Secondary structure stabilized NMDA receptor modulators and uses thereof
Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of diseases and disorders such as learning, cognitive activities, and analgesia, particularly in alleviating and/or reducing neuropathic pain.
1. A compound represented by:
wherein
R 4 is H;
R 1 is benzyl;
R 5 is
R 6 is
R 2 is H or CH 3 ,
R 3 is H or CH 3 , and stereoisomers, N-oxides or pharmaceutically acceptable salts thereof.
2. A pharmaceutically acceptable composition comprising a compound of claim 1 , and a pharmaceutically acceptable excipient.
3. The compound of claim 1 , wherein R 2 and R 3 are CH 3 .
4. The compound of claim 1 , wherein R 2 is CH 3 and R 3 is H.
5. The compound of claim 1 , represented by:
6. A compound represented by: