Compounds and methods for delivery of prostacyclin analogs
This invention pertains generally to prostacyclin analogs and methods for their use in promoting vasodilation, inhibiting platelet aggregation and thrombus formation, stimulating thrombolysis, inhibiting cell proliferation (including vascular remodeling), providing cytoprotection, preventing atherogenesis and inducing angiogenesis. Generally, the compounds and methods of the present invention increase the oral bioavailability and circulating concentrations of treprostinil when administered orally. Compounds of the present invention have the following formula:
1. A polymorph of a diethanolamine salt of treprostinil that melts at 103° C.
2. A pharmaceutical composition comprising (a) a polymorph of a diethanolamine salt of treprostinil that melts at 103° C. and (b) a pharmaceutically acceptable carrier.
3. The pharmaceutical composition according to claim 2 ,
wherein the formulation exists in a dosage form selected from a capsule, tablet, liquid, or suspension.
4. The polymorph of claim 1 , which has an X-ray powder diffraction spectrum as shown in FIG. 15 .
5. A method of treating pulmonary hypertension comprising administering to a subject suffering from pulmonary hypertension a pharmaceutical composition as claimed in claim 2 .