Sericin extracted fabrics
Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.
1. A method for generating soft-tissue in the body of an individual, comprising implanting a fabric having one or more biomechanical properties of soft tissue into the body of the individual, wherein the fabric comprises one or more individual yarns comprised of sericin-extracted native fibroin fibers.