CERIA FOR USE AS AN ANTIMICROBIAL BARRIER AND DISINFECTANT IN A WOUND DRESSING
The present invention relates to protecting a human from an infection using a disinfecting agent as described herein and a method for use thereof, more particularly to a rare earth-containing device for protecting a wound and a method for use thereof.
1 . A method, comprising:
contacting one or more rare earth-containing compositions with an infectious biological matter having a first infectious biological matter population, wherein the contacting of the one or more rare earth-containing compositions with the infectious biological matter forms a second infectious biological matter population, the second infectious biological matter population being less the first infectious biological matter population, wherein at least one of the one or more rare earth-containing compositions comprises particles or particulates having an average particle or particulate size from about 50 nanometers to about 1,000 microns and an average surface area of at least about 1 m 2 g −1 .
2 . The method of claim 1 , wherein the infectious biological matter comprises at least one of a bacterium, a protozoa, a virus, a fungi, a prion or a mixture thereof.
3 . The method of claim 1 , wherein the one or more rare earth-containing compositions further comprise a device, wherein the device comprises at least one of a textile, an item of apparel, a medical device, a therapeutic formulation, a cleaning composition, a cellulosic-containing material, a polymeric material, a coating material, an inorganic material, or a combination thereof.
4 . The method of claim 3 , wherein the device comprises one of a woven or non-woven textile, wherein the item of apparel is worn by animal, including a human, wherein the cleaning composition comprises a fluid or solid having at least one surfactant, wherein the cellulosic-containing material comprises at least one of a paper, a cotton, wood, a wood-containing product, or combination thereof product, and wherein the polymeric product comprises one of a homo-polymer, co-polymer, blockpolymer, polymeric mixture, polymeric alloy, or a combination thereof comprising at least one of a polyacetal, a polyacrylic, a polyanhydride, a polyamide, a polycarbonate, a polydiene, a polyester, a polyhalo-olefin, a polyimide, a polyimine, a polyketone, a polyolefin, a polyoxide, a polyphylene, a polyphosphazene, a polysilane, a polysiloxane, a polystyrene, a polysulfide, a polysulfoamide, a polysulfonate, a polysulfone, a polysulfoxide, a polythianhydride, a polythioamide, a polythiocarbonate, a polythioester, a polythioketone, a polythioimide, a polythiourea, a polythiourethane, a polyurea, a polyurethane, a polyvinyl, cellulose, chitin, keratin, and a combination or mixture thereof.
5 . The method of claim 3 , wherein the medical device comprises one of a suture, gauze, sponge, swab, dressing, drape, bandage, or a combination thereof.
6 . The method of claim 3 , wherein the medical device comprises one of a stapler, surgical instrument, a light-handle cover, medical tubing, medical mesh, an implant, drain component, wound vac component or combination thereof.
7 . The method of claim 3 , wherein the therapeutic formulation comprises one an aerosol spray, a powder, cream, ointment, slave, liniment, gel, medical solution, wound irrigation system, or combination thereof.
8 . The method of claim 1 , wherein the infectious biological matter is positioned on or adjacent to an organism, wherein the organism is one of an animal or a plant.
9 . The method of claim 8 , wherein the animal is one of a human, a domesticated animal, a wild animal, an animal raised as a source of food or income, a companion animal, or a combination thereof.
10 . The method of claim 9 , wherein the plant is one of a cultivate plant, an uncultivated or wild plant, a plant cultivated for nutritional purposes, plants cultivated for non-food purposes, and combinations thereof.
11 . The method of claim 1 , wherein the contacting of the one or more rare earth-containing compositions with the infectious matter further comprises:
killing and/or deactivating the infectious biological matter.
12 . The method of claim 11 , wherein the killing and/or deactivating further comprises:
an interaction of the infectious matter with the one or more rare earth-containing compositions, wherein the interaction comprises one of a chemical interaction, a physical interaction or a combination of a chemical and a physical interaction.
13 . The method of claim 13 , wherein the second infectious biological matter population divided by the first infectious biological matter population forms a quotient and wherein the quotient is less than about 1.
14 . The method of claim 13 , wherein the quotient is at most no more than about 10 −1 ′ at most no more than about 10 −2 , at most no more than about 10 −3 , at most no more than about 10 −4 , at most more than about 10 −5 , at most no more than about 10 −6 , at most no more than about 10 −7 , at most no more than about 10 −8 , at most no more than about 10 −9 , or at most no more than about 10 −10 .
15 . The method of claim 1 , wherein the average surface area is more than about 120 m 2 g −1 .
16 . The method of claim 1 , wherein the average particle size is from about 0.1 microns to about 10 microns.
17 . The method of claim 1 , wherein the average particle size is from about 1 micron to about 100 microns.
18 . The method of claim 1 , wherein one of the one or more rare earth-containing compositions comprises cerium.
19 . The method of claim 1 , wherein one of the one or more rare earth-containing compositions comprises cerium oxide.
20 . The method of claim 1 , wherein the one or more rare earth-containing composition comprises at least one of cerium (IV) oxide (CeO 2 ) and cerium (III) oxide (Ce 2 O 3 ).
21 . A method, comprising:
positioning one or more rare earth-containing compositions in a target zone, wherein the target zone has a first population of an infectious biological matter;
contacting the one or more rare earth-containing compositions with the infectious biological matter contained with the target zone; and
killing and/or deactivating the infectious biological matter to form a second population of the infectious biological matter, wherein the second population of the infectious biological matter is less than the first population of the infectious biological matter.
22 . The method of claim 21 , wherein the infectious biological matter comprises at least one of a bacterium, a protozoa, a virus, a fungi, a prion or a mixture thereof.
23 . The method of claim 21 , wherein the second infectious biological matter population divided by the first infectious biological matter population forms a quotient of less than about 1.
24 . The method of claim 23 , wherein the quotient is at most no more than about 10 −1 , at most no more than about 10 −2 , at most no more than about 10 −3 , at most no more than about 10 −4 , at most no more than about 10 −5 , at most no more than about 10 −6 , at most no more than about 10 −7 , at most no more than about 10 −8 , at most no more than about 10 −9 , or at most no more than about 10 −10 .
25 . The method of claim 21 , wherein one or more of the rare earth-containing compositions comprise a soluble rare earth-containing composition.
26 . The method of claim 25 , wherein the water soluble composition has a total dissolved rare earth concentration of at least about 1 M, of at least about 1×10 −1 M, of at least about 5×10 −2 M, of at least about 1×10 −2 M, or at least about of at least about 1×10 −3 M.
27 . The method of claim 21 , wherein one or more of the rare earth-containing compositions comprise a water insoluble rare earth-containing composition.
28 . The method of claim 27 , wherein the water insoluble rare earth-containing composition has a total dissolved rare earth concentration of less than about 5×10 −2 M, of less than about 1×10 −2 M, of less than about 1×10 −3 M, of less than about 1×10 −4 M, of less than about 1×10 −5 M, of less than about 1×10 −6 M, of less than about 1×10 −7 M, of less than about 1×10 −8 M, of less than about 1×10 −9 M, or of less than about 1×10 −10 M.
29 . The method of claim 21 , wherein the target zone is on or about one of an animal or plant.
30 . The method of claim 29 , wherein the target zone is one of a wound, an infected wound, a surgical area, an area prone to infection, an area to be protected from the infectious biological matter, an area infected and/or diseased with the infectious biological matter, or a combination thereof.
31 . The method of claim 29 , wherein the animal comprises a human.
32 . The method of claim 29 , wherein the animal comprises a domesticated animal, a wild animal, an animal raised as a source of food or income, a companion animal, or a combination thereof.
33 . The method of claim 29 , wherein the plant is one of a cultivate plant, an uncultivated or wild plant, a plant cultivated for nutritional purposes, plants cultivated for non-food purposes, and combinations thereof.
34 . The method of claim 21 , wherein the more or more rare earth-containing compositions comprise particles.
35 . The method of claim 34 , wherein the particles have an average particle size from about 0.1 nanometers to about 1,000 microns.
36 . The method of claim 34 , wherein the particles have an average surface area of at least about 1 m 2 g −1 .
37 . The method of claim 34 , wherein the particles have an average surface area of at least about 120 m 2 g −1 .
38 . The method of claim 21 , wherein cerium comprises at least one of the one or more rare earth-containing compositions.
39 . The method of claim 38 , wherein the other of the one or more rare earth-containing compositions comprise at least one rare earth element selected from the group of rare elements consisting of La, Nd, Pr, and Sm.
40 . The method of claim 21 , wherein one of the one or more rare earth-containing compositions comprises cerium oxide.
41 . The method of claim 21 , wherein the one or more rare earth-containing composition comprises at least one of cerium (IV) oxide (CeO 2 ) and cerium (III) oxide (Ce 2 O 3 ).
42 . An article, comprising:
one or more rare earth-containing compositions; and
one of:
i) a woven textile;
ii) a non-woven textile;
iii) an item of apparel;
iv) a medical device comprising a textile;
v) a medical device comprising a polymer;
vi) a medical device having a polymeric component;
vii) a medical implant;
viii) a therapeutic formulation;
ix) a cleaning composition;
x) a cellulosic-containing material;
xi) a polymeric material;
x) a coating material; and
xi) an inorganic material.
43 . The article of claim 42 , wherein one or more of the rare earth-containing compositions comprises a soluble rare earth-containing composition.
44 . The method of claim 43 , wherein the water soluble composition has a total dissolved rare earth concentration of at least about 1 M, of at least about 1×10 −1 M, of at least about 5×10 −2 M, of at least about 1×10 −2 M, or at least about of at least about 1×10 −3 M.
45 . The method of claim 42 , wherein one or more of the rare earth-containing compositions comprises a soluble rare earth-containing composition.
46 . The method of claim 45 , wherein the water insoluble composition has a total dissolved rare earth concentration of less than about 5×10 −2 M, of less than about 1×10 −2 M, of less than about 1×10 − M, of less than about 1×10 −4 M, of less than about 1×10 −5 M, of less than about 1×10 −6 M, of less than about 1×10 −7 M, of less than about 1×10 −8 M, of less than about 1×10 −9 M, or of less than about 1×10 −10 M.
47 . The method of claim 42 , wherein the more or more rare earth-containing compositions comprises particles.
48 . The method of claim 47 , wherein the particles have an average particle size from about 0.1 nanometers to about 1,000 microns.
49 . The method of claim 47 , wherein the particles have an average surface area of at least about 1 m 2 g −1 .
50 . The method of claim 47 , wherein the particles have an average surface area of at least about 120 m 2 g −1 .
51 . The method of claim 42 , wherein cerium comprises at least one of the one or more rare earth-containing compositions.
52 . The method of claim 51 , wherein the other of the one or more rare earth-containing compositions comprise at least one rare earth element selected from the group of rare elements consisting of La, Nd, Pr, and Sm.
53 . The method of claim 42 , wherein one of the one or more rare earth-containing compositions comprises cerium oxide.
54 . The method of claim 42 , wherein the one or more rare earth-containing composition comprises at least one of cerium (IV) oxide (CeO 2 ) and cerium (III) oxide (Ce 2 O 3 ).
55 - 64 . (canceled)