Nucleic acid and amino acid sequences relating to
The invention provides methods of treating subject with polypeptides having at least 80% identity to SEQ ID NO: 5326. The methods stimulate an immune response in the subject and provide methods for prevention and treatment of pathological conditions resulting from bacterial infection.
1. A method of treating a subject, comprising the step of administering a composition that includes a polypeptide having at least 80% identity to the amino acid sequence of SEQ ID NO: 5326.
2. The method of claim 1 , wherein the polypeptide elicits an immune response when administered to the subject.
3. The method of claim 2 , wherein the immune response is an immune response against S. pneumonia.
4. The method of claim 1 , wherein the polypeptide provides a immune response against S. pneumonia infection that results in disease when administered to the subject.
5. The method of claim 1 , wherein the composition includes a pharmaceutically acceptable carrier.
6. The method of claim 5 , wherein the composition further includes an adjuvant.
7. The method of claim 6 , wherein the adjuvant is at least one member selected from the group consisting of aluminum hydroxide, N-acetyl-muramyl-L-threonyl-D-isoglutamine, N-acetyl-nor-muramyl-L-alanyl-D-isoglutamine, N-acetylmuramyl-L-alanyl-D-isoglutaminyl-L-alanine-2-(1′-2′-dipalmitoyl-sn-glycero-3-hydroxyphos-phoryloxy)-ethylamine; cholera toxin, a non-toxic derivative of cholera toxin, procholeragenoid, fungal polysaccharides, muramyl dipeptide, muramyl dipeptide derivatives, phorbol esters, labile toxin of E. coli , non- S. pneumoniae bacterial lysates, block polymers and saponins.
8. The method of claim 1 , wherein the isolated polypeptide has at least 90% identity to SEQ ID NO: 5326.
9. The method of claim 1 , wherein the isolated polypeptide has at least 95% identity to SEQ ID NO: 5326.
10. The method of claim 1 , wherein the isolated polypeptide has at least 98% identity to SEQ ID NO: 5326.
11. The method of claim 1 , wherein the isolated polypeptide has at least 99% identity to SEQ ID NO: 5326.