Composition comprising an angiopoietin-4 fragment
The present invention relates to Angiopoietin-3 (Ang-3) and Angiopoietin-4 (Ang-4). The present invention also relates to methods of modulating an activity of Ang-3 or Ang-4. The present invention further relates to methods of treating cancer, diabetes, and arthritis.
1. A polypeptide comprising a signal peptide linked to an Angiopoietin-4 (Ang-4) fragment; wherein:
the Angiopoietin-4 fragment comprises Angiopoietin-4 fibrinogen homology domain;
the Angiopoietin-4 fragment is free of Angiopoietin-4 coiled-coiled domain;
the Angiopoietin-4 fragment is effective to treat cancer; and
Angiopoietin-4 is encoded by SEQ ID NO:3.
2. The polypeptide of claim 1 , wherein the signal peptide is an Angiopoietin-4 signal peptide.
3. The polypeptide of claim 2 , wherein the polypeptide further comprises an Angiopoietin-4 linker domain.
4. The polypeptide of claim 3 , wherein the polypeptide consists of the Angiopoietin-4 signal peptide, the Angiopoietin-4 linker domain and the Angiopoietin-4 fibrinogen homology domain.