Pharmaceutical composition of salicylanilide-derived small molecules and preparation and application thereof

1. A salicylanilide-derived small molecule, as shown in formula II:

wherein R of formula II is selected from the group consisting of H and OCH 3 ; R′ of formula II is a Halogen, wherein the Halogen is F, Cl, Br, I or At.

2. A pharmaceutical composition of salicylanilide-derived small molecule, which comprises:

(a) a compound as shown in formula II:

(b) a pharmaceutical acceptable salt and carrier of the said compounds,

wherein R of formula II is selected from the group consisting of H and OCH 3 ; R′ of the formula II is a Halogen, wherein the Halogen is F, Cl, Br, I or At.

3. The pharmaceutical composition of claim 2 , wherein the pharmaceutical acceptable carrier is an excipient, diluent, thickener, filler, binder, disintegrant, lubricant, oil or non-oil base, surfactant, suspending agent, gelling agent, adjuvant, anti-corrosive agent, anti-oxidant, stabilizer, coloring agent or flavoring agent.

4. The pharmaceutical composition of claim 2 , wherein the salt is physiological acceptable salt of inorganic acid, inorganic base, organic acid or organic base.

5. The pharmaceutical composition of claim 2 , wherein said composition is a powder, granule, liquid, gel or cream.

6. The pharmaceutical composition of claim 2 , wherein said composition is administrated through oral, transdermal, injection, or inhalational manner.

7. A synthesis method of salicylanilide-derived small molecule, wherein a compound of formula II is synthesized by a compound of formula I:

wherein R of the formula I or formula II is selected from the group consisting of H and OCH 3 ; R′ of the formula I or formula II is a Halogen, wherein the Halogen is F, Cl, Br, I or At; and R″ of the formula I is H,

the method comprising:

adding methyl chloroformate to a solution of a compound of formula I and anhydrous pyridine and refluxing the mixture to obtain a compound of formula II.