Natural product analogs including an anti-inflammatory cyanoenone pharmacore and methods of use
This invention provides novel compounds comprising the following anti-inflammatory pharmacore: wherein X, R 1 and R 2 are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.
1. A compound of the formula:
wherein:
R 3 and R 4 are each independently:
hydrogen, hydroxy, halo, amino, hydroxyamino, nitro, cyano, azido, or mercapto; or
alkyl (C≦12) , alkenyl (C≦12) , alkynyl (C≦12) , aryl (C≦12) , aralkyl (C≦12) , heteroaryl (C≦12) , heteroaralkyl (C≦12) , acyl (C≦12) , alkoxy (C≦12) , alkenyloxy (C≦12) , alkynyloxy (C≦12) , aryloxy (C≦12) , aralkoxy (C≦12) , heteroaryloxy (C≦12) , heteroaralkoxy (C≦12) , acyloxy (C≦12) , alkylamino (C≦12) , dialkylamino (C≦12) , alkoxyamino (C≦12) , alkenylamino (C≦12) , alkynylamino (C≦12) , arylamino (C≦12) , aralkylamino (C≦12) , heteroarylamino (C≦12) , heteroaralkylamino (C≦12) , amido (C≦12) , alkylsulfonylamino (C≦12) , alkylsilyl (C≦12) , alkylsilyloxy (C≦12) , or a substituted version of any of these groups;
or a pharmaceutically acceptable salt, tautomer, acetal, or ketal, thereof.
2. The compound of claim 1 , further defined by the formula:
or a pharmaceutically acceptable salt, ketal, or tautomer thereof.
3. The compound of claim 1 , further selected from the group consisting of:
or a pharmaceutically acceptable salt, ketal, or tautomer thereof.