Optical coherence tomography lumen morphology and vascular resistance measurements methods for blood vessel evaluations
A method and apparatus of automatically locating in an image of a blood vessel the lumen boundary at a position in the vessel and from that measuring the diameter of the vessel. From the diameter of the vessel and estimated blood flow rate, a number of clinically significant physiological parameters are then determined and various user displays of interest generated. One use of these images and parameters is to aid the clinician in the placement of a stent. The system, in one embodiment, uses these measurements to allow the clinician to simulate the placement of a stent and to determine the effect of the placement. In addition, from these patient parameters various patient treatments are then performed.
1. An automated computer-based method of evaluating a blood vessel, the method comprising the steps of:
storing intravascular measurements in an electronic memory device, the intravascular measurements comprising distance measurements;
generating a set of data from intravascular measurements obtained regarding a segment of length L within the blood vessel using an optical coherence tomography system, the set of data comprising a plurality of cross sectional areas at a plurality of positions along the length L;
determining a vascular resistance ratio (VRR) with a resistor-based model or a model based on relative flow resistance using a processor and at least a portion of the set of data;
calculating a fractional flow reserve (FFR) from the VRR;
determining a characteristic of at least a portion of the segment disposed along the length L in response to the VRR or FFR; and
displaying the FFR or VRR.
2. The method of claim 1 wherein the characteristic is a stenotic lesion.
3. The method of claim 2 further comprising a step of displaying at least one of a numerical or graphical measure of a stent length and stent diameter used to treat the stenotic lesion.
4. The method of claim 1 further comprising steps of:
calculating a fractional flow reserve (FFR) value from the VRR; and
determining if the value of the FFR is indicates if treatment of the blood vessel is required.
5. The method of claim 1 further comprising a step of displaying the fractional flow reserve value on a display in electrical communication with the optical coherence tomography system.
6. The method of claim 1 wherein the intravascular measurements are scan lines obtained using an optical coherence tomography intravascular imaging probe.