Therapeutic compounds for blocking DNA synthesis of pox viruses
View Patent ↗This invention provides methods of inhibiting replication of a poxvirus by contacting a poxvirus with a compound having formula I, formula XXI, formula XXXII, or formula XLI which in turn reduce, inhibit, or abrogate poxvirus DNA polymerase activity and/or its interaction with its processivity factor. Formula I, formula XXI, formula XXXII, or formula XLI can be utilized to treat humans and animals suffering from a poxvirus infection. Pharmaceutical compositions for treating poxvirus infected subjects are also provided.
1. A method of inhibiting, treating, or abrogating a poxvirus infection in a subject comprising the step of administering to said subject a compound having the formula XXII
2. The method of claim 1 , wherein said step of inhibiting replication of a poxvirus comprises inhibiting DNA synthesis.
3. The method of claim 1 , wherein said poxvirus is a vaccinia virus or a variola virus.
4. The method of claim 1 , wherein said DNA polymerase is an E9 DNA polymerase or a homologue thereof from a different species.
5. The method of claim 1 , whereby said compound reduces, inhibits, or abrogates interaction of said DNA polymerase with a processivity factor, thereby affecting activity of said DNA polymerase.
6. The method of claim 5 , wherein said processivity factor is an A20 or D4R processivity factor or a homologue thereof from a different species.