Topical itraconazole formulations and uses thereof
Methods of transdermally delivering a therapeutic amount of a triazole-triazolone compound are provided, e.g. for the prevention or treatment of basal cell carcinoma (BCC) in a subject. A therapeutic level of a triazole-triazolone compound such as itraconazole is delivered transdermally to a subject. Also provided are topical triazole-triazolone compositions that find use in practicing the subject methods.
1. A method for treating basal cell carcinoma (BCC) in a subject, the method comprising:
contacting a topical surface of the subject with a transdermal cream composition of an oil in water emulsion, comprising:
itraconazole at a concentration of from 1% to 12%
one or more hydrophobic oils selected from cetyl alcohol, labrasol and Vaseline, at a combined concentration of from 30% to 40%;
a cyclodextrin complexing agent at a concentration of from 5-10%;
an glycerol monooleate at a concentration of from 5-10%;
a caprylic triglyceride at a concentration of from 5-10%; and
a surfactant selected from a poloxamer and TWEEN 80 at a concentration of from 1-20%;
and delivering a therapeutic amount of itraconazole.