-dihydro-2H-pyrano[3,2-b]pyridin-7-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
((1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(4-hydroxy-3,4-dihydro-2H-pyrano[3,2-b]pyridin-7-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(2,2,2-trifluoro-1-hydroxyethyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(1H-pyrazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(2,2,2-trifluoro-1-hydroxyethyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(6-(2,2,2-trifluoro-1-hydroxyethyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-(2,2,2-trifluoro-1-hydroxyethyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-(2,2,2-trifluoro-1-hydroxyethyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(1H-pyrazol-3-yl)methanone;
1-((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-(2,2,2-trifluoro-1-hydroxyethyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
((1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(6-(1-hydroxycyclobutyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(5-methyl-4H-1,2,4-triazol-3-yl)methanone;
1-((1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(6-(1-hydroxycyclobutyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-((R)-2,2,2-trifluoro-1-hydroxyethyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-((S)-2,2,2-trifluoro-1-hydroxyethyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-(7-amino-3-(6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)pyridin-3-yl)-5-((1R,3s,5S)-8-(5-methyl-4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(7-amino-5-((1R,3s,5S)-8-(5-amino-4H-1,2,4-thiazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-3-(6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(7-amino-5-((1R,3s,5S)-8-(3-amino-1H-pyrazole-5-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-3-(6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-thiazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(2-amino-1,1,1,3,3,3-hexafluoropropan-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(6-(2-amino-1,1,1,3,3,3-hexafluoropropan-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-(7-amino-3-(6-(2-amino-1,1,1,3,3,3-hexafluoropropan-2-yl)pyridin-3-yl)-5-((1R,3s,5S)-8-(5-methyl-4H-1,2,4-thiazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-(7-amino-3-(6-(2-amino-1,1,1,3,3,3-hexafluoropropan-2-yl)pyridin-3-yl)-5-((1R,3s,5S)-8-(3-amino-1H-pyrazole-5-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
((1R,3s,5S)-3-(7-amino-3-(6-(2-amino-1,1,1,3,3,3-hexafluoropropan-2-yl)pyridin-3-yl)-6-cyclopropylpyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
1-((1R,3s,5S)-3-(7-amino-3-(6-(2-amino-1,1,1,3,3,3-hexafluoropropan-2-yl)pyridin-3-yl)-6-cyclopropylpyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
((1R,3s,5S)-3-(7-amino-3-(6-(2-amino-1,1,1,3,3,3-hexafluoropropan-2-yl)pyridin-3-yl)-6-cyclopropylpyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(5-methyl-4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-(2-amino-1,1,1,3,3,3-hexafluoropropan-2-yl)pyridin-3-yl)-6-cyclopropylpyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(5-amino-4H-1,2,4-triazol-3-yl)methanone;
(3-amino-1H-pyrazol-5-yl)((1R,3s,5S)-3-(7-amino-3-(6-(2-amino-1,1,1,3,3,3-hexafluoropropan-2-yl)pyridin-3-yl)-6-cyclopropylpyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)methanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(2-(hydroxymethyl)thiazol-5-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
((1R,3s,5S)-3-(7-amino-3-(2-(hydroxymethyl)thiazol-5-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
(5-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-3-yl)thiazol-2-yl)methyl 4H-1,2,4-triazole-3-carboxylate;
((1R,3s,5S)-3-(7-amino-3-(2-(aminomethyl)thiazol-5-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
N-((5-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-3-yl)thiazol-2-yl)methyl)-4H-1,2,4-triazole-3-carboxamide;
((1R,3s,5S)-3-(7-amino-3-(2-(aminomethyl)thiazol-5-yl)-6-cyclopropylpyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(2-(aminomethyl)-4-cyclopropylthiazol-5-yl)-6-cyclopropylpyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
1-(5-((1R,3s,5S)-8-(1H-1,2,4-triazole-5-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(5-fluoro-6-(2-hydroxypropan-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-(8-(4H-1,2,4-triazole-3-carbonyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
(2R)-1-(3-(6-acetyl-7-amino-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)-2-hydroxypropan-1-one;
1-(5-(5-(4H-1,2,4-triazole-3-carbonyl)-2,5-diazabicyclo[2.2.2]octan-2-yl)-7-amino-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
(2R)-1-(5-(6-acetyl-7-amino-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-2,5-diazabicyclo[2.2.2]octan-2-yl)-2-hydroxypropan-1-one;
1-(5-(3-(4H-1,2,4-triazole-3-carbonyl)-3,8-diazabicyclo[3.2.1]octan-8-yl)-7-amino-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
(2R)-1-(8-(6-acetyl-7-amino-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-3,8-diazabicyclo[3.2.1]octan-3-yl)-2-hydroxypropan-1-one;
1-(8-(6-acetyl-7-amino-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-3,8-diazabicyclo[3.2.1]octan-3-yl)-2-hydroxyethanone;
N-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-6-cyclopropyl-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-7-yl)acetamide;
N-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-6-acetyl-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-7-yl)acetamide;
N-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-7-yl)acetamide;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(pyrrolidin-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(6-(pyrrolidin-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-(pyrrolidin-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
1-((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-(pyrrolidin-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
((1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(6-(pyrrolidin-2-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
(R)-4-(5-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-6-acetyl-7-aminopyrazolo[1,5-a]pyrimidin-3-yl)pyridin-2-yl)oxazolidin-2-one;
(S)-4-(5-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-6-acetyl-7-aminopyrazolo[1,5-a]pyrimidin-3-yl)pyridin-2-yl)oxazolidin-2-one;
(S)-4-(5-(6-acetyl-7-amino-5-((1R,3s,5S)-8-(2-hydroxyacetyl)-8-azabicyclo[3.2.1]octan-3-yl)pyrazolo[1,5-a]pyrimidin-3-yl)pyridin-2-yl)oxazolidin-2-one;
2-(5-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-6-acetyl-7-aminopyrazolo[1,5-a]pyrimidin-3-yl)pyridin-2-yl)pyrazolidin-3-one;
2-(5-(6-acetyl-7-amino-5-((1R,3s,5S)-8-(2-hydroxyacetyl)-8-azabicyclo[3.2.1]octan-3-yl)pyrazolo[1,5-a]pyrimidin-3-yl)pyridin-2-yl)pyrazolidin-3-one;
1-(7-amino-5-((1R,3r,5S)-3-hydroxy-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
((1R,3r,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-3-hydroxy-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3r,5S)-3-(7-amino-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-3-hydroxy-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3r,5S)-3-(7-amino-6-cyclopropyl-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-3-hydroxy-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-3-hydroxy-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
1-(5-(9-(1H-1,2,4-triazole-3-carbonyl)-3-oxa-9-azabicyclo[3.3.1]nonan-7-yl)-7-amino-3-(1-phenyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-(9-(1H-1,2,4-triazole-3-carbonyl)-3-oxa-9-azabicyclo[3.3.1]nonan-7-yl)-7-amino-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(7-(6-acetyl-7-amino-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-3-oxa-9-azabicyclo[3.3.1]nonan-9-yl)-2-hydroxyethanone;
(7-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-3-oxa-9-azabicyclo[3.3.1]nonan-9-yl)(1H-1,2,4-triazol-3-yl)methanone;
(mixture of stereoisomer);
(7-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-3-oxa-9-azabicyclo[3.3.1]nonan-9-yl)(1H-1,2,4-triazol-3-yl)methanone;
(isomer I);
(7-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-3-oxa-9-azabicyclo[3.3.1]nonan-9-yl)(1H-1,2,4-triazol-3-yl)methanone;
(isomer II);
(7-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-3-oxa-9-azabicyclo[3.3.1]nonan-9-yl)(1-hydroxycyclopropyl)methanone;
(isomer II);
1-(5-(9-(1H-1,2,4-triazole-3-carbonyl)-9-azabicyclo[3.3.1]nonan-3-yl)-7-amino-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(7-amino-5-((1S,3R,5R)-6-hydroxy-8-(1H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-((1S,3R,5R)-3-(6-acetyl-7-amino-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-6-hydroxy-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
1-(5-(7-(1H-1,2,4-triazole-3-carbonyl)-7-azabicyclo[2.2.1]heptan-2-yl)-7-amino-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
((1R,3s,5S)-7-(7-amino-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-3,9-diazabicyclo[3.3.1]nonan-9-yl)(1H-1,2,4-triazol-3-yl)methanone;
endo/exo-7-[6-acetyl-7-amino-3-(6-phenyl-3-pyridinyl)pyrazolo[1,5-a]pyrimidin-5-yl]-9-(4h-1,2,4-triazol-3-ylcarbonyl)-3-thia-9-azabicyclo[3.3.1]nonane, 3,3-dioxide;
((1R,3s,5S)-3-(7-amino-6-(1-hydroxycyclopropyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(1H-1,2,4-triazol-3-yl)methanone;
5-((1R,3s,5S)-8-(1H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidine-6-carboxamide;
((1R,3s,5S)-3-(7-(methylamino)-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(3-fluoro-4-(hydroxymethyl)phenyl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
1-((1R,3s,5S)-3-(7-amino-3-(3-fluoro-4-(hydroxymethyl)phenyl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
((1R,3s,5S)-3-(7-amino-3-(4-(1-aminocyclopropyl)-3-fluorophenyl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(4-(2-aminopropan-2-yl)-3-fluorophenyl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
(E)-4-((1R,3s,5S)-3-(7-amino-3-(6-(2-fluorophenyl)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octane-8-carbonyl)-N′-(3-(dimethylamino)propyl)-N-ethyl-2H-1,2,3-triazole-2-carboximidamide;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(cyclopropylamino)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-aminopyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(2-(cyclopropylamino)pyrimidin-5-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(6-(cyclopropylamino)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
N′-(5-(6-acetyl-7-amino-5-((1R,3s,5S)-8-(2-hydroxyacetyl)-8-azabicyclo[3.2.1]octan-3-yl)pyrazolo[1,5-a]pyrimidin-3-yl)pyridin-2-yl)acetohydrazide;
N′-(5-(6-acetyl-7-amino-5-((1R,3s,5S)-8-(2-hydroxyacetyl)-8-azabicyclo[3.2.1]octan-3-yl)pyrazolo[1,5-a]pyrimidin-3-yl)pyridin-2-yl)propionohydrazide;
((1R,3s,5S)-3-(7-amino-3-(6-cyclobutoxypyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-3-(6-(cyclopropylmethoxy)pyridin-3-yl)-6-(methylsulfonyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
((1R,3r,5S)-3-(7-amino-6-cyclopropyl-3-(2H-pyrazolo[4,3-h]pyrano[3,2-b]pyridin-7-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(3-hydroxyprop-1-ynyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(3-methoxyprop-1-ynyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(3-(2-hydroxyethoxy)prop-1-ynyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(3-(2-methoxyethoxyl)prop-1-ynyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(cyclopropylethynyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
1-((1R,3s,5S)-3-(6-acetyl-7-amino-3-(6-(cyclopropylethynyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxyethanone;
((1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(pyridin-3-ylethynyl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
5-((1R,3s,5S)-8-(4-aminopyrimidin-2-yl)-8-azabicyclo[3.2.1]octan-3-yl)-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine;
5-((1R,3s,5S)-8-(5-aminopyrimidin-4-yl)-8-azabicyclo[3.2.1]octan-3-yl)-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine;
5-((1R,3s,5S)-8-(3-aminopyridin-2-yl)-8-azabicyclo[3.2.1]octan-3-yl)-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine;
N-(4-((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)pyrimidin-5-yl)acetamide;
N-(2-((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)pyridin-3-yl)acetamide;
5-(5-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-6-acetyl-7-aminopyrazolo[1,5-a]pyrimidin-3-yl)pyridin-2-yl)-5-methylimidazolidine-2,4-dione;
5-(5-(6-acetyl-7-amino-5-((1R,3s,5S)-8-(2-hydroxyacetyl)-8-azabicyclo[3.2.1]octan-3-yl)pyrazolo[1,5-a]pyrimidin-3-yl)pyridin-2-yl)-5-methylimidazolidine-2,4-dione;
(1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octane-8-carbonitrile;
(1R,3s,5S)-3-(6-acetyl-7-amino-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octane-8-carbonitrile;
(1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-N-hydroxy-8-azabicyclo[3.2.1]octane-8-carboximidamide;
(1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octane-8-carboximidamide;
3-((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)-1,2,4-oxadiazol-5(4H)-one;
1-(5-(5-((1R,3s,5S)-8-(1H-1,2,4-triazole-5-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-6-acetyl-7-aminopyrazolo[1,5-a]pyrimidin-3-yl)pyridin-2-yl)-3-methylurea;
N-(5-(5-((1R,3s,5S)-8-(1H-1,2,4-triazole-5-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-6-acetyl-7-aminopyrazolo[1,5-a]pyrimidin-3-yl)pyridin-2-yl)acetamide;
ethyl 5-(6-acetyl-7-amino-5-((1R,3s,5S)-8-(2-hydroxyacetyl)-8-azabicyclo[3.2.1]octan-3-yl)pyrazolo[1,5-a]pyrimidin-3-yl)pyridin-2-ylcarbamate;
ethyl 5-(5-((1R,3s,5S)-8-(1H-1,2,4-triazole-5-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-6-acetyl-7-aminopyrazolo[1,5-a]pyrimidin-3-yl)pyridin-2-ylcarbamate;
1-(4-(7-amino-5-((1R,3s,5S)-8-azabicyclo[3.2.1]octan-3-yl)pyrazolo[1,5-a]pyrimidin-3-yl)phenyl)-3-methylurea;
1-(4-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-aminopyrazolo[1,5-a]pyrimidin-3-yl)phenyl)-3-methylurea;
1-(4-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-aminopyrazolo[1,5-a]pyrimidin-3-yl)-2-methoxyphenyl)-3-ethylurea;
1-(4-(7-amino-5-((1R,3s,5S)-8-(2-hydroxyacetyl)-8-azabicyclo[3.2.1]octan-3-yl)pyrazolo[1,5-a]pyrimidin-3-yl)phenyl)-3-methylurea;
1-(4-(7-amino-5-((1R,3s,5S)-8-(morpholine-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)pyrazolo[1,5-a]pyrimidin-3-yl)phenyl)-3-methylurea;
1-(5-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-aminopyrazolo[1,5-a]pyrimidin-3-yl)pyridin-2-yl)-3-ethylurea;
1-(4-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-6-acetyl-7-aminopyrazolo[1,5-a]pyrimidin-3-yl)phenyl)-3-methylurea;
(1R,3s,5S,E)-3-(7-amino-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-N′-cyano-8-azabicyclo[3.2.1]octane-8-carboximidamide;
(1R,3s,5S,E)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-N′-cyano-8-azabicyclo[3.2.1]octane-8-carboximidamide;
((1R,3s,5S)-3-(7-amino-3-(2-aminopyrimidin-5-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)-5-((1R,3s,5S)-8-(2,2,2-trifluoroethyl)-8-azabicyclo[3.2.1]octan-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine;
1-(4-(7-amino-5-((1R,3s,5S)-8-(2,2,2-trifluoroethyl)-8-azabicyclo[3.2.1]octan-3-yl)pyrazolo[1,5-a]pyrimidin-3-yl)phenyl)-3-methylurea;
5-((1R,3s,5S)-8-((4H-1,2,4-triazol-3-yl)methyl)-8-azabicyclo[3.2.1]octan-3-yl)-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine;
2-((1R,3s,5S)-3-(7-amino-6-(methylsulfonyl)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)acetamide;
1-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(1-amino-2,2,2-trifluoroethyl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)ethanone;
((1R,3s,5S)-3-(7-amino-3-(2-(aminomethyl)pyrimidin-5-yl)-6-bromopyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-1,2,4-triazol-3-yl)methanone;
5-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-aminopyrazolo[1,5-a]pyrimidin-3-yl)pyrimidine-2-carbonitrile;
5-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-6-cyclopropylpyrazolo[1,5-a]pyrimidin-3-yl)pyrimidine-2-carbonitrile;
5-(5-((1R,3s,5S)-8-(4H-1,2,4-triazole-3-carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-6-acetyl-7-aminopyrazolo[1,5-a]pyrimidin-3-yl)pyrimidine-2-carboxamide;
((1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(5-(piperazin-1-yl)-4H-1,2,4-triazol-3-yl)methanone;
((1R,3S,5S)-3-(7-amino-6-cyclopropyl-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(5-((R)-3-hydroxypyrrolidin-1-yl)-4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(5-(2-methoxyethoxy)-4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(5-methoxy-4-methyl-4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(5-(4-methylpiperazin-1-yl)-4H-1,2,4-triazol-3-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(5-methoxy-4H-1,2,4-triazol-3-yl)methanone;
(5-amino-4H-1,2,4-triazol-3-yl)((1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(6-phenylpyridin-3-yl)pyrazolo[1, 5-a]pyrimidin-5-yl)-8-azabicyclo[3 0.2.1]octan-8-yl)methanone;
((1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(5-morpholino-4H-1,2,4-triazol-3-yl)methanone; and
((1R,3s,5S)-3-(7-amino-6-cyclopropyl-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(5-hydroxy-4H-1,2,4-triazol-3-yl)methanone;
or a stereoisomer thereof;
or a pharmaceutically acceptable salt thereof;
or a pharmaceutically acceptable salt of the stereoisomer thereof.
11. A compound that is 1-[(3-Exo)-3-{7-amino-6-fluoro-3-[6-(1H-imidazol-2-yl)pyridin-3-yl]pyrazolo[1,5-a]pyrimidin-5-yl}-8-azabicyclo[3.2.1]oct-8-yl]-2-hydroxyethanone
or a stereoisomer thereof;
or a pharmaceutically acceptable salt thereof;
or pharmaceutically acceptable salt of the stereoisomer thereof.
12. A pharmaceutical composition comprising the compound of claim 1 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
13. A method of treating prostate tumor, solid tumors, lymphoma, multiple myeloma, macroglobulinemia, glioma and breast cancer by the inhibition of mTor, comprising administering a therapeutically effective amount of the compound of claim 1 or a pharmaceutically acceptable salt thereof to a patient in need thereof.