IP Library › Patent Application 13569654
Patent Application
App. No. 13/569,654

Pharmaceutical Formulations Containing Lipoic Acid Derivatives

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Quick Facts
Patent No.
US None
App. No.
13/569,654
Abstract

Pharmaceutical formulations containing lipoic acid derivatives and ion pairs thereof are described. The pharmaceutical formulations are useful in the treatment of medical disorders, such as cancer.

Claims (26)

1 - 52 . (canceled)

53 . A method of treating a cancer of the pancreas or ovary in a patient, comprising administering to a patient in need thereof a pharmaceutical formulation comprising:

(a) at least one compound having the structure represented by Formula I:

(b) at least one ion pairing agent that is either:

(i) a tertiary amine, diethanolamine, monoethanolamine, mefenamic acid, tromethamine, polyethyleneimine, or a combination thereof or

(ii) lysine, diethylamine, piperazine, or ethylenediamine; and

(c) a pharmaceutically acceptable diluent;

wherein the compound of Formula I and the ion pairing agent form an ion pair.

54 . The method of claim 53 , wherein the at least one ion pairing agent is a tertiary amine.

55 . The method of claim 53 , wherein the at least one ion pairing agent is selected from the group consisting of triethanolamine, polyethyleneimine, diethanolamine, monoethanolamine, mefenamic acid, tromethamine, and combinations thereof.

56 . The method of claim 53 , wherein the at least one ion pairing agent is triethanolamine.

57 . The method of claim 53 , wherein the at least one ion pairing agent and the at least one compound of Formula I is present in a ratio ranging from 20:1 to 1:20.

58 . The method of claim 56 , wherein the at least one ion pairing agent and the at least one compound of Formula I is present in a ratio ranging from 20:1 to 1:20.

59 . The method of claim 53 , wherein the at least one ion pairing agent and the at least one compound of Formula I is present in a ratio ranging from 10:1 to 1:10.

60 . The method of claim 56 , wherein the at least one ion pairing agent and the at least one compound of Formula I is present in a ratio ranging from 10:1 to 1:10.

61 . The method of claim 56 , wherein the at least one ion pairing agent and the at least one compound of Formula I is present in a ratio of about 8:1.

62 . The method of claim 53 , wherein the ion pair is present in the pharmaceutical formulation in an amount to provide from about 0.001 mg/m 2 to about 10 g/m 2 of the compound of Formula I upon administration of the pharmaceutical formulation to the patient.

63 . The method of claim 53 , wherein the diluent is selected from the group consisting of saline, a sugar solution, an alcohol, dimethylformamide, dimethylsulfoxide, dimethylacetamide, and combinations thereof.

64 . The method of claim 53 , wherein the diluent is a dextrose solution.

65 . The method of claim 64 , wherein the dextrose solution contains an amount of dextrose ranging from 2.5% to 10% by weight.

66 . The method of claim 53 , wherein the cancer is a cancer of the pancreas.

67 . The method of claim 56 , wherein the cancer is a cancer of the pancreas.

68 . The method of claim 61 , wherein the cancer is a cancer of the pancreas.

69 . The method of claim 53 , wherein the cancer is a cancer of the ovary.

70 . The method of claim 56 , wherein the cancer is a cancer of the ovary.

71 . The method of claim 61 , wherein the cancer is a cancer of the ovary.