Modified saponins for the treatment of fungal infections
Methods of treating a fungal infection in a subject, the method comprising administering to the subject a modified saponin.
1. A method of treating a fungal infection in a subject, the method comprising administering to the subject a therapeutically effective amount of a compound of Formula I:
or a pharmaceutically acceptable salt thereof, wherein:
R 1 is H or OH;
R 2 is OH;
Gly is
R 3 is OH or
R 4 and R 5 are each independently OH or
and
denotes a single bond.
2. The method of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
3. The method of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
4. The method of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
5. A method of treating a fungal infection in a subject, the method comprising administering to the subject a therapeutically effective amount of a compound of Formula I:
or a pharmaceutically acceptable salt thereof, wherein:
R 1 and R 2 are each independently H or OH;
Gly is
R 3 is OH or
R 4 and R 5 are each independently OH or
and
denotes a double bond.
6. The method of claim 5 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
7. The method of claim 1 , wherein the fungal infection is infection with a Candida species fungus.
8. The method of claim 7 , wherein the Candida species is C. albicans.
9. The method of claim 5 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
10. The method of claim 5 , wherein the fungal infection is infection with a Candida species fungus.
11. The method of claim 5 , wherein the Candida species is C. albicans.