Anti-virus therapy for respiratory diseases
The present invention provides the use of IFN-β, an agent that increases the expression of IFN-β, or a polynucleotide which is capable of expressing IFN-β or said agent for the manufacture of a medicament for the treatment of rhinovirus-induced exacerbation of a respiratory disease selected from asthma and chronic obstructive pulmonary disease, wherein said treatment is by airway delivery of said medicament, e.g. by use of an aerosol nebuliser. Also provided is IFN-λ for the same purpose.
1. A method of treating a patient with a viral-induced exacerbation of a respiratory disorder, the method comprising: administering to the patient a therapeutically effective amount of an agent, wherein the agent comprises:
(a) an interferon-λ (IFN-λ) polypeptide or
(b) a polynucleotide which expresses an IFN-λ polypeptide in a target bronchial epithelial cell,
wherein the administration results in suppression of viral replication causing said viral-induced exacerbation in the patient, and said respiratory disorder is asthma or chronic obstructive pulmonary disease (COPD).
2. The method of claim 1 , wherein said respiratory disorder is asthma.
3. The method of claim 1 , wherein the viral-induced exacerbation is caused by infection with a virus selected from the group consisting of rhinovirus, RSV and influenza virus.
4. The method of claim 1 , wherein said agent comprises an IFNλ polypeptide selected from the group consisting of IFNλ1, IFNλ2 and IFNλ3.
5. The method of claim 1 , wherein said agent comprises a polynucleotide which expresses in a target bronchial epithelial cell an IFNλ polypeptide selected from the group consisting of IFNλ1, IFNλ2 and IFNλ3.
6. The method of claim 1 , wherein said agent is formulated for administration by airway delivery.
7. The method of claim 6 , wherein said agent is administered to the lung airways by means of an aerosol nebuliser.
8. The method of claim 1 , wherein the administration of said agent is to the lower respiratory tract.
9. The method of claim 1 , wherein said agent is administered simultaneously, separately or sequentially in combination with an additional therapeutic agent.
10. The method of claim 9 , wherein said additional therapeutic agent is an inhaled corticosteroid.