Replenishment and enrichment of ocular surface lubrication
An ophthalmic composition, and methods of use thereof, including for treating ocular boundary deficiency, symptoms associated therewith, or undesired condition that is associated with or causes ocular boundary deficiency at the ocular surface or for the treatment or care of ophthalmic devices. The ophthalmic composition comprises a human PRG4 protein, a lubricant fragment, homolog, or isoform thereof, suspended in an ophthalmically acceptable balanced salt solution. The ophthalmic composition may also comprise one or more ophthalmically acceptable agents.
1. A composition for the care of an ophthalmic contact lens, the composition comprising PRG4 disposed in an ophthalmically acceptable balanced salt solution and a contact lens care agent comprising a surfactant, a protease, a disinfectant, or a combination thereof.
2. The composition of claim 1 , comprising one or more surfactants.
3. The composition of claim 1 , further comprising one or more viscosity increasing components.
4. The composition of claim 1 , further comprising one or more chelating components.
5. The composition of claim 1 , comprising one or more proteases.
6. The composition of claim 1 , comprising one or more disinfectants.
7. The composition of claim 1 , comprising a PRG4 at a concentration of 10-10,000 μg/ml.
8. The composition of claim 1 , further comprising an effective concentration of sodium hyaluronate or hyaluronic acid.
9. The composition of claim 8 , comprising sodium hyaluronate or hyaluronic acid at a concentration of 10-100,000 μg/ml.
10. The composition of claim 9 , comprising sodium hyaluronate or hyaluronic acid at a concentration of 500-5,000 μg/ml.
11. The composition of claim 1 , comprising a concentration of surface active phospholipid selected from the group consisting of L-α-dipalmitoylphosphatidylcholine, phosphatidylcholine, phosphatidylethanolamine and sphingomyelin.
12. The composition of claim 11 , wherein the surface active phospholipid is present at a concentration of 10-10,000 μg/ml.
13. The composition of claim 1 , wherein the ophthalmically acceptable balanced salt solution comprises at least three different electrolytes selected from the group consisting of sodium phosphate, sodium chloride, potassium chloride, sodium bicarbonate, potassium bicarbonate, calcium chloride, magnesium chloride, sodium acetate, sodium citrate, hydrochloric acid, and sodium hydroxide.
14. The composition of claim 1 , wherein the PRG4 has an average molar mass of between 50 kDa and 400 kDa.
15. The composition of claim 14 , wherein the PRG4 comprises a lubricating fragment, multimer or a homolog thereof.
16. The composition of claim 14 , wherein the PRG4 is a recombinant PRG4 protein, or functional fragment thereof.
17. The composition of claim 14 , wherein the PRG4 is a purified naturally occurring PRG4 protein.