Pyridyl piperidine orexin receptor antagonists

1. A compound of the formula Ic:

wherein:

R 1a , R 1b and R 1c are independently selected from the group consisting of:

(1) hydrogen,

(2) halogen,

(3) —(C═O) m —O n —C 1-6 alkyl, where m is 0 or 1, n is 0 or 1 (wherein if m is 0 or n is 0, a bond is present) and where the alkyl is unsubstituted or substituted with one or more substituents selected from R 13 ,

(4) —(C═O) m —O n —C 3-6 cycloalkyl, where the cycloalkyl is unsubstituted or substituted with one or more substituents selected from R 13 ,

(5) —(C═O) m —C 2-4 alkenyl, where the alkenyl is unsubstituted or substituted with one or more substituents selected from R 13 ,

(6) —(C═O) m —C 2-4 alkynyl, where the alkynyl is unsubstituted or substituted with one or more substituents selected from R 13 ,

(7) —(C═O) m —O n -phenyl or —(C═O) m —O n -napthyl, where the phenyl or napthyl is unsubstituted or substituted with one or more substituents selected from R 13 ,

(8) —(C═O) m —O n -heterocycle, where the heterocycle is unsubstituted or substituted with one or more substituents selected from R 13 ,

(9) —(C═O) m —NR 10 R 11 , wherein R 10 and R 11 are independently selected from the group consisting of:

(a) hydrogen,

(b) C 1-6 alkyl, which is unsubstituted or substituted with R 13 ,

(c) C 3-6 alkenyl, which is unsubstituted or substituted with R 13 ,

(d) C 3-6 alkynyl, which is unsubstituted or substituted with R 13 ,

(e) C 3-6 cycloalkyl which is unsubstituted or substituted with R 13 ,

(f) phenyl, which is unsubstituted or substituted with R 13 , and

(g) heterocycle, which is unsubstituted or substituted with R 13 ,

(10) —S(O) 2 —NR 10 R 11 ,

(11) —S(O) q R 12 , where q is 0, 1 or 2 and where R 12 is selected from the definitions of R 10 and R 11 ,

(12) —CO 2 H,

(13) —CN, and

(14) —NO 2 ;

R 2a , R 2b and R 2c are independently selected from the group consisting of:

(1) hydrogen,

(2) halogen,

(3) hydroxyl,

(4) —(C═O) m —O n —C 1-6 alkyl, where the alkyl is unsubstituted or substituted with one or more substituents selected from R 13 ,

(5) —(C═O) m —O n —C 3-6 cycloalkyl, where the cycloalkyl is unsubstituted or substituted with one or more substituents selected from R 13 ,

(6) —(C═O) m —C 2-4 alkenyl, where the alkenyl is unsubstituted or substituted with one or more substituents selected from R 13 ,

(7) —(C═O) m —C 2-4 alkynyl, where the alkynyl is unsubstituted or substituted with one or more substituents selected from R 13 ,

(8) —(C═O) m —O n -phenyl or —(C═O) m —O n -napthyl, where the phenyl or napthyl is unsubstituted or substituted with one or more substituents selected from R 13 ,

(9) —(C═O) m —O n -heterocycle, where the heterocycle is unsubstituted or substituted with one or more substituents selected from R 13 ,

(10) —(C═O) m —NR 10 R 11 ,

(11) —S(O) 2 —NR 10 R 11 ,

(12) —S(O) q —R 12 ,

(13) —CO 2 H,

(14) —CN, and

(15) —NO 2 ;

R 3 is C 1-6 alkyl or C 3-6 cycloalkyl, which is unsubstituted or substituted with one or more substituents selected from R 13 ;

R 13 is selected from the group consisting of:

(1) halogen,

(2) hydroxyl,

(3) —(C═O) m —O n —C 1-6 alkyl, where the alkyl is unsubstituted or substituted with one or more substituents selected from R 14 ,

(4) —O n —(C 1-3 )perfluoroalkyl,

(5) —(C═O) m —O n —C 3-6 cycloalkyl, where the cycloalkyl is unsubstituted or substituted with one or more substituents selected from R 14 ,

(6) —(C═O) m —C 2-4 alkenyl, where the alkenyl is unsubstituted or substituted with one or more substituents selected from R 14 ,

(7) —(C═O) m —C 2-4 alkynyl, where the alkynyl is unsubstituted or substituted with one or more substituents selected from R 14 ,

(8) —(C═O) m —O n -phenyl or —(C═O) m —O n -napthyl, where the phenyl or napthyl is unsubstituted or substituted with one or more substituents selected from R 14 ,

(9) —(C═O) m —O n -heterocycle, where the heterocycle is unsubstituted or substituted with one or more substituents selected from R 14 ,

(10) —(C═O) m —NR 10 R 11 ,

(11) —S(O) 2 —NR 10 R 11 ,

(12) —S(O) q —R 12 ,

(13) —CO 2 H,

(14) —CN, and

(15) —NO 2 ;

R 14 is selected from the group consisting of:

(1) hydroxyl,

(2) halogen,

(3) C 1-6 alkyl,

(4) —C 3-6 cycloalkyl,

(5) —O—C 1-6 alkyl,

(6) —O(C═O)—C 1-6 alkyl,

(7) —NH—C 1-6 alkyl,

(8) phenyl,

(9) heterocycle,

(10) —CO 2 H, and

(11) —CN;

or a pharmaceutically acceptable salt thereof.

2. The compound of claim 1 wherein R 1a , R 1b and R 1c are independently selected from the group consisting of:

(1) hydrogen,

(2) halogen,

(3) C 1-6 alkyl, which is unsubstituted or substituted with halogen, hydroxyl, phenyl or napthyl,

(4) —O—C 1-6 alkyl, which is unsubstituted or substituted with halogen, hydroxyl or phenyl,

(5) heteroaryl, wherein heteroaryl is selected from triazolyl, oxazolyl, pyrrolyl, imidazolyl, indolyl, pyridyl, and pyrimidinyl, which is unsubstituted or substituted with halogen, hydroxyl, C 1-6 alkyl, —O—C 1-6 alkyl or —NO 2 ,

(6) phenyl, which is unsubstituted or substituted with halogen, hydroxyl, C 1-6 alkyl, —O—C 1-6 alkyl or —NO 2 ,

(7) —O-phenyl, which is unsubstituted or substituted with halogen, hydroxyl, C 1-6 alkyl, —O—C 1-6 alkyl or —NO 2 , and

(8) —NH—C 1-6 alkyl, or —N(C 1-6 alkyl)(C 1-6 alkyl), which is unsubstituted or substituted with halogen, hydroxyl, C 1-6 alkyl, —O—C 1-6 alkyl or —NO 2 .

3. The compound of claim 2 wherein R 1a , R 1b and R 1c are independently selected from the group consisting of:

(1) hydrogen,

(2) halogen,

(3) C 1-6 alkyl, which is unsubstituted or substituted with halogen, hydroxyl or phenyl or napthyl,

(4) —O—C 1-6 alkyl, which is unsubstituted or substituted with halogen, hydroxyl or phenyl,

(5) heteroaryl, wherein heteroaryl is selected from triazolyl, oxazolyl and pyrimidinyl, which is unsubstituted or substituted with halogen, hydroxyl or C 1-6 alkyl, and

(6) phenyl, which is unsubstituted or substituted with halogen, hydroxyl or C 1-6 alkyl.

4. The compound of claim 1 wherein R 1a , R 1b and R 1c are independently selected from the group consisting of:

(1) hydrogen,

(2) chloro,

(3) fluororo,

(4) methyl,

(5) triazolyl,

(6) oxazolyl,

(7) pyrimidinyl, and

(8) phenyl.

5. The compound of claim 1 wherein R 2a , R 2b and R 2c are independently selected from the group consisting of:

(1) hydrogen,

(2) halogen,

(3) hydroxyl,

(4) C 1-6 alkyl, which is unsubstituted or substituted with halogen, hydroxyl or phenyl or napthyl,

(5) —O—C 1-6 alkyl, which is unsubstituted or substituted with halogen, hydroxyl or phenyl,

(6) heteroaryl, wherein heteroaryl is selected from pyrrolyl, imidazolyl, indolyl, pyridyl, and pyrimidinyl, which is unsubstituted or substituted with halogen, hydroxyl, C 1-6 alkyl, —O—C 1-6 alkyl or —NO 2 ,

(7) phenyl, which is unsubstituted or substituted with halogen, hydroxyl, C 1-6 alkyl, —O—C 1-6 alkyl or —NO 2 ,

(8) —O-phenyl, which is unsubstituted or substituted with halogen, hydroxyl, C 1-6 alkyl, —O—C 1-6 alkyl or —NO 2 , and

(9) —NH—C 1-6 alkyl, or —N(C 1-6 alkyl)(C 1-6 alkyl), which is unsubstituted or substituted with halogen, hydroxyl, C 1-6 alkyl, —O—C 1-6 alkyl or —NO 2 .

6. The compound of claim 5 wherein R 2a , R 2b and R 2c are independently selected from the group consisting of:

(1) hydrogen,

(2) halogen,

(3) C 1-6 alkyl, which is unsubstituted or substituted with halogen,

(4) —O—C 1-6 alkyl, which is unsubstituted or substituted with halogen, and

(5) —NH—C 1-6 alkyl, or —N(C 1-6 alkyl)(C 1-6 alkyl), which is unsubstituted or substituted with halogen.

7. The compound of claim 6 wherein R 2a , R 2b and R 2c are independently selected from the group consisting of:

(1) hydrogen,

(2) chloro,

(3) fluoro,

(4) bromo,

(5) methoxy,

(6) t-butoxy,

(7) difluoromethyl, and

(8) trifluoromethyl.

8. The compound of claim 7 wherein R 2a , R 2b and R 2c are independently selected from the group consisting of:

(1) hydrogen,

(2) fluoro, and

(3) trifluoromethyl.

9. The compound of claim 1 wherein R 3 is methyl or ethyl.

10. The compound of claim 9 wherein R 3 is methyl.

11. A compound which is selected from the group consisting of:

5-fluoro-2-({6-methyl-1-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]piperidin-3-yl }methoxy)pyridine;

5-fluoro-2-({(3R,6R)-6-methyl-1-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]piperidin-3-yl}methoxy)pyridine;

5-fluoro-2-({(3S,6S)-6-methyl-1-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]piperidin-3-yl}methoxy)pyridine;

5-fluoro-2-({(3R,6S)-6-methyl-1-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]piperidin-3-yl}methoxy)pyridine;

5-fluoro-2-({(3S,6R)-6-methyl-1-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]piperidin-3-yl}methoxy)pyridine;

2-{2-[(5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl)carbonyl]-4-methylphenyl}pyrazine;

2-{2-[((2R,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl)carbonyl]-4-methylphenyl}pyrazine;

2-{2-[((2S,5S)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl)carbonyl]-4-methylphenyl}pyrazine;

2-{2-[(2R,5S)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl)carbonyl]-4-methylphenyl}pyrazine;

2-{2-[((2S,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl)carbonyl]-4-methylphenyl}pyrazine;

2-methyl-6-({6-methyl-1-[2-(2H-1,2,3-triazol-2-yl)benzoyl]piperidin-3-yl}methoxy)pyridine;

2-methyl-6-({(3R,6R)-6-methyl-1-[2-(2H-1,2,3-triazol-2-yl)benzoyl]piperidin-3-yl}methoxy)pyridine;

2-methyl-6-({(3S,6S)-6-methyl-1-[2-(2H-1,2,3-triazol-2-yl)benzoyl]piperidin-3-yl}methoxy)pyridine;

2-methyl-6-({(3R,6S)-6-methyl-1-[2-(2H-1,2,3-triazol-2-yl)benzoyl]piperidin-3-yl}methoxy)pyridine;

2-methyl-6-({(3S,6R)-6-methyl-1-[2-(2H-1,2,3-triazol-2-yl)benzoyl]piperidin-3-yl}methoxy)pyridine;

2-{2-[(2R,5S)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl)carbonyl]-4-methylphenyl}pyrimidine;

2-{2-[((2S,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl)carbonyl]-4-methylphenyl}pyrimidine;

3-[(5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl)carbonyl]-4-(2H-1,2,3-triazol-2-yl)benzoic acid;

3-[((2R,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl)carbonyl]-4-(2H-1,2,3-triazol-2-yl)benzoic acid;

3-[((2S,5S)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl)carbonyl]-4-(2H-1,2,3-triazol-2-yl)benzoic acid;

3-[((2R,5S)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl)carbonyl]-4-(2H-1,2,3-triazol-2-yl)benzoic acid;

3-[((2S,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl)carbonyl]-4-(2H-1,2,3-triazol-2-yl)benzoic acid;

[3-[(5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl)carbonyl]-4-(2H-1,2,3-triazol-2-yl)phenyl]methanol;

[3-[((2R,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl)carbonyl]-4-(2H-1,2,3-triazol-2-yl)phenyl]methanol;

[3-[((2S,5S)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl)carbonyl]-4-(2H-1,2,3-triazol-2-yl)phenyl]methanol;

[3-[((2R,5S)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl)carbonyl]-4-(2H-1,2,3-triazol-2-yl)phenyl]methanol;

[3-[((2S,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl)carbonyl]-4-(2H-1,2,3-triazol-2-yl)phenyl]methanol;

3-[(5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl)carbonyl]-4-pyrimidin-2-ylbenzoic acid;

3-[((2R,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl)carbonyl]-4-pyrimidin-2-ylbenzoic acid;

3-[((2S,5S)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl)carbonyl]-4-pyrimidin-2-ylbenzoic acid;

3-[((2R,5S)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl)carbonyl]-4-pyrimidin-2-ylbenzoic acid;

3-[((2S,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl)carbonyl]-4-pyrimidin-2-ylbenzoic acid;

{3-[(5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl)carbonyl]-4-pyrimidin-2-ylphenyl}methanol;

{3-[((2R,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl)carbonyl]-4-pyrimidin-2-ylphenyl}methanol;

{3-[((2S,5S)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl)carbonyl]-4-pyrimidin-2-ylphenyl}methanol;

{3-[((2R,5S)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl)carbonyl]-4-pyrimidin-2-ylphenyl}methanol;

{3-[((2S,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl)carbonyl]-4-pyrimidin-2-ylphenyl}methanol;

5-fluoro-2-({6-methyl-1-[5-methyl-2-(1,3-thiazol-2-yl)benzoyl]piperidin-3-yl}methoxy)pyridine;

5-fluoro-2-({(3R,6R)-6-methyl-{[5-methyl-2-(1,3-thiazol-2-yl)benzoyl]piperidin-3-yl}methoxy)pyridine;

2-({6-methyl-1-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]piperidin-3-yl}methoxy)-5-(trifluoromethyl) pyridine;

2-({(3R,6R)-6-methyl-1-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]piperidin-3-yl}methoxy)-5-(trifluoromethyl)pyridine;

2-({6-methyl-1-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]piperidin-3-yl}methoxy)pyridine;

2-({(3R,6R)-6-methyl-1-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]piperidin-3-yl}methoxy)pyridine;

5-fluoro-2-({6-methyl-1-[2-(2H-1,2,3-triazol-2-yl)benzoyl]piperidin-3-yl}methoxy)pyridine;

5-fluoro-2-({(3R,6R)-6-methyl-1-[2-(2H-1,2,3-triazol-2-yl)benzoyl]piperidin-3-yl}methoxy)pyridine;

5-fluoro-2-({6-methyl-1-[(2-methyl-5-phenyl-1,3-thiazol-4-yl)carbonyl]piperidin-3-yl}methoxy)pyridine;

5-fluoro-2-({(3R,6R)-6-methyl-1-[(2-methyl-5-phenyl-1,3-thiazol-4-yl)carbonyl]piperidin-3-yl}methoxy)pyridine;

5-fluoro-2-({6-methyl-1-[(1-methyl-4-phenyl-1H-pyrazol-3-yl)carbonyl]piperidin-3-yl}methoxy)pyridine;

5-fluoro-2-({(3R,6R)-6-methyl-1-[(1-methyl-4-phenyl-1H-pyrazol-3-yl)carbonyl]piperidin-3-yl}methoxy)pyridine;

5-fluoro-2-({6-methyl-1-[5-methyl-2-(1,3-oxazol-2-yl)benzoyl]piperidin-3-yl}methoxy)pyridine;

5-fluoro-2-({(3R,6R)-6-methyl-{[5-methyl-2-(1,3-oxazol-2-yl)benzoyl]piperidin-3-yl}methoxy)pyridine;

5-fluoro-2-({1-[5-fluoro-2-(2H-1,2,3-triazol-2-yl)benzoyl]-6-methylpiperidin-3-yl}methoxy)pyridine;

5-fluoro-2-({(3R,6R)-1-[5-fluoro-2-(2H-1,2,3-triazol-2-yl)benzoyl]-6-methylpiperidin-3-yl}methoxy)pyridine;

2-({1-[5-chloro-2-(2H-1,2,3-triazol-2-yl)benzoyl]-6-methylpiperidin-3-yl}methoxy)-5-fluoropyridine;

2-({(3R,6R)-1-[5-chloro-2-(2H-1,2,3-triazol-2-yl)benzoyl]-6-methylpiperidin-3-yl}methoxy)-5-fluoropyridine;

5-fluoro-2-({6-methyl-1-[(4-methylbiphenyl-2-yl)carbonyl]piperidin-3-yl}methoxy)pyridine;

5-fluoro-2-({(3R,6R)-6-methyl-1-[(4-methylbiphenyl-2-yl)carbonyl]piperidin-3-yl}methoxy)pyridine;

5-chloro-2-({(6-methyl-1-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]piperidin-3-yl}methoxy)pyridine;

5-chloro-2-({(3R,6R)-6-methyl-1-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]piperidin-3-yl}methoxy)pyridine;

5-fluoro-4-methyl-2-({6-methyl-1-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]piperidin-3-yl}methoxy)pyridine;

5-fluoro-4-methyl-2-({(3R,6R)-6-methyl-1-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]piperidin-3-yl}methoxy)pyridine;

2-methyl-6-({6-methyl-1-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]piperidin-3-yl}methoxy)pyridine;

2-methyl-6-({(3R,6R)-6-methyl-1-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]piperidin-3-yl}methoxy)pyridine;

5-methyl-2-({6-methyl-1-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]piperidin-3-yl}methoxy)pyridine;

5-methyl-2-({(3R,6R)-6-methyl-1-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]piperidin-3-yl}methoxy)pyridine;

5-fluoro-2-{[6-methyl-1-(5-methyl-2-pyridin-2-ylbenzoyl)piperidin-3-yl]methoxy}pyridine;

5-fluoro-2-{[(3R,6R)-6-methyl-1-(5-methyl-2-pyridin-2-ylbenzoyl)piperidin-3-yl]methoxy}pyridine;

5-fluoro-2-{[6-methyl-1-(5-methyl-2-pyridin-3-ylbenzoyl)piperidin-3-yl]methoxy}pyridine;

5-fluoro-2-{[(3R,6R)-6-methyl-1-(5-methyl-2-pyridin-3-ylbenzoyl)piperidin-3-yl]methoxy}pyridine;

5-fluoro-2-({1-[2-(5-fluoropyridin-2-yl)-5-methylbenzoyl]-6-methylpiperidin-3-yl}methoxy)pyridine;

5-fluoro-2-({(3R,6R)-1-[2-(5-fluoropyridin-2-yl)-5-methylbenzoyl]-6-methylpiperidin-3-yl}methoxy)pyridine;

2-{4-chloro-2-[(5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl)carbonyl]phenyl}pyrimidine;

2-{4-chloro-2-R(2R,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl)carbonyl]phenyl}pyrimidine;

2-{4-fluoro-2-[(5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl)carbonyl]phenyl}pyrimidine;

2-{4-fluoro-2-[(2R,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl)carbonyl]phenyl}pyrimidine;

5-fluoro-2-({6-methyl-1-[5-methyl-2-(1,3-thiazol-4-yl)benzoyl]piperidin-3-yl}methoxy)pyridine;

5-fluoro-2-({(3R,6R)-6-methyl-{[5-methyl-2-(1,3-thiazol-4-yl)benzoyl]piperidin-3-yl}methoxy)pyridine;

5-fluoro-2-({6-methyl-1-[5-methyl-2-(1H-pyrazol-4-yl)benzoyl]piperidin-3-yl}methoxy)pyridine;

5-fluoro-2-({(3R,6R)-6-methyl-1-[5-methyl-2-(1H-pyrazol-4-yl)benzoyl]piperidin-3-yl}methoxy)pyridine;

5-fluoro-2-({(6-methyl-1-[5-methyl-2-(2H-tetrazol-2-yl)benzoyl]piperidin-3-yl}methoxy)pyridine;

5-fluoro-2-({(3R,6R)-6-methyl-1-[5-methyl-2-(2H-tetrazol-2-yl)benzoyl]piperidin-3-yl}methoxy)pyridine;

5-fluoro-2-({6-methyl-1-[5-methyl-2-(1H-pyrazol-1-yl)benzoyl]piperidin-3-yl}methoxy)pyridine;

5-fluoro-2-({(3R,6R)-6-methyl-1-[5-methyl-2-(1H-pyrazol-1-yl)benzoyl]piperidin-3-yl}methoxy)pyridine;

2-{[1-(2-ethoxybenzoyl)-6-methylpiperidin-3-yl]methoxy}-5-fluoropyridine;

2-{[(3R,6R)-1-(2-ethoxybenzoyl)-6-methylpiperidin-3-yl]methoxy}-5-fluoropyridine;

2-{[1-(biphenyl-2-ylcarbonyl)-6-methylpiperidin-3-yl]methoxy}-5-fluoropyridine;

2-{[(3R,6R)-1-(biphenyl-2-ylcarbonyl)-6-methylpiperidin-3-yl]methoxy}-5-fluoropyridine;

5-fluoro-2-({6-methyl-1-[2-(2-phenylethyl)benzoyl]piperidin-3-yl}methoxy)pyridine;

5-fluoro-2-({(3R,6R)-6-methyl-1-[2-(2-phenylethyl)benzoyl]piperidin-3-yl}methoxy)pyridine;

7-[(5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl)carbonyl]-1H-indole;

7-[((2R,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl)carbonyl]-1H-indole;

2-{2-[(5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl)carbonyl]phenyl}pyrimidine;

2-{2-[((2R,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl)carbonyl]phenyl}pyrimidine;

3-methyl-2-({6-methyl-1-[2-(3-methyl-1,2,4-oxadiazol-5-yl)benzoyl]piperidin-3-yl}methoxy)pyridine;

3-methyl-2-({(3R,6R)-6-methyl-1-[2-(3-methyl-1,2,4-oxadiazol-5-yl)benzoyl]piperidin-3-yl}methoxy)pyridine;

2-(2-{[2-methyl-5-({[6-(1,3-oxazol-2-yl)pyridin-2-yl]oxy}methyl)piperidin-1-yl]carbonyl}phenyl)pyrimidine;

2-(2-{[(2R,5R)-2-methyl-5-({[6-(1,3-oxazol-2-yl)pyridin-2-yl]oxy}methyl)piperidin-1-yl]carbonyl}phenyl)pyrimidine;

2-{2-[(5-{[(6-isopropylpyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl)carbonyl]phenyl}pyrimidine;

2-{2-[((2R,5R)-5-{[(6-isopropylpyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl)carbonyl]phenyl}pyrimidine;

4-{2-[(2-methyl-5-{[(3-methylpyridin-2-yl)oxy]methyl}piperidin-1-yl)carbonyl]phenyl}-1,3-thiazol-2-amine;

4-{2-[((2R,5R)-2-methyl-5-{[(3-methylpyridin-2-yl)oxy]methyl}piperidin-1-yl)carbonyl]phenyl}-1,3-thiazol-2-amine;

5-fluoro-2-({1-[2-fluoro-6-(2H-1,2,3-triazol-2-yl)benzoyl]-6-methylpiperidin-3-yl}methoxy)pyridine;

5-fluoro-2-({(3R,6R)-1-[2-fluoro-6-(2H-1,2,3-triazol-2-yl)benzoyl]-6-methylpiperidin-3-yl}methoxy)pyridine;

2-{3-fluoro-2-[(5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl)carbonyl]phenyl}pyrimidine;

2-{3-fluoro-2-[((2R,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl)carbonyl]phenyl}pyrimidine;

5-fluoro-2-({6-methyl-1-[2-(1H-1,2,4-triazol-5-yl)benzoyl]piperidin-3-yl}methoxy)pyridine;

5-fluoro-2-({(3R,6R)-6-methyl-1-[2-(1H-1,2,4-triazol-5-yl)benzoyl]piperidin-3-yl}methoxy)pyridine;

3-chloro-2-({6-methyl-1-[2-(2H-1,2,3-triazol-2-yl)benzoyl]piperidin-3-yl}methoxy)pyridine;

3-chloro-2-({(3R,6R)-6-methyl-1-[2-(2H-1,2,3-triazol-2-yl)benzoyl]piperidin-3-yl}methoxy)pyridine;

5-fluoro-2-({6-methyl-1-[2-(1H-pyrazol-1-yl)benzoyl]piperidin-3-yl}methoxy)pyridine;

5-fluoro-2-({(3R,6R)-6-methyl-1-[2-(1H-pyrazol-1-yl)benzoyl]piperidin-3-yl}methoxy)pyridine;

2-[(5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl)carbonyl]-3-phenylpyridine;

2-[((2R,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl)carbonyl]-3-phenylpyridine;

5-fluoro-2-({6-methyl-1-[(4-phenylpyridin-3-yl)carbonyl]piperidin-3-yl}methoxy)pyridine;

5-fluoro-2-({(3R,6R)-6-methyl-1-[(4-phenylpyridin-3-yl)carbonyl]piperidin-3-yl}methoxy)pyridine;

3-[(5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl)carbonyl]-2-phenylpyridine;

3-[((2R,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl)carbonyl]-2-phenylpyridine;

2-chloro-3-({6-methyl-1-[2-(2H-1,2,3-triazol-2-yl)benzoyl]piperidin-3-yl}methoxy)pyridine;

2-chloro-3-({(3R,6R)-6-methyl-1-[2-(2H-1,2,3-triazol-2-yl)benzoyl]piperidin-3-yl}methoxy)pyridine;

2-bromo-5-({6-methyl-1-[2-(2H-1,2,3-triazol-2-yl)benzoyl]piperidin-3-yl}methoxy)pyridine;

2-bromo-5-({(3R,6R)-6-methyl-1-[2-(2H-1,2,3-triazol-2-yl)benzoyl]piperidin-3-yl}methoxy)pyridine;

2-chloro-4-({6-methyl-1-[2-(2H-1,2,3-triazol-2-yl)benzoyl]piperidin-3-yl}methoxy)pyridine; and

2-chloro-4-({(3R,6R)-6-methyl-1-[2-(2H-1,2,3-triazol-2-yl)benzoyl]piperidin-3-yl}methoxy)pyridine;

or a pharmaceutically acceptable salt thereof.

12. A pharmaceutical composition which comprises an inert carrier and a compound of claim 1 or a pharmaceutically acceptable salt thereof.

13. A method for enhancing the quality of sleep in a mammalian patient in need thereof which comprises administering to the patient a therapeutically effective amount of the compound of claim 1 or a pharmaceutically acceptable salt thereof.

14. A method for treating insomnia in a mammalian patient in need thereof which comprises administering to the patient a therapeutically effective amount of the compound of claim 1 or a pharmaceutically acceptable salt thereof.

15. A method for treating or controlling obesity in a mammalian patient in need thereof which comprises administering to the patient a therapeutically effective amount of the compound of claim 1 or a pharmaceutically acceptable salt thereof.