Treatment of ischemic episodes and cerebroprotection through misoprostol
View Patent ↗The present invention provides compositions and methods for treating an ischemic episode using misoprostol alone or in combination with anti-thrombotic agents.
1. A method of treating an ischemic episode in a subject, the method comprising administering to said subject a composition comprising misoprostol and a pharmaceutically acceptable carrier, said composition administered in doses effective to achieve reduction in infarct volume of said subject's brain tissue.
2. A method of treating an ischemic episode in a subject, the method comprising administering to said subject within 24 hours after the onset of said ischemic episode the composition according to claim 1 , furthermore comprising an anti-thrombotic agent, said composition administered in doses effective to achieve reduction in infarct volume of said subject's brain tissue.
3. A method of treating an ischemic episode in a subject, the method comprising administering to said subject within 24 hours after the onset of said ischemic episode the composition according to claim 2 , wherein the anti-thrombotic agent is tissue plasminogen activator, said composition administered in doses effective to achieve reduction in infarct volume of said subject's brain tissue.
4. The method according to claim 1 , wherein the ischemic episode is caused by a stroke.
5. The method according to claim 2 , wherein the ischemic episode is caused by a stroke.
6. The method according to claim 3 , wherein the ischemic episode is caused by a stroke.
7. The method according to claim 1 , wherein the ischemic episode is caused by cardiac arrest.
8. The method according to claim 2 , wherein the ischemic episode is caused by cardiac arrest.
9. The method according to claim 3 , wherein the ischemic episode is caused by cardiac arrest.