Neuronal protection by cerium oxide nanoparticles
A method of treating a subject with elevated levels of peroxynitrite includes administering a therapeutically effective amount of cerium oxide nanoparticles to the subject, wherein the cerium oxide nanoparticles reduce the level of peroxynitrite in the subject.
1. A method of treating a subject with elevated levels of peroxynitrite, comprising:
administering a therapeutically effective amount of cerium oxide nanoparticles to the subject, wherein the cerium oxide nanoparticles reduce the level of peroxynitrite in the subject;
wherein the cerium oxide nanoparticles comprise more Ce 3+ than Ce 4+ .
2. The method of claim 1 , wherein the cerium oxide nanoparticles range between 1-5 nanometers in size.
3. The method of claim 1 , wherein the cerium oxide nanoparticles range between 5-10 nanometers in size.
4. The method of claim 1 , wherein said cerium oxide nanoparticles scavenge peroxynitrite.
5. A method of reducing brain inflammation in a patient, comprising:
administering a therapeutically effective amount of cerium oxide
nanoparticles to the patient, said cerium oxide nanoparticles effective to reduce peroxynitrite levels in the brain;
wherein the cerium oxide nanoparticles comprise more Ce 3+ than Ce 4+ .
6. The method of claim 5 wherein the cerium oxide nanoparticles comprise a higher 3+/4+ratio.