IP Library Granted Patent US 8,790,599
Granted Patent B2
US 8,790,599 · App. 13/584,414 · Granted Jul 29, 2014

Microtiter plate system and method

Inventors: David Childs (Lansdale, PA); Michael Sharer (Schwenksville, PA)
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Quick Facts
Patent No.
US 8,790,599
App. No.
13/584,414
Granted
Jul 29, 2014
Kind
B2
Abstract

A system for analyzing, manipulating, and recording data associated with a microtiter plate is provided. The system provides a touch screen element provided proximal to the microtiter plate such that data pertaining to events and conditions observed within one or more wells of the microtiter plate may be easily and accurately recorded. Data display, storage, and manipulation features are also provided.

Claims (43)

1. A system for use in connection with a microtiter plate, the system comprising:

a microtiter plate comprising a plurality of wells;

a cover portion positioned proximal to a top surface of the microtiter plate, the cover portion comprising a substantially transparent planar touch screen and an array of predetermined regions, the predetermined regions corresponding to at least one of the number and positioning of the wells;

each of the predetermined regions comprising a capacitive sensing point configured to generate an indicia upon contact by a user;

the cover portion operatively associated with a central processing unit, the central processing unit configured to perform at least one of: receiving, storing, transmitting, displaying, and processing data received from the cover portion; and

wherein the cover portion is provided on a vertical support member, the vertical support member comprising a rotatable base member, and at least one vertical support for supporting the weight of the cover member and the microtiter plate.

2. The system of claim 1 , wherein the indicia is a binary indicia.

3. The system of claim 1 , wherein the cover portion comprises a housing with an internal storage volume, the internal storage volume adapted to receive the microtiter plate.

4. The system of claim 1 , wherein the cover portion and the microtiter plate are selectively positionable between a first position and a second position, the first and second positions being offset by approximately ninety degrees of rotation.

5. The system of claim 1 , wherein the cover portion comprises a plurality of substantially opaque lines intersecting at perpendicular angles, the plurality of substantially opaque lines comprising a grid delineating the array of predetermined regions.

6. The system of claim 1 , wherein the vertical support member comprises a display unit, the display unit provided for at least one of displaying, storing, and manipulating data.

7. A system for use in connection with a microtiter plate comprising a plurality of wells, the system comprising:

a microtiter plate comprising a plurality of wells;

a cover portion selectively securable proximal a first surface of the microtiter plate, the cover portion comprising a substantially transparent planar touch screen and an array of predetermined regions corresponding to the plurality of wells of the microtiter plate;

each of the predetermined regions comprising capacitive sensing points configured to generate an indicia upon contact by a user;

a central processing unit in operative communication with the cover portion and operative to perform at least one of: receiving, storing, transmitting, displaying, and processing data received from the cover portion; and

a support structure for supporting the cover portion and the microtiter plate, the support structure comprising at least one rotational member for rotating and selectively securing the cover portion and the microtiter between a first position and a second position, the second position characterized by approximately ninety degrees of rotation about a longitudinal axis of the cover portion from the first position.

8. The system of claim 7 , wherein the indicia is a binary indicia.

9. The system of claim 7 , wherein the cover portion comprises a housing with an internal storage volume, the internal storage volume adapted to receive the microtiter plate.

10. The system of claim 7 , wherein the cover portion and the microtiter plate are selectively positionable between a first position and a second position, the first and second positions being offset by approximately ninety degrees of rotation.

11. The system of claim 7 , wherein the cover portion comprises a plurality of substantially opaque lines intersecting at perpendicular angles, the plurality of substantially opaque lines comprising a grid delineating the array of predetermined regions.

12. The system of claim 7 , wherein the cover portion is provided on a vertical support member, the vertical support member comprising a rotatable base member, and at least one vertical support for supporting the weight of the cover member and the microtiter plate.

13. The system of claim 7 , wherein the vertical support member comprises a display unit, the display unit provided for at least one displaying, storing, and manipulating data.

14. A method of analyzing the contents of a microtiter plate, the method comprising:

positioning a microtiter plate comprising a plurality of wells proximal to a cover portion comprising a substantially transparent planar touch screen and an array of predetermined regions, the predetermined regions corresponding to at least one of the number and positioning of the wells, each of the predetermined regions comprising capacitive sensing points configured to generate an indicia upon contact by a user, and the cover portion operatively associated with a central processing unit, such that each of the predetermined regions correspond to a single well;

analyzing the contents of at least one well of the microtiter plate;

based on said analyzing step, selectively activating at least one capacitive sensing point corresponding to the at least one well based on the presence or absence of a predetermined condition within the at least one well;

transmitting information related to the selective activation of the at least one capacitive sensing point to a central processing unit; and

the central processing unit performing at least one of the steps selected from the group consisting of: storing, transmitting, displaying, and processing data related to the at least one capacitive sensing point.

15. The method of claim 14 , wherein the indicia is a binary indicia.

16. The method of claim 14 , wherein the cover portion comprises a housing with an internal storage volume, the internal storage volume adapted to receive the microtiter plate.

17. The method of claim 14 , wherein the cover portion and the microtiter plate are selectively positionable between a first position and a second position, the first and second positions being offset by approximately ninety degrees of rotation.

18. The method of claim 14 , wherein the cover portion comprises a plurality of substantially opaque lines intersecting at perpendicular angles, the plurality of substantially opaque lines comprising a grid delineating the array of predetermined regions.

19. The method of claim 14 , wherein the cover portion is provided on a vertical support member, the vertical support member comprising a rotatable base member, and at least one vertical support for supporting the weight of the cover member and the microtiter plate.

20. The method of claim 14 , wherein the vertical support member comprises a display unit, the display unit provided for at least one displaying, storing, and manipulating data.

21. A method of analyzing the contents of a microtiter plate, the method comprising:

conducting at least one assay in at least one well of a microtiter plate, the microtiter plate comprising a plurality of wells;

positioning the microtiter plate proximal to a cover portion comprising a substantially transparent planar touch screen and an array of predetermined regions, the predetermined regions corresponding to at least one of the number and positioning of the wells, each of the predetermined regions comprising capacitive sensing points configured to generate an indicia upon contact by a user, and the cover portion operatively associated with a central processing unit, such that each of the predetermined regions correspond to a single well;

rotating the microtiter plate and the cover portion to a substantially vertical position after a predetermined amount of time; and

selectively activating at least one capacitive sensing point corresponding to a first well based on the results of the at least one assay.

22. The method of claim 21 , further comprising: transmitting information related to the selective activation of the at least one capacitive sensing point to a central processing unit.

23. The method of claim 22 , wherein the central processing unit performs at least one of the steps selected from the group consisting of: storing, transmitting, displaying, and processing data related to the at least one capacitive sensing point.

24. The method of claim 22 , wherein the predetermined amount of time comprises approximately two minutes or less.

Assignments (7)
RELEASE OF SECURITY INTEREST Recorded Dec 8, 2021
From: JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT
To: PHARMACEUTICAL PRODUCT DEVELOPMENT, LLC
Reel/Frame 058334/0093 →
RELEASE OF SECURITY INTEREST Recorded Jan 15, 2021
From: CREDIT SUISSE AG, CAYMAN ISLANDS BRANCH, AS COLLATERAL AGENT
To: JAGUAR HOLDING COMPANY I; JAGUAR HOLDING COMPANY II; PHARMACEUTICAL PRODUCT DEVELOPMENT, LLC
Reel/Frame 054931/0201 →
SECURITY INTEREST Recorded Jan 13, 2021
From: PHARMACEUTICAL PRODUCT DEVELOPMENT, LLC
To: JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT
Reel/Frame 054902/0481 →
RELEASE OF SECURITY INTEREST Recorded Sep 2, 2015
From: CREDIT SUISSE AG, CAYMAN ISLANDS BRANCH, AS ADMINISTRATIVE AGENT
To: PHARMACEUTICAL PRODUCT DEVELOPMENT, LLC; PPD DEVELOPMENT, L.P.; PHARMACO INVESTEMENTS, INC.; X-CHEM, INC.
Reel/Frame 036481/0051 →
SECURITY AGREEMENT Recorded Sep 2, 2015
From: PHARMACEUTICAL PRODUCT DEVELOPMENT, LLC; PPD DEVELOPMENT, L.P.; PHARMACO INVESTEMENTS, INC.; X-CHEM, INC.
To: CREDIT SUISSE AG, CAYMAN ISLANDS BRANCH, AS COLLATERAL AGENT
Reel/Frame 036528/0004 →
INTELLECTUAL PROPERTY SECURITY AGREEMENT SUPPLEMENT Recorded Jun 12, 2015
From: PHARMACO INVESTMENTS, INC.
To: CREDIT SUISSE AG, CAYMAN ISLANDS BRANCH, AS ADMINISTRATIVE AGENT
Reel/Frame 035900/0352 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 18, 2014
From: CHILDS, DAVID; SHARER, MICHAEL
To: PHARMACEUTICAL PRODUCT DEVELOPMENT, INC.
Reel/Frame 033766/0463 →
Continuity (1)
Related Publication 20140045168A1 · Feb 13, 2014