Positive allosteric modulators of mGluR2

1. A compound according to Formula I

wherein:

X is selected from the group consisting of C and N;

Y is C 1-6 alkyl;

R 1 is selected from the group consisting of:

(1) C 2-8 alkyl,

(2) C 2-8 alkenyl,

(3) C 2-8 alkynyl,

(4) C 3-6 cycloalkyl-(CH 2 ) p —, wherein p is 1, 2, 3 or 4, and

(5) benzyl,

wherein groups (1) to (5) above are optionally substituted with 1 to 3 R 2 groups;

each R 2 is independently selected from the group consisting of: halo, OH, C 1-4 alkyl, C 1-4 alkoxy, CF 3 , —OCF 3 and —CN;

ring A is selected from the group consisting of phenyl and pyridyl, wherein said phenyl and pyridyl are optionally substituted with one or more R 3 groups up to the maximum number of substitutable positions;

each R 3 is independently selected from the group consisting of:

(1) halo,

(2) C 1-8 alkyl,

(3) C 2-6 alkenyl,

(4) C 2-6 alkynyl,

(5) C 3-6 cycloalkyl,

(6) C 1-6 alkoxy,

(7) C 3-6 cycloalkoxy,

(8) —CN,

(9) —OH,

(10) —C(O)—O—C 1-4 alkyl,

(11) —C(O)—C 1-4 alkyl,

(12) —N(R) 2 ,

(13) —C(O)—N(R) 2 ,

(14) —S(O) k —C 1-4 alkyl, wherein k is 0, 1 or 2,

(15) -aryl,

(16) -heteroaryl,

(17) -heterocycle,

(18) —C(O)-aryl,

(19) —N(R)-aryl,

(20) benzyl,

(21) benzyloxy,

(22) aryl-O—,

(23) heteroaryl-O—,

(24) heterocycle-O—

(23) —CO 2 H,

(24) —SH,

(25) —SO 2 N(R)R,

(26) —N(R)C(O)N(R)R,

(27) —N(R)C(O)C 1-4 alkyl,

(28) —N(R)SO 2 N(R)R,

(29) —B(OH) 2 ,

(30) heteroaryl-CH 2 —,

(31) heterocycle-CH 2 —,

(32) aryl-C(O)—N(R)—CH 2 —,

(33) heteroaryl-C(O)—N(R)—CH 2 —,

(34) heteroaryl-CH 2 —C(O)—N(R)—CH 2 —,

(35) heterocycle-CH 2 —C(O)—N(R)—CH 2 —, and

(36) C 1-6 alkyl-C(O)—N(R)—CH 2 —,

wherein groups (2) to (7), (10), (11), (14) to (24), (27) and (30) to (36) above are optionally substituted from one up to the maximum number of substitutable positions with one or more substituents independently selected from the group consisting of: OH, CN, halo, —N(R) 2 , —C(O)—N(R) 2 , —CH 2 —N(R) 2 , —C(O)—CH 2 —N(R) 2 , carboxy, —C(O)—O—C 1-4 alkyl, —C(O)—C(R) 2 —C(O)—O—C 1-4 alkyl, —CH 2 —C 3-6 cycloalkyl, C 1-4 alkoxy, C 1-4 alkylamino, acetyl, acetylamino, methylsulfonyl, methylsulfonylamino, phenyl, heterocycle, heteroaryl, heteroaryl-C(O)—, C 1-4 alkyl and C 1-4 alkyl-C(O)—, said C 1-4 alkyl, C 1-4 alkyl-C(O)—, heteroaryl and heteroaryl-C(O)-optionally substituted with 1 to 3 halogen atoms and hydroxyl, and heteroaryl and heteroaryl-C(O)— additionally optionally substituted with methyl, and each R is independently selected from the group consisting of: H and C 1-4 alkyl;

aryl at each occurrence is independently selected from the group consisting of: phenyl, naphthyl, anthryl and phenanthryl;

heteroaryl at each occurrence independently means a 5- or 6-membered monocyclic aromatic or 9- or 10-membered bicyclic aromatic, wherein at least one atom in the aromatic is selected from the group consisting of N(R), O and S, the sulfur optionally oxidized to sulfone or sulfoxide, and the remaining atoms are selected from the group consisting of C, N(R), O and S, the sulfur optionally oxidized to sulfone or sulfoxide;

heterocycle at each occurrence independently means a 5- or 6-membered monocyclic non-aromatic ring or 9- or 10-membered bi- or spiro-cyclic fully or partially unsaturated ring, wherein each said ring is optionally substituted with 1 to 2 oxo groups, wherein at least one atom of said 5- or 6-membered monocyclic non-aromatic ring or said 9- or 10-membered bi-or spiro-cyclic fully or partially unsaturated ring is selected from the group consisting of N(R), O and S, the sulfur optionally oxidized to sulfone or sulfoxide, and the remaining atoms are selected from the group consisting of C, N(R), O and S, the sulfur optionally oxidized to sulfone or sulfoxide;

or a pharmaceutically acceptable salt thereof.

2. A compound according to claim 1 wherein each R 3 is independently selected from the group consisting of:

(1) halo,

(2) C 1-8 alkyl,

(3) C 2-6 alkenyl,

(4) C 2-6 alkynyl,

(5) C 3-6 cycloalkyl,

(6) C 1-6 alkoxy,

(7) C 3-6 cycloalkoxy,

(8) —CN,

(9) —OH,

(10) —C(O)—O—C 1-4 alkyl,

(11) —C(O)-C 1-4 alkyl,

(12) —N(R) 2 ,

(13) —C(O)—N(R) 2 ,

(14) —S(O)k-C 1-4 alkyl, wherein k is 0, 1 or 2,

(15) -aryl,

(16) -hetero aryl,

(17) -heterocycle,

(18) —C(O)-aryl,

(19) —N(R)-aryl,

(20) benzyl,

(21) benzyloxy,

(22) aryl-O—,

(23) heteroaryl-O—,

(24) heterocycle-O—

(23) —CO 2 H,

(24) —SH,

(25) —SO 2 N(R)R,

(26) —N(R)C(O)N(R)R,

(27) —N(R)C(O)C 1-4 alkyl,

(28) —N(R)SO 2 N(R)R,

(29) —B(OH) 2 ,

(30) heteroaryl-CH 2 —,

(31) heterocycle-CH 2 —,

(32) aryl-C(O)—N(R)—CH 2 —, and

(33) heteroaryl-C(O)—N(R)—CH 2 —,

wherein groups (2) to (7), (10), (11), (14) to (24), (27) and (30) to (33) above are optionally substituted from one up to the maximum number of substitutable positions with one or more substituents independently selected from the group consisting of: OH, CN, halo, —N(R) 2 , —C(O)—N(R) 2 , —CH 2 —N(R) 2 , carboxy, —C(O)—O—C 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkylamino, acetyl, acetylamino, methylsulfonyl, methylsulfonylamino, phenyl, heterocycle, heteroaryl, heteroaryl-C(O)—, C 1-4 alkyl and C 1-4 alkyl-C(O)—, said C 1-4 alkyl, C 1-4 alkyl-C(O)— and heteroaryl optionally substituted with 1 to 3 halogen atoms and hydroxy, and each R is independently selected from the group consisting of: H and C 1-4 alkyl.

3. The compound according to claim 2 wherein X is C.

4. The compound according to claim 2 wherein X is N.

5. The compound according to claim 2 wherein Y is methyl.

6. The compound according to claim 2 wherein R 1 is selected from the group consisting of: cyclopropylmethyl, 2,2-difluorocyclopropylmethyl, cyclobutylmethyl, 2,2-dimethylpropyl and benzyl, optionally substituted with methoxy or —OCF 3 .

7. The compound according to claim 2 of Formula Ia

or a pharmaceutically acceptable salt thereof.

8. The compound according to claim 7 wherein R 3 is selected from the group consisting of: (1) —CN, (2) halo, (3) —CF 3 , (4) 1,1-dioxidothiomorpholin-4-yl, (5) morpholin-4-ylmethyl, (6) —C(O)—O—C 1-4 alkyl, (7) C 1-6 alkoxy, (8) C 1-6 alkyl, optionally substituted with hydroxy, ( 9 ) piperazinyl, optionally substituted with —C(O)—O—C 1-4 alkyl or isoxazolylcarbonyl, and (10) piperidinyl, optionally substituted with —C(O)—O—C 1-4 alkyl or isoxazolylcarbonyl.

9. The compound according to claim 2 of Formula Ib

or a pharmaceutically acceptable salt thereof.

10. The compound according to claim 9 wherein R 3 is selected from the group consisting of: (1) —CN, (2) halo, (3) —CF 3 , (4) 1,1-dioxidothiomorpholin-4-yl, (5) morpholin-4-ylmethyl, (6) —C(O)—O—C 1-4 alkyl, (7) C 1-6 alkoxy, (8) C 1-6 alkyl, optionally substituted with hydroxy, (9) piperazinyl, optionally substituted with —C(O)—O—C 1-4 alkyl or isoxazolylcarbonyl, and (10) piperidinyl, optionally substituted with —C(O)—O—C 1-4 alkyl or isoxazolylcarbonyl.

11. The compound according to claim 2 of Formula Ic

or a pharmaceutically acceptable salt thereof, wherein

ring B is heteroaryl,

R 3 is CN, halo or C 1-4 alkyl, optionally substituted with 1-5 halo atoms, and

each R 4 is independently selected from the group consisting of: —CN, halo, —N(R) 2 , C 1-4 alkoxy, —C(O)—O—C 1-4 alkyl, and C 1-4 alkyl, optionally substituted with hydroxy.

12. The compound according to claim 2 of Formula Id

or a pharmaceutically acceptable salt thereof, wherein

ring C is heterocycle,

R 3 is CN, halo or C 1-4 alkyl, optionally substituted with 1-5 halo atoms, and

each RS is independently selected from the group consisting of: OH, acetyl, methylsulfonyl, acetylamino, —C(O)—O—C 1-4 alkyl and C 1-4 alkyl, optionally substituted with 1-3 halo atoms or hydroxy.

13. The compound according to claim 2 of Formula Ie

or a pharmaceutically acceptable salt thereof, wherein

R 3 is CN, halo or C 1-4 alkyl, optionally substituted with 1-5 halo atoms, and

R 6 is independently selected from the group consisting of: pyrimidinyl, pyridyl, methylsulfonyl, acetyl, 2-hydroxypropanoyl and 2-hydroxyethanoyl.

14. The compound according to claim 2 of Formula If

or a pharmaceutically acceptable salt thereof, wherein

R 3 is CN, halo or C 1-4 alkyl, optionally substituted with 1-5 halo atoms, and

R 7 is selected from the group consisting of: pyrimidinyl, pyridyl, methylsulfonyl, acetyl, 2-hydroxypropanoyl and 2-hydroxyethanoyl.

15. The compound according to claim 2 of Formula Ig

or a pharmaceutically acceptable salt thereof, wherein

n is 0 or 1,

R 3 is CN, halo or C 1-4 alkyl, optionally substituted with 1-5 halo atoms, and

R 8 is selected from the group consisting of: acetylamino, methylsulfonyl, methylsulfonylamino, pyrimidinyl, pyridyl, 2-oxo-l-pyrrolidinyl, —C(O)—N(R) 2 and C 1-4 alkyl, said C 1-4 alkyl optionally substituted with 1-3 halo atoms or hydroxy, and said pyridyl optionally substituted with fluoro.

16. The compound according to claim 2 of Formula Ih

or a pharmaceutically acceptable salt thereof, wherein

R 3 is CN, halo or C 1-4 alkyl, optionally substituted with 1-5 halo atoms, and

R 9 is pyridyl and R 10 is hydroxy or R 9 and R 10 and joined together with the atom to which they are attached to form 5-oxo-imidazolidine, oxetane or azetidine, said azetidine optionally substituted with —C(O)—O—C 1-4 alkyl.

17. The compound according to claim 2 of Formula Ij

or a pharmaceutically acceptable salt thereof, wherein

ring D is heteroaryl,

R 3 is CN, halo or C 1-4 alkyl, optionally substituted with 1-5 halo atoms, and

each R 11 is independently selected from the group consisting of: —CN, halo, —N(R) 2 , C 1-4 alkoxy, —C(O)—O—C 1-4 alkyl, and C 1-4 alkyl, optionally substituted with hydroxy.

18. A compound of Formula lk

or a pharmaceutically acceptable salt thereof, wherein

X is selected from the group consisting of C and N;

R 1 is selected from the group consisting of:

(1) C 2-8 alkyl,

(2) C 2-8 alkenyl,

(3) C 2-8 alkynyl,

(4) C 3-6 cycloalkyl-(CH 2 ) p —, wherein p is 1, 2, 3 or 4, and

(5) benzyl,

wherein groups (1) to (5) above are optionally substituted with 1 to 3 R 2 groups;

each R 2 is independently selected from the group consisting of: halo, OH, C 1-4 alkyl, C 1-4 alkoxy, CF 3 , —OCF 3 and —CN;

ring E is heteroaryl,

R 3 is CN, halo or C 1-4 alkyl, optionally substituted with 1-5 halo atoms, and

each R 12 is independently selected from the group consisting of: —CN, halo, —N(R) 2 , C 1-4 alkoxy, —C(O)—O—C 1-4 alkyl, and C 1-4 alkyl, optionally substituted with hydroxy.

19. A compound according to claim 2 wherein said compound is:

2-[1-(cyclopropylmethyl)-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl]benzonitrile;

2-[1-(cyclopropylmethyl)-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl]-6-fluorobenzonitrile;

1-(cyclopropylmethyl)-3-methyl-5-(2-methylphenyl)-1,3-dihydro-2,1,3-benzothiadiazole2,2-dioxide;

1-(cyclopropylmethyl)-5-(2-ethylphenyl)-3-methyl-1,3-dihydro-2,1,3-benzothiadiazole2,2-dioxide;

2-[1-(cyclopropylmethyl)-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl]-5-fluorobenzonitrile;

4-[1-(cyclopropylmethyl)-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl]benzonitrile;

1-(cyclopropylmethyl)-3-methyl-5-phenyl-1,3-dihydro-2,1,3-benzothiadiazole2,2-dioxide;

1-(cyclopropylmethyl)-5-(2-fluorophenyl)-3-methyl-1,3-dihydro-2,1,3-benzothiadiazole2,2-dioxide;

3-[1-(cyclopropylmethyl)-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl]benzonitrile;

2-[1-(cyclopropylmethyl)-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl]-3-fluorobenzonitrile;

2-[1-(cyclopropylmethyl)-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl]-3,6-difluorobenzonitrile;

1-(cyclopropylmethyl)-3-methyl-5-[2-(trifluoromethyl)phenyl]-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide;

3-[1-(cyclopropylmethyl)-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl]-4-fluorobenzonitrile;

3-[1-(cyclopropylmethyl)-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl]-2-fluorobenzonitrile;

1-(cyclopropylmethyl)-[3-methyl-5-3-(trifluoromethyl)phenyl]-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide;

1-(cyclopropylmethyl)-5-[4-(1,1-dioxidothiomorpholin-4-yl)phenyl]-3-methyl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide;

1-(cyclopropylmethyl)-5-[3-(1,1-dioxidothiomorpholin-4-yl)phenyl]-3-methyl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide;

2-[1-(cyclopropylmethyl)-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl]pyridine-3-carbonitrile;

4-[1-(cyclopropylmethyl)-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl]pyridine-3-carbonitrile;

4-[1-(cyclopropylmethyl)-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl]pyridine-2-carbonitrile;

1-(cyclopropylmethyl)-3-methyl-5-(4-methylpyridin-3-yl)-1,3-dihydro-2,1,3-benzothiadiazole2,2-dioxide;

3-[1-(cyclopropylmethyl)-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl]pyridine-2-carbonitrile;

5-[1-(cyclopropylmethyl)-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5--yl]pyridine-2-carbonitrile;

1-(cyclopropylmethyl)-5-(2-fluoropyridin-3-yl)-3-methyl-1,3-dihydro-2,1,3-benzothiadiazole2,2-dioxide;

1-(cyclopropylmethyl)-3-methyl-5-(5-methylpyridin-3-yl)-1,3-dihydro-2,1,3-benzothiadiazole2,2-dioxide;

3-[1-(cyclopropylmethyl)-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl]pyridine-4-carbonitrile;

1-(cyclopropylmethyl)-3-methyl-5-[3-(morpholin-4-ylmethyl)phenyl]-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide;

2-[1-(cyclopropylmethyl)-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl]-4-(morpholin-4-ylmethyl)benzonitrile;

2-{2-[1-(cyclopropylmethyl)-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl]phenyl}propan-2-ol;

2-{3-[1-(cyclopropylmethyl)-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl]phenyl}propan-2-ol;

2-{4-[1-(cyclopropylmethyl)-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl]phenyl}propan-2-ol;

1-(cyclopropylmethyl)-3-methyl-5-(3-methylpyridin-2-yl)-1,3-dihydro-2,1,3-benzothiadiazole2,2-dioxide;

2-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}benzonitrile;

2-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}-4-(hydroxymethyl)benzonitrile;

ethyl 3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}-2-fluorobenzoate;

1-[(2,2-difluorocyclopropyl)methyl]-5-[3-(1,1-dioxidothiomorpholin-4-yl)phenyl]-3-methyl-1,3-dihydro-2,1,3-benzothiadiazole2,2-dioxide;

2-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}-4-methoxybenzonitrile;

2-[1-(2,2-dimethylpropyl)-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl]benzonitrile;

2-[1-(3-hydroxypropyl)-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl]benzonitrile;

2-[1-(cyclobutylmethyl)-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl]benzonitrile;

1-(cyclobutylmethyl) -5-[3-(1,1-dioxidothiomorpholin-4-yl)phenyl]-3-methyl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide;

2-[1-(4-methoxybenzyl)-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl]benzonitrile;

2-{3-methyl-2,2-dioxido-1-[4-(trifluoromethoxy)benzyl]-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}benzonitrile;

5-[3-(1,1-dioxidothiomorpholin-4-yl)phenyl]-3-methyl-1-[4-(trifluoromethoxy)benzyl]-1,3-dihydro-2,1,3-benzothiadiazole2,2-dioxide;

6-(4-cyano-3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}phenoxy)pyridine-2-carbonitrile;

4-(4-cyano-3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}phenoxy)pyridine-2-carbonitrile;

4-[(3-chloropyrazin-2-yl)oxy]-2-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}benzonitrile;

2-(4-cyano-3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}phenoxy)-1,3-thiazole-4-carbonitrile;

2-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}-4-(pyrazin-2-yloxy)benzonitrile;

2-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}-4-{[6-(hydroxymethyl)pyrazin-2-yl]oxy}benzonitrile;

2-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}-4-[(6-methylpyrazin-2-yl)oxy]benzonitrile;

2-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}-4-[(3-methylpyrazin-2-yl)oxy]benzonitrile;

methyl 2-(4-cyano-3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}phenoxy)pyrimidine-5-carboxylate;

4-[(2-chloropyrimidin-4-yl)oxy]-2-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}benzonitrile;

4-amino-2-(4-cyano-3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}phenoxy)pyrimidine-5-carbonitrile;

methyl 5-(4-cyano-3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}phenoxy)pyrazine-2-carboxylate;

3-(4-cyano-3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}phenoxy)pyrazine-2-carbonitrile;

6-(4-cyano-3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}phenoxy)pyrazine-2-carbonitrile;

2-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}-4-{[4-(methylamino)pyrimidin-2-yl]oxy}benzonitrile;

2-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}-4-[(2-methoxypyrimidin-4-yl)oxy]benzonitrile;

2-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}-4-{[2-(methylamino)pyrimidin-4-yl]oxy}benzonitrile;

4-{4-cyano-3-[1-(2,2-dimethylpropyl)-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl]phenoxy}pyridine-2-carbonitrile;

4-{4-cyano-3-[1-(cyclopropylmethyl)-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl]phenoxy}pyridine-2-carbonitrile;

4-(4-cyano-3-{3-methyl-2,2-dioxido-1-[4-(trifluoromethoxy)benzyl]-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}phenoxy)pyridine-2-carbonitrile;

4-(cyanomethoxy)-2-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}benzonitrile;

2-(3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}-4-methylphenyl)propan-2-ol;

2-(3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}-4-methylphenyl)propan-2-ol;

2-(3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}-2-fluorophenyl)propan-2-ol;

2-{3-[1-(cyclopropylmethyl)-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl]-4-methylphenyl}propan-2-ol;

2-{3-[1-(2,2-dimethylpropyl)-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl]-4-methylphenyl}propan-2-ol;

2-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}-4-[(3-hydroxy-6,7-dihydroisoxazolo[4,5-c]pyridin-5(4H)-yl)methyl]benzonitrile;

4-[(4-acetylpiperazin-1-yl)methyl]-2-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}benzonitrile;

2-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}-4-{[4-(methylsulfonyl)piperazin-1-yl]methyl}benzonitrile;

2-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}-4-[(1,1-dioxidothiomorpholin-4-yl)methyl]benzonitrile;

5-{5-[(4-acetylpiperazin-1-yl)methyl]-2-fluorophenyl}-1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-1,3-dihydro-2,1,3-benzothiadiazole2,2-dioxide;

1-[(2,2-difluorocyclopropyl)methyl]-5-(2-fluoro-5-{[4-(methylsulfonyl)piperazin-1-yl]methyl}phenyl)-3-methyl-1,3-dihydro-2,1,3-benzothiadiazole2,2-dioxide;

1-[(2,2-difluorocyclopropyl)methyl]-5-(2-fluoro-5-{[4-(2,2,2-trifluoroethyl)piperazin-1-yl]methyl}phenyl)-3-methyl-1,3-dihydro-2,1,3-benzothiadiazole2,2-dioxide;

5-{3-[(4-acetylpiperazin-1-yl)methyl]-2-fluorophenyl}-1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-1,3-dihydro-2,1,3-benzothiadiazole2,2-dioxide;

1-[(2,2-difluorocyclopropyl)methyl]-5-(2-fluoro-3-{[4-(methylsulfonyl)piperazin-1-yl]methyl}phenyl)-3-methyl-1,3-dihydro-2,1,3-benzothiadiazole2,2-dioxide;

1-[(2,2-difluorocyclopropyl)methyl]-5-(2-fluoro-3-{[4-(2,2,2-trifluoroethyl)piperazin-1-yl]methyl}phenyl)-3-methyl-1,3-dihydro-2,1,3-benzothiadiazole2,2-dioxide;

2-cyano-N-{3-[1-(cyclopropylmethyl)-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl]benzyl}benzamide;

2-{3-[1-(cyclopropylmethyl)-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl]benzyl}-1H-isoindole-1,3(2H)-dione;

N-{3-[1-(cyclopropylmethyl)-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl]benzyl}benzamide;

3-cyano-N-{3-[1-(cyclopropylmethyl)-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl]benzyl}benzamide;

N-{3-[1-(cyclopropylmethyl)-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl]benzyl}isoxazole-3-carboxamide;

2-({3-[1-(cyclopropylmethyl)-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl]benzyl}amino)nicotinonitrile;

4-({3-[1-(cyclopropylmethyl)-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl]benzyl}amino)pyridine-2-carbonitrile;

1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-5-(6-{[4-(methylsulfonyl)piperazin-1-yl]methyl}pyridin-2-yl)-1,3-dihydro-2,1,3-benzothiadiazole2,2-dioxide;

5-{6-[(4-acetylpiperazin-1-yl)methyl]pyridin-2-yl}-1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-1,3-dihydro-2,1,3-benzothiadiazole2,2-dioxide;

5-{6-[(4-acetylpiperazin-1-yl)methyl]pyridin-3-yl}-1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-1,3-dihydro-2,1,3-benzothiadiazole2,2-dioxide;

1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-5-(6-{[4-(methylsulfonyl)piperazin-1-yl]methyl}pyridin-3-yl)-1,3-dihydro-2,1,3-benzothiadiazole2,2-dioxide;

5-{5-[(4-acetylpiperazin-1-yl)methyl]pyridin-3-yl}-1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-1,3-dihydro-2,1,3-benzothiadiazole2,2-dioxide;

1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-5-(5-{[4-(methylsulfonyl)piperazin-1-yl]methyl}pyridin-3-yl)-1,3-dihydro-2,1,3-benzothiadiazole2,2-dioxide;

5-{2-[(4-acetylpiperazin-1-yl)methyl]pyridin-4-yl}-1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-1,3-dihydro-2,1,3-benzothiadiazole2,2-dioxide;

1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-5-(2-{[4-(methylsulfonyl)piperazin-1-yl]methyl}pyridin-4-yl)-1,3-dihydro-2,1,3-benzothiadiazole2,2-dioxide;

5-{4-[(4-acetylpiperazin-1-yl)methyl]pyridin-2-yl}-1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-1,3-dihydro-2,1,3-benzothiadiazole2,2-dioxide;

1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-5-(3-methyl-6-{[4-(methylsulfonyl)piperazin-1-yl]methyl}pyridin-2-yl)-1,3-dihydro-2,1,3-benzothiadiazole2,2-dioxide;

1-{4-[(6-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}-5-methylpyridin-2-yl)methyl]piperazin-1-yl}ethanone;

2-(6-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}-5-methylpyridin-2-yl)propan-2-ol;

2-[1-(cyclopropylmethyl)-3-methyl-2,2-dioxido-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridin-5-yl]benzonitrile;

1-(cyclopropylmethyl)-5-[3-(1,1-dioxidothiomorpholin-4-yl)phenyl]-3-methyl-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridine 2,2-dioxide;

2-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridin-5-yl}benzonitrile;

1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-5-(2-methylphenyl)-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridine 2,2-dioxide;

1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-5-[2-(trifluoromethyl)phenyl]-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridine 2,2-dioxide;

1-[(2,2-difluorocyclopropyl)methyl]-5-[3-(1,1-dioxidothiomorpholin-4-yl)phenyl]-3-methyl-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridine 2,2-dioxide;

tert-butyl 4-(4-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridin-5-yl}phenyl)piperazine-1-carboxylate;

tert-butyl 4-(3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridin-5-yl}phenyl)piperazine-1-carboxylate;

(3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridin-5-yl}phenyl)methanol;

(3-{1-[(2,2-difluoro cyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridin-5-yl}-4-fluorophenyl)methanol;

(3-{1-[(2,2-difluoro cyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridin-5-yl}-2-fluorophenyl)methanol;

2-[1-(2,2-dimethylpropyl)-3-methyl-2,2-dioxido-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridin-5-yl]benzonitrile;

1-(2,2-dimethylpropyl)-5-[3-(1,1-dioxidothiomorpholin-4-yl)phenyl]-3-methyl-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridine 2,2-dioxide;

1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-5-{3-[1-(methylsulfonyl)piperidin-4-yl]phenyl}-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridine 2,2-dioxide;

1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-5-{4-[4-(methylsulfonyl)piperazin-1-yl]phenyl}-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridine 2,2-dioxide;

1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-5-{3-[4-(methylsulfonyl)piperazin-1-yl]phenyl}-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridine 2,2-dioxide;

1-[(2,2-difluorocyclopropyl)methyl]-5-{4-[4-(isoxazol-3-ylcarbonyl)piperazin-1-yl]phenyl}-3-methyl-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridine 2,2-dioxide;

1-[4-(3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro[1,2,5]thiadiazolo [3,4-b]pyridin-5-yl}phenyl)piperazin-1-yl]ethanone;

4-(4-cyano-3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridin-5-yl}phenoxy)pyridine-2-carbonitrile;

4-{4-cyano-3-[1-(cyclopropylmethyl)-3-methyl-2,2-dioxido-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridin-5-yl]phenoxy}pyridine-2-carbonitrile;

4-{4-cyano-3-[1-(2,2-dimethylpropyl)-3-methyl-2,2-dioxido-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridin-5-yl]phenoxy}pyridine-2-carbonitrile;

2-(3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridin-5-yl}-2-fluorophenyl)propan-2-ol;

2-(3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3dihydro[1,2,5]thiadiazolo[3,4-b]pyridin-5-yl}-4-methylphenyl) propan-2-ol;

2-{3-[1-(cyclopropyl methyl)-3-methyl-2,2-dioxido-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridin-5-y1]-4-methyl phenyl}propan-2-ol;

2-{3-[1-(2,2-dimethyl propyl)-3-methyl-2,2-dioxido-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridin-5-y1]-4-methyl phenyl}propan-2-ol;

1-[4-(3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro[1,2,5]thiadiazolo [3,4-b]pyridin-5-yl}-4-methylb enzyl)piperazin-1-yl]ethanone;

1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-5-(2-methyl-5-{[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]methyl}phenyl)-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridine 2,2-dioxide;

1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-5-(2-methyl-5-{[4-(methylsulfonyl)piperazin-1-yl]methyl}phenyl)-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridine 2,2-dioxide;

1-[(2,2-difluorocyclopropyl)methyl]-5-{5-[(1,1-dioxidothiomorpholin-4-yl)methyl]-2-methylphenyl}-3-methyl-1,3-dihydro[1,2,5 ]thiadiazolo[3,4-b]pyridine 2,2-dioxide;

1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-5-(2-methyl-5-{[4-(methylsulfonyl)piperidin-1-yl]methyl}phenyl)-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridine 2,2-dioxide;

1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-5-(2-methyl-5-{[4-(methylsulfonyl)piperazin-1-yl]methyl}phenyl)-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridine 2,2-dioxide;

N-[1-(3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridin-5-yl}-4-methylbenzyl)piperidin-4-yl]acetamide;

tert-butyl (3aR,6aS)-5-(3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridin-5-yl}-4-methylbenzyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate;

1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-5-(2-methyl-5-{[4-(pyrimidin-2-yl)piperazin-1-yl]methyl}phenyl)-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridine 2,2-dioxide;

1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-5-(2-methyl-5-{[4-(pyridin-2-yl)piperazin-1-yl]methyl}phenyl)-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridine 2,2-dioxide;

1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-5-(2-methyl-5-{[4-(pyrazin-2-yl)piperazin-1-yl]methyl}phenyl)-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridine 2,2-dioxide;

1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-5-(2-methyl-5-{[4-(pyridin-4-yl)piperazin-1-yl]methyl}phenyl)-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridine 2,2-dioxide;

1-(3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridin-5-yl}-4-methylbenzyl)piperidine-4-carboxamide;

1-(3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridin-5-yl}-4-methylb enzyl)-N-methylpiperidine-4-carbox amide;

2-[1-(3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridin-5-yl}-4-methylbenzyl)piperidin-4-yl]propan-2-ol;

1-(3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridin-5-yl}-4-methylbenzyl)-4-(pyridin-3-yl)piperidin-4-ol;

1-(3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridin-5-yl}-4-methylbenzyl)-4-(pyridin-2-yl)piperidin-4-ol;

N-[1-(3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridin-5-yl}-4-methylbenzyl)piperidin-4-yl]methanesulfonamide;

tert-butyl 7-(3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridin-5-yl}-4-methylbenzyl)-2,7-diazaspiro[3.5 ]nonane-2carboxylate;

tert-butyl 7-(3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridin-5-yl}-4-methylb enzyl)-1 ,7-diazaspiro[3.5 ]nonane-1-carboxylate;

1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-5-(2-methyl-5-{[4-(pyrimidin-2-yl)pip eridin-1-yl]methyl}phenyl)-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridine 2,2-dioxide;

8-(3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridin-5-yl}-4-methylbenzyl)-1,3,8-triazaspiro[4.5]decan-4-one 1-[(2,2-difluorocyclopropyl)methyl]-5-(5-{[4-(6-fluoropyridin-2-yl)piperidin-1-yl]methyl}-2-methylphenyl)-3-methyl-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridine 2,2-dioxide;

1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-5 42-methyl-5-(2-oxa-7-azaspiro[3.5 ]non-7-ylmethyl)phenyl]-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridine 2,2-dioxide;

1-[1-(3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridin-5-yl}-4-methylbenzyl)piperidin-4-yl]pyrrolidin-2-one;

1-(3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridin-5-yl}-4-methylbenzyl)-4-[(dimethylamino)methyl]piperidin-4-ol;

[1-(3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridin-5-yl}-4-methylbenzyl)piperidin-4-yl]methanol;

[3-(3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridin-5-yl}-4-methylbenzyl)-3-azabicyclo[3.1.0]hex-6-yl]methanol;

1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-5-(2-methyl-5-{[4-(pyridin-4-yl)piperidin-1-yl]methyl}phenyl)-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridine 2,2-dioxide;

1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-5-(2-methyl-5-{[4-(pyridin-2-yl)piperidin-1-yl]methyl}phenyl)-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridine 2,2-dioxide;

1-(3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridin-5-yl}-4-methylbenzyl)piperidine-3-carboxamide;

[1-(3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridin-5-yl}-4-methylbenzyl)piperidin-3-yl]methanol;

7-(3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridin-5-yl}-4-methylbenzyl)-2,7-diazaspiro[4.5]decan-1-one;

1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-5-(2-methyl-5-{[3-(methylsulfonyl)pyrrolidin-1-yl]methyl}phenyl)-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridine 2,2-dioxide;

[1-(3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridin-5-yl}-4-methylbenzyl)pyrrolidin-3-yl]methanol;

1-[4-(3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridin-5-yl}benzyl)piperazin-1-yl]ethanone;

1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-5-(3-{[4-(methylsulfonyl)piperazin-1-yl]methyl}phenyl)-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridine 2,2-dioxide;

1-[4-(3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridin-5-yl}-4-fluorobenzyl)piperazin-1-yl]ethanone;

1-[(2,2-difluorocyclopropyl)methyl]-5-(2-fluoro-5-{[4-(methylsulfonyl)piperazin-1-yl]methyl}phenyl)-3-methyl-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridine 2,2-dioxide;

1-[4-(3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro[1,2,5 9 thiadiazolo[3,4-b]pyridin-5-yl}-2-fluorobenzyl)piperazin-1-yl]ethanone;

1-[(2,2-difluorocyclopropyl)methyl]-5-(2-fluoro-3-{[4-(methylsulfonyl)piperazin-1-yl]methyl}phenyl)-3-methyl-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridine 2,2-dioxide;

1-[(2,2-difluorocyclopropyl)methyl]-5-{3-[(1,1-dioxidothiomorpholin-4-yl)methyl]-2-fluorophenyl}-3-methyl-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridine 2,2-dioxide;

1-[(2,2-difluorocyclopropyl)methyl]-5-(2-fluoro-3-{[4-(methylsulfonyl)piperidin-1-yl]methyl}phenyl)-3-methyl-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridine 2,2-dioxide;

(2R)-1-[4-(3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridin-5-yl}-4-methylbenzyl)piperazin-1-yl]-2-hydroxyprop an-1-one;

(2S)-1-[4-(3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridin-5-yl}-4-methylbenzyl)piperazin-1-yl]-2-hydroxypropan-1-one; or 1-[4-(3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridin-5-yl}-4-methylbenzyl)piperazin-1-yl]-2-hydroxyethanone;

or a pharmaceutically acceptable salt thereof.

20. A compound according to claim 1 wherein said compound is

N-{3-[1-(cyclopropylmethyl)-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl]benzyl}benzamide;

1-(3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridin-5-yl}-4-methylbenzyl)-3-methylimidazolidine-2,4-dione;

N-(3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridin-5-yl}-4-methylbenzyl)-2-(1H-1,2,4-triazol-1-yl)acetamide;

(2R)-1-[4-(4-chloro-3-{1-(2R)-N-(3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridin-5-yl}-4-methylbenzyl)-2-hydroxypropanamide;

1-[4-(4-chloro-3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridin-5-yl}benzyl)piperazin-1-yl]ethanone;

(2R)-1-[4-(4-chloro-3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridin-5-yl}benzyl)piperazin-1-yl]-2-hydroxyprop an-1-one;

2-[4-(6-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}-5-methylpyridin-2-yl)piperazin-1-yl]-2-oxoethanol;

3-cyano-6-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}-2-[4-(isoxazol-3-ylcarbonyl)piperazin-1-yl]pyridinium chloride;

3-cyano-2-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}-6-[4-(isoxazol-3-ylcarbonyl)piperazin-1-yl]pyridinium chloride;

tert-butyl 4-(5-cyano-6-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}pyridin-2-yl)piperazine-1-carboxylate;

tert-butyl 4-(3-cyano-6-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}pyridin-2-yl)piperazine-1-carboxylate;

2-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}-6-(1,1-dioxidothiomorpholin-4-yl)-3-methylpyridinium chloride;

6-{4-[(acetyloxy)acetyl]piperazin-1-yl}-2-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}-3-methylpyridinium trifluoroacetate;

4-(5-cyano-6-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}pyridin-2-yl)piperazin-1-ium chloride;

6-chloro-2-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}nicotinonitrile;

2-chloro-6-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}nicotinonitrile;

(2R)-1-[4-(6-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}-5-methylpyridin-2-yl)piperazin-1-yl]-1-oxopropan-2-ol;

(2S)-1-[4-(6-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}-5-methylpyridin-2-yl)piperazin-1-yl]-1-oxopropan-2-ol;

2-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}-6-[4-(methylsulfonyl)piperazin-1-yl]nicotinonitrile;

1-(6-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}-5-methylpyridin-2-yl)piperidin-4-one;

8-(6-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}-5-methylpyridin-2-yl)-1,4-dioxa-8-azaspiro[4.5 ]decane;

8-(6-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}-3-methylpyridin-2-yl)-1,4-dioxa-8-azaspiro[4.5 ]decane;

2-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}-3-methyl-6-morpholin-4-ylpyridinium chloride;

6-{4-[2-(acetyloxy)-2-methylpropanoyl]piperazin-1-yl}-2-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}-3-methylpyridinium trifluoroacetate;

2-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}-6-{4-[(dimethylammonio)acetyl]piperazin-1-yl}-3-methylpyridinium dichloride;

1-[4-(6-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}-5-methylpyridin-2-yl)piperazin-1-yl]-2-methyl-1-oxopropan-2-ol;

1-(6-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}-5-methylpyridin-2-yl)piperidin-4-ol;

4-(6-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}-5-methylpyridin-2-yl)-1-(2,2,2-trifluoroethyl)piperazin-1-ium chloride;

2-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}-6-(4-methoxypiperidin-1-yl)-3-methylpyridinium chloride;

1-(cyclopropylmethyl)-4-(6-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}-5-methylpyridinium-2-yl)piperazin-1-ium dichloride;

2-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}-3-methyl-644-(methylsulfonyl)piperazin-1-yl]pyridinium chloride;

2-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}-3-methyl-6-{4-[(1-methyl-1H-imidazol-3-ium-2-yl)carbonyl]piperazin-1-yl}pyridinium dichloride;

2-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}-6-[4-(isoxazol-3-ylcarbonyl)piperazin-1-yl]-3-methylpyridinium chloride; or 1-[(2,2-difluorocyclopropyl)methyl]-5-(6-fluoro-3-methylpyridin-2-yl)-3-methyl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide;

or a pharmaceutically acceptable salt thereof.

21. The compound according to claim 1 wherein R 1 is 2,2-difluorocyclopropylmethyl.

22. A compound according to claim 1 of Formula Il

or pharmaceutically acceptable salts thereof, wherein:

one of the R 3 groups shown in Formula Il is selected from the group consisting of H, CN and methyl; the other R 3 group is H;

R 13 is selected from the group consisting of: —C(O)—CH 2 —N(R) 2 , —C(O)—O—C 1-4 alkyl, —C(O)-C(R) 2 —C(O)—O—C 1-4 alkyl, —CH 2 —C 3-6 cycloalkyl, C 1-4 alkoxy, methylsulfonyl, heteroaryl -C(O)—, C 1-4 alkyl and C 1-4 alkyl-C(O)—, said C 1-4 alkyl, C 1-4 alkyl-C(O)— and heteroaryl-C(O)— optionally substituted with 1 to 3 halogen atoms and hydroxy and heteroaryl-C(O)-additionally optionally substituted with methyl, and each R is independently selected from the group consisting of: H and C 1-4 alkyl.

23. A pharmaceutical composition comprising a compound according to claim 1 in combination with a pharmaceutically acceptable carrier.

24. A method for treating schizophrenia in a patient in need thereof comprising administering to the patient a therapeutically effective amount of a compound according to claim 1 .

25. A method for treating schizophrenia in a patient in need thereof comprising administering to the patient a therapeutically effective amount of a compound according to claim 19 .

26. A method for treating schizophrenia in a patient in need thereof comprising administering to the patient a therapeutically effective amount of a compound according to claim 20 .