METHOD FOR TREATING BRAIN CANCER
Methods and compositions for treating brain cancer are disclose including refractory brain cancer.
1 . A method of treating brain cancer comprising administering to a patient in need of treatment a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof
wherein R 1 represents hydrogen, a halogen or a sulfono group SO 3 M, in which M is a metal ion, and R 2 represents hydrogen, or R 1 is Cl and R 2 is I.
2 . The method of claim 1 , said compound is tris(8-quinolinolato)gallium(III).
3 . The method of claim 2 , wherein said brain cancer is not glioblastoma.
4 . The method of claim 2 , wherein said brain cancer is astrocytoma.
5 . The method of claim 2 , wherein said brain cancer is glioblastoma.
6 . The method of claim 2 , wherein said brain cancer is a refractory brain cancer.
7 . The method of claim 2 , wherein said brain cancer was previously treated with BCNU.
8 . The method of claim 7 , further comprising administering to said patient a therapeutically effective amount of temozolomide.
9 . The method of claim 2 , wherein said brain cancer was previously treated with temozolomide.
10 . The method of claim 9 , further comprising administering to said patient a therapeutically effective amount of temozolomide.
11 . The method according to claims 2 , further comprising administering to said patient a therapeutically effective amount of temozolomide.
12 . A kit comprising:
an effective amount of a compound of Formula (I)
wherein R 1 represents hydrogen, a halogen or a sulfono group SO 3 M, in which M is a metal ion, and R 2 represents hydrogen, or R 1 is Cl and R 2 is I, or a pharmaceutically acceptable salt thereof; and
an effective amount of temozolomide.
13 . The kit of claim 12 , wherein said compound is tris(8-quinolinolato)gallium(III).
14 . A pharmaceutical composition comprising:
an effective amount of a compound of Formula (I)
wherein R 1 represents hydrogen, a halogen or a sulfono group SO 3 M, in which M is a metal ion, and R 2 represents hydrogen, or R 1 is Cl and R 2 is I, or a pharmaceutically acceptable salt thereof; and
an effective amount of temozolomide.
15 . The pharmaceutical composition of claim 14 , wherein said compound is tris(8-quinolinolato)gallium(III).