IP Library Granted Patent US 9,169,489
Granted Patent B2
US 9,169,489 · App. 13/608,702 · Granted Oct 27, 2015

Transgenic soybean plants expressing a soybean homolog of glycine-rich protein 7 (GRP7) and exhibiting improved innate immunity

Inventors: James R. Alfano (Lincoln, NE); Anna Joe (Lincoln, NE); Thomas E. Clemente (Lincoln, NE); Zhengqing Fu (Cary, NC); Ming Guo (Lincoln, NE); Byeong-Ryool Jeong (Omaha, NE); Thomas Elthon (Lincoln, NE)
Assignee: NUtech Ventures
C12N15/8279C07K14/415C12N15/8281
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Quick Facts
Patent No.
US 9,169,489
App. No.
13/608,702
Granted
Oct 27, 2015
Kind
B2
Abstract

This disclosure provides for transgenic soybean plants expressing a soybean homolog of glycine-rich protein 7 (GRP7) and exhibiting improved innate immunity and methods of making such plants.

Claims (17)

1. A method of increasing the innate immunity exhibited by a soybean plant comprising:

introducing a transgene into a plurality of soybean cells to produce transgenic soybean cells, wherein the transgene comprises a nucleic acid sequence having at least 99% sequence identity to the nucleotide sequence of SEQ ID NO: 33 encoding soybean glycine rich RNA binding protein as set forth in SEQ ID NO: 34, wherein the nucleic acid sequence is operably linked to a promoter functional in soybean cells;

regenerating transgenic soybean plants from the transgenic soybean cells;

identifying at least one of said transgenic soybean plants expressing said transgene encoding said soybean glycine rich RNA binding protein;

exposing at least one of said transgenic soybean plants expressing said transgene encoding said soybean glycine rich RNA binding protein to a biotic stress; and

identifying at least one of said transgenic soybean plants that exhibits increased innate immunity in response to the biotic stress relative to a control plant.

2. The method of claim 1 , wherein said transgene comprises the nucleic acid sequence of SEQ ID NO: 33.

3. The method of claim 1 , wherein said biotic stress is selected from the group consisting of a pathogen-induced stress and a wound-induced stress.

4. The method of claim 1 , wherein the promoter is a constitutive promoter.

5. A method of increasing the innate immunity exhibited by a soybean plant comprising:

introducing a transgene into a plurality of soybean cells to produce transgenic soybean cells, wherein the transgene comprises a nucleic acid sequence that encodes a polypeptide having the amino acid sequence of SEQ ID NO: 34, wherein the nucleic acid sequence is operably linked to a promoter functional in soybean cells;

regenerating transgenic soybean plants from the transgenic soybean cells;

identifying at least one of said transgenic soybean plants expressing said transgene encoding said polypeptide;

exposing at least one of said transgenic soybean plants expressing said transgene to a biotic stress; and

identifying, at least one of said transgenic soybean plants that exhibits increased innate immunity in response to the biotic stress relative to a control plant.

6. The method of claim 5 , wherein said biotic stress is selected from the group consisting of a pathogen-induced stress and a wound-induced stress.

7. The method of claim 5 , wherein the promoter is a constitutive promoter.

Assignments (4)
CONFIRMATORY LICENSE Recorded Sep 18, 2015
From: UNIVERSITY OF NEBRASKA-LINCOLN / NUTECH VENTURES
To: NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR
Reel/Frame 036598/0339 →
CONFIRMATORY LICENSE Recorded Jul 11, 2013
From: BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF NEBRASKA LINCOLN
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 030787/0246 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 17, 2013
From: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
To: NUTECH VENTURES
Reel/Frame 030433/0806 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 8, 2012
From: ALFANO, JAMES R.; JOE, ANNA; CLEMENTE, THOMAS E.; FU, ZHENGQING; GUO, MING; JEONG, BYEONG-RYOOL; ELTHON, THOMAS
To: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
Reel/Frame 029265/0158 →
Continuity (2)
Provisional Application 61532526 · Sep 8, 2011
Related Publication 20130074217A1 · Mar 21, 2013